Mitochondrial dysfunction in skin biopsies and blood mononuclear cells from two cases of fibromyalgia patients.

abstract：OBJECTIVES:There has been growing interest in the use of serum B-type natriuretic peptide (BNP) and the N-terminal segment of its pro-hormone (NT-proBNP) as biomarkers for cardiac disease. The aim of this review is to summarize the current state of knowledge regarding BNP and NT-proBNP measurement in the pediatric popu...

journal_title：Clinical biochemistry

authors： Davis GK,Bamforth F,Sarpal A,Dicke F,Rabi Y,Lyon ME

更新日期：2006-06-01 00:00:00

abstract：OBJECTIVE:To evaluate relationships between apolipoprotein B (Apo B), LDL cholesterol (LDL-C), and non-HDL-C in high-risk patients treated with lipid-lowering therapy. DESIGN AND METHODS:This post-hoc analysis calculated LDL-C and non-HDL-C levels corresponding to an Apo B of 0.9 g/L following treatment with 1) statin...

journal_title：Clinical biochemistry

authors： Vaverkova H,Farnier M,Averna M,Missault L,Viigimaa M,Dong Q,Shah A,Johnson-Levonas AO,Brudi P

更新日期：2011-06-01 00:00:00

abstract：OBJECTIVE:The relationship between the severity of atherosclerotic coronary artery disease (CAD) and circulating levels of salusin-α, salusin-β and heregulin-β1 has been investigated. In addition, the relationship with these peptides and high sensitive C-reactive protein (hsCRP) has been investigated. METHODS:The stud...

journal_title：Clinical biochemistry

authors： Arkan A,Atukeren P,Ikitimur B,Simsek G,Koksal S,Gelisgen R,Ongen Z,Uzun H

更新日期：2021-01-01 00:00:00

abstract：:Point of Care Testing (POCT) refers to clinical laboratory testing performed outside the central laboratory, nearer to the patient and sometimes at the patient bedside. The testing is usually performed by clinical staff, such as physicians or nurses, who are not laboratory trained. This document was developed by the P...

journal_title：Clinical biochemistry

authors： Venner AA,Beach LA,Shea JL,Knauer MJ,Huang Y,Fung AWS,Dalton J,Provencal M,Shaw JLV

更新日期：2021-02-01 00:00:00

abstract：:The influence of age and disease on serum albumin and alpha-1-acid glycoprotein was studied in 126 subjects (69 M, 57 F) presenting with tuberculosis and after recovery. Albumin concentration fell with age in both disease and healthy states, and alpha-1-acid glycoprotein concentration rose with age in the healthy stat...

journal_title：Clinical biochemistry

authors： Woo J,Chan HS,Or KH,Arumanayagam M

更新日期：1994-08-01 00:00:00

abstract：:Matrix metalloproteinases (MMPs) may play a pathophysiological role in the development of diabetic nephropathy (DN). We hypothesized that urinary MMP activity in patients with type 2 diabetes mellitus (T2DM) is related to a decline in renal function. We determined MMP-2, -8 and -9 activity in 24-h urine collections in...

journal_title：Clinical biochemistry

authors： van der Zijl NJ,Hanemaaijer R,Tushuizen ME,Schindhelm RK,Boerop J,Rustemeijer C,Bilo HJ,Verheijen JH,Diamant M

更新日期：2010-05-01 00:00:00

abstract：:Fluoride is a potent therapeutic agent that increases spinal bone density in osteoporotic subjects. Based on work with animal cells previously, we proposed fluoride acts by inhibiting phosphotyrosyl protein phosphatase (EC 3.1.3.48) activity in bone cells. The presence of fluoride sensitive acid phosphatase (EC 3.1.3....

journal_title：Clinical biochemistry

authors： Wergedal JE,Lau KH

更新日期：1992-02-01 00:00:00

abstract：OBJECTIVES:Humoral immune response to SARS-CoV-2 infection has been reported in several patient cohorts with results that vary by method and population studied due to the lack of reliable commercial assays available as the pandemic initially spread. We sought to clinically assess commercial prototype SARS-CoV-2 IgG and...

journal_title：Clinical biochemistry

authors： Wheeler SE,Shurin GV,Keetch C,Mitchell G,Kattel G,McBreen J,Shurin MR

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND:Genetic variations of UDP-glucuronyltransferase 1A1 (UGT1A1) influence the concentration of serum bilirubin. We investigated the association of four common polymorphisms including UGT1A1-53(TA)(n), and common haplotypes of the UGT1A1 gene with bilirubin levels in 218 Caucasian volunteers. METHODS:Total bili...

journal_title：Clinical biochemistry

authors： Borucki K,Weikert C,Fisher E,Jakubiczka S,Luley C,Westphal S,Dierkes J

更新日期：2009-11-01 00:00:00

abstract：:Comparison of the turbidimetric immunoassay of haptoglobin with a reference method (the RID technique with appropriate correction for phenotype) clearly showed the turbidimetric assay to be phenotype-dependent. Correction factors for the three main phenotypes were calculated and reference values determined. The observ...

journal_title：Clinical biochemistry

authors： van Rijn HJ,van der Wilt W,Stroes JW,Schrijver J

更新日期：1987-08-01 00:00:00

abstract：OBJECTIVES:The aim was to study the influence of sampling time, food intake and sleep on tests used to screen for and monitor conditions of iron deficiency and overload. DESIGN AND METHODS:The 24 h variations of iron, transferrin, transferrin saturation (TS) and ferritin were studied in seven healthy individuals durin...

journal_title：Clinical biochemistry

authors： Ridefelt P,Larsson A,Rehman JU,Axelsson J

更新日期：2010-11-01 00:00:00

abstract：OBJECTIVES:To examine the diagnostic validity of bone alkaline phosphatase (BAP) in serum (a marker of bone formation) and of urinary excretion of pyridinium cross-links (PYR) (a marker of bone resorption) for detection of bone metastases. DESIGN AND METHODS:Two heterogeneous immunoassays were employed for determinati...

journal_title：Clinical biochemistry

authors： Withold W,Georgescu G,Khakzad H,Vosberg H,Mueller-Gaertner HW,Reinauer H

更新日期：1995-10-01 00:00:00

abstract：BACKGROUND:In several studies, it was shown that there was a marked decrease in serum levels of HDL-C during infection and inflammation in general. In particular, a decrease in the level of serum HDL-C was also shown in pneumonia. Correlations between inflammatory markers such as acute phase proteins, cytokines and ser...

journal_title：Clinical biochemistry

authors： Deniz O,Tozkoparan E,Yaman H,Cakir E,Gumus S,Ozcan O,Bozlar U,Bilgi C,Bilgic H,Ekiz K

更新日期：2006-03-01 00:00:00

abstract：:An affinity chromatographic method (AC) was compared with ion exchange chromatography (IEC) for determination of glycated hemoglobin (gHb). In vitro, increasing glucose concentration produced no change on AC-determined gHb. gHb measurement by AC was highly correlated with mean blood glucose (r = 0.96). Mean values of ...

journal_title：Clinical biochemistry

authors： Wettre S,von Schenck H

更新日期：1986-12-01 00:00:00

abstract：OBJECTIVES:Define performance characteristics of the Stratus CS cardiac troponin I (cTnI) assay in routine practice. METHODS:Imprecision at low cTnI values was assessed according to NCCLS EP5-A. Linearity was assessed by regression analysis; the reference interval was determined in 345 healthy individuals. Minimum det...

journal_title：Clinical biochemistry

authors： Christenson RH,Cervelli DR,Bauer RS,Gordon M

更新日期：2004-08-01 00:00:00

abstract：OBJECTIVES:We evaluated the effects of lifestyle modification (LM) on lipid profile, oxidative stress and serum-stimulated human coronary artery endothelial cell (HCAEC) viability in coronary artery disease (CAD) patients after 6months. DESIGN AND METHODS:Thirty patients with CAD were randomly assigned to LM intervent...

journal_title：Clinical biochemistry

authors： Srimahachota S,Wunsuwan R,Siritantikorn A,Boonla C,Chaiwongkarjohn S,Tosukhowong P

更新日期：2010-07-01 00:00:00

abstract：BACKGROUND:Laboratory confirmation of alpha-1-antitrypsin (A1AT) deficiency may be achieved by multiple methods. Here, we compare the relative comprehensiveness and efficiency of pathogenic variant (PV) detection of four different protocols utilized at different diagnostic centres in Canada. METHODS:Diagnostic results...

journal_title：Clinical biochemistry

authors： Mattman A,Gilfix BM,Chen SX,DeMarco ML,Kyle BD,Parker ML,Agbor TA,Jung B,Selvarajah S,Barakauskas VE,Vaags AK,Estey MP,Nelson TN,Speevak MD

更新日期：2020-07-01 00:00:00

abstract：UNLABELLED:Chronic liver diseases may cause inflammation and progressive scarring, over time leading to irreversible hepatic damage (cirrhosis). As a result, the need to assess and closely monitor individuals for risk factors of components of matrix deposition and degradation, as well as the severity of the fibrosis us...

journal_title：Clinical biochemistry

authors： Neuman MG,Cohen LB,Nanau RM

更新日期：2016-02-01 00:00:00

abstract：:A method is described for xylose determination on the Ciba-Corning 550 Express that utilizes the slower enzymatic action of glucose dehydrogenase (GDH) on D-xylose, after prior removal of glucose. Glucose oxidase is added to serum or urine and incubated for 120 min at 37 degrees C. After incubation, a perchloric acid ...

journal_title：Clinical biochemistry

authors： Mori L

更新日期：1994-02-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to determine the adult reference values for cystatin C (CysC) and to evaluate their consistence with those reported in the literature. DESIGN AND METHODS:CysC was analyzed in a consecutive series of subjects (100 males and 100 females) by a nephelometric immunoassay. Medline was sea...

journal_title：Clinical biochemistry

authors： Croda-Todd MT,Soto-Montano XJ,Hernández-Cancino PA,Juárez-Aguilar E

更新日期：2007-09-01 00:00:00

abstract：:Plasma, erythrocyte, and leucocyte magnesium (Mg) concentration, as well as urinary Mg, calcium (Ca), and phosphorus (P) excretion were determined in male subjects with elevated diastolic blood pressure (DBP) > 90 mmHg. These parameters were compared to those in normotensive age-matched (DBP < 85 mmHg) and drug-treate...

journal_title：Clinical biochemistry

authors： Fischer PW,Belonje B,Giroux A

更新日期：1993-06-01 00:00:00

abstract：OBJECTIVES:Molecular screening plays a major role in prognostic categorization and subsequent definition of treatment strategies for acute myeloid leukemia. The possibility of using IDH1/2 mutations as a marker for the monitoring of minimal residual disease (MRD) is still under investigation and remains unclear. METHO...

journal_title：Clinical biochemistry

authors： Petrova L,Vrbacky F,Lanska M,Zavrelova A,Zak P,Hrochova K

更新日期：2018-11-01 00:00:00

abstract：OBJECTIVES:We have comparatively evaluated respiratory burst and some steps of its signaling in human granulocytes towards different stimuli. MATERIALS AND METHODS:An alternative method to remove erythrocytes by dextran differential sedimentation was employed. Respiratory burst (RB) was assessed in a flow cytometer by...

journal_title：Clinical biochemistry

authors： Lunardi F,Lima JH,Assreuy J

更新日期：2006-01-01 00:00:00

abstract：:The clinical role of HER-2/neu, a 185 kD epithelial transmembranous protein, has evolved after the approval of the anti-HER-2/neu targeted monoclonal antibody trastuzumab (Herceptin) for the therapy of metastatic breast cancer. The extracellular domain of HER-2/neu undergoes proteolytic cleavage from the full-length p...

journal_title：Clinical biochemistry

authors： Lüftner D,Lüke C,Possinger K

更新日期：2003-06-01 00:00:00

abstract：OBJECTIVES:The plasma apolipoprotein B (apo B) concentrations have been considered to be a more accurate representation of atherogenic particles and it has been proposed that the formula LDL-C (mmol/L) = 0.41TC - 0.32TG + 1.70apo B - 0.27 is reliable for the estimation of LDL-C (Clin Chem 1997; 43: 808-15). We undertoo...

journal_title：Clinical biochemistry

authors： Bairaktari E,Hatzidimou K,Tzallas C,Vini M,Katsaraki A,Tselepis A,Elisaf M,Tsolas O

更新日期：2000-10-01 00:00:00

abstract：OBJECTIVES:Does abnormal betaine excretion persist? DESIGN AND METHODS:Patients (10) with abnormal excretion in 1998 were recalled in 2005. Subsequent urine samples were collected on 4 days from persistently abnormal subjects. RESULTS:Half the 1998 abnormal patients were abnormal in 2005. Only 1/20 controls was abnor...

journal_title：Clinical biochemistry

authors： Lever M,Atkinson W,George PM,Chambers ST

更新日期：2007-07-01 00:00:00

abstract：:An immunosuppressive substance was isolated from ascitic fluids of patients with advanced colon cancer by means of ammonium sulphate precipitation and preparative isoelectric focusing. This was a glycoprotein with an isoelectric point of pH 2.7-3.3, a molecular weight of about 52,000, and a sedimentation coefficient o...

journal_title：Clinical biochemistry

authors： Fujii M,Takahashi N,Hayashi H,Matsunaga K,Yoshikumi C

更新日期：1987-06-01 00:00:00

abstract：:The bromocresol purple (BCP) albumin method on the DuPont aca was evaluated by determining the accuracy and precision of the method. A split sample comparison was performed against the electroimmunoassay (EIA) method as well as the bromocresol green (BCG) method on the DuPont aca and the Technicon SMA 12/60. The BCP m...

journal_title：Clinical biochemistry

authors： Krahn J

更新日期：1983-04-01 00:00:00

abstract：:The field of miRNA research is evolving at a very fast pace. Since their discovery almost 20years ago, miRNAs have proven to be of tremendous importance to normal physiological homeostasis as well as to the pathogenesis of major diseases such as cancer. Recent advances describe a key contribution for miRNAs in a wide ...

journal_title：Clinical biochemistry

authors： Tétreault N,De Guire V

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND:Vitamin D-binding protein (DBP) is the main systemic transporter of 1.25(OH)2D3 and is essential for its cellular endocytosis. There are two known polymorphisms in exon 11 of the DBP gene resulting in amino acid variants: GAT-->GAG substitution replaces aspartic acid by glutamic acid in codon 416; and ACG-->...

journal_title：Clinical biochemistry

authors： Ongagna JC,Pinget M,Belcourt A

更新日期：2005-05-01 00:00:00