Abstract：
OBJECTIVE:To evaluate relationships between apolipoprotein B (Apo B), LDL cholesterol (LDL-C), and non-HDL-C in high-risk patients treated with lipid-lowering therapy. DESIGN AND METHODS:This post-hoc analysis calculated LDL-C and non-HDL-C levels corresponding to an Apo B of 0.9 g/L following treatment with 1) statin monotherapy (baseline) and 2) ezetimibe/simvastatin 10/20mg or rosuvastatin 10mg (study end). The percentages of patients reaching LDL-C, non-HDL-C, and Apo B targets were calculated at study end. RESULTS:After switching to ezetimibe/simvastatin or rosuvastatin, the LDL-C and non-HDL-C corresponding to Apo B=0.9 g/L were closer to the more aggressive LDL-C and non-HDL-C goals (1.81 and 2.59 mmol/L, respectively). Only slightly >50% of the patients who reached minimum recommended LDL-C or non-HDL-C at study end also had an Apo B level <0.9 g/L with both treatments. CONCLUSION:The use of Apo B for monitoring the efficacy of lipid-altering therapy would likely lead to more stringent criteria for lipid lowering.
journal_name
Clin Biochemjournal_title
Clinical biochemistryauthors
Vaverkova H,Farnier M,Averna M,Missault L,Viigimaa M,Dong Q,Shah A,Johnson-Levonas AO,Brudi Pdoi
10.1016/j.clinbiochem.2011.02.008subject
Has Abstractpub_date
2011-06-01 00:00:00pages
627-34issue
8-9eissn
0009-9120issn
1873-2933pii
S0009-9120(11)00070-1journal_volume
44pub_type
杂志文章,多中心研究,随机对照试验abstract：OBJECTIVES:In a previous publication, we had presented a sensitive method to detect mutations of the segment of the human glucocorticoid receptor alpha (hGRalpha) gene encoding the ligand binding domain (LBD) and part of the DNA binding domain (DBD) of hGRalpha, as several types of glucocorticoid resistance syndromes h...
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pub_type： 杂志文章
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更新日期：1993-08-01 00:00:00
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journal_title：Clinical biochemistry
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更新日期：2021-02-01 00:00:00
