Switching from statin monotherapy to ezetimibe/simvastatin or rosuvastatin modifies the relationships between apolipoprotein B, LDL cholesterol, and non-HDL cholesterol in patients at high risk of coronary disease.


OBJECTIVE:To evaluate relationships between apolipoprotein B (Apo B), LDL cholesterol (LDL-C), and non-HDL-C in high-risk patients treated with lipid-lowering therapy. DESIGN AND METHODS:This post-hoc analysis calculated LDL-C and non-HDL-C levels corresponding to an Apo B of 0.9 g/L following treatment with 1) statin monotherapy (baseline) and 2) ezetimibe/simvastatin 10/20mg or rosuvastatin 10mg (study end). The percentages of patients reaching LDL-C, non-HDL-C, and Apo B targets were calculated at study end. RESULTS:After switching to ezetimibe/simvastatin or rosuvastatin, the LDL-C and non-HDL-C corresponding to Apo B=0.9 g/L were closer to the more aggressive LDL-C and non-HDL-C goals (1.81 and 2.59 mmol/L, respectively). Only slightly >50% of the patients who reached minimum recommended LDL-C or non-HDL-C at study end also had an Apo B level <0.9 g/L with both treatments. CONCLUSION:The use of Apo B for monitoring the efficacy of lipid-altering therapy would likely lead to more stringent criteria for lipid lowering.


Clin Biochem


Clinical biochemistry


Vaverkova H,Farnier M,Averna M,Missault L,Viigimaa M,Dong Q,Shah A,Johnson-Levonas AO,Brudi P




Has Abstract


2011-06-01 00:00:00














  • Simvastatin treatment reduces heat shock protein 60, 65, and 70 antibody titers in dyslipidemic patients: A randomized, double-blind, placebo-controlled, cross-over trial.

    abstract:OBJECTIVE:This study aimed to evaluate the effects of statin therapy on serum levels of antibodies to several specific heat shock proteins (HSPs) in dyslipidemic patients. DESIGN AND METHODS:Participants (n=102) were treated with simvastatin (40mg/day), or placebo in a randomized, double-blind, placebo-controlled, cro...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章,随机对照试验


    authors: Moohebati M,Bidmeshgi S,Azarpazhooh MR,Daloee MH,Ghayour-Mobarhan M,Tavallaie S,Amini M,Momenzadeh A,Sahebkar A,Paydar R,Rahsepar AA,Parizadeh SM,Akhlaghi S,Ferns GA

    更新日期:2011-02-01 00:00:00

  • Detection of glucosylsphingosine in dried blood spots for diagnosis of Gaucher disease by LC-MS/MS.

    abstract:INTRODUCTION:Gaucher disease (GD) is caused by a deficiency of β-glucosidase (GCase), leading to accumulation of glucosylceramide (GlcC) and glucosylsphingosine (Lyso-Gb1). Lyso-Gb1 is a reliable biomarker for GD. OBJECTIVES:This study aims to develop a simple, effective and accurate method for the screening and diagn...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Tang C,Jia X,Tang F,Liu S,Jiang X,Zhao X,Sheng H,Peng M,Liu L,Huang Y

    更新日期:2021-01-01 00:00:00

  • Method for monitoring of the protein amino group changes during carbonylation.

    abstract:OBJECTIVES:Carbonylation of the protein amino, guanidino and thiol groups is one of the important causes of vascular complications in diabetes. We developed a simple spectrophotometric method for monitoring of the changes in the protein amino group contents during carbonylation. DESIGN AND METHODS:The method is based ...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Aćimović JM,Jovanović VB,Veselinović MR,Srećković VD,Mandić LM

    更新日期:2011-08-01 00:00:00

  • High-performance liquid chromatographic method with column-switching and post-column reaction for determination of serotonin levels in platelet-poor plasma.

    abstract:OBJECTIVES:Measurement of serotonin concentrations in blood is considered to be important for the clinical studies of diseases involving vascular endothelial injury. We have developed a high-performance liquid chromatographic (HPLC) method for measurement of serotonin level in platelet-poor plasma (PPP). METHODS:Venou...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Hirowatari Y,Hara K,Kamihata H,Iwasaka T,Takahashi H

    更新日期:2004-03-01 00:00:00

  • A sensitive method for the determination of hydrochlorothiazide in serum by high pressure liquid chromatography.

    abstract::A high pressure liquid chromatographic method for the determination of hydrochlorothiazide in serum has been elaborated and verified in a blood level study in normal individuals given a single oral dose of 50 mg hydrochlorothiazide. Based on 5 ml of serum, the limit of detection of the method is 2 ng/ml. ...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Robinson WT,Cosyns L

    更新日期:1978-08-01 00:00:00

  • Serum calprotectin levels in elderly males and females without bacterial or viral infections.

    abstract:OBJECTIVES:Calprotectin is released from activated leukocytes and calprotectin can thus be used as a marker for leukocyte activation. Faeces calprotectin is not only used as a marker for inflammatory bowel disease but can also be used to detect leukocyte activation in other body fluids. The aim of the present study was...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Nilsen T,Sundström J,Lind L,Larsson A

    更新日期:2014-08-01 00:00:00

  • Screening for adenylosuccinate lyase deficiency using tandem mass spectrometry analysis of succinylpurines in neonatal dried blood spots.

    abstract:OBJECTIVES:Stable isotope dilution coupled with liquid chromatography-tandem mass spectrometry (LC-MS/MS) is the sensitive method for screening for various inherited metabolic disorders using dried blood spots (DBSs). We present a method for LC-MS/MS determination of succinyladenosine (SAdo) and succinylaminoimidazole ...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Zikanova M,Krijt J,Skopova V,Krijt M,Baresova V,Kmoch S

    更新日期:2015-01-01 00:00:00

  • Spectrophotometric study of total protein-albumin methods applied to cerebrospinal fluid.

    abstract::A spectrophotometric study was carried out for three proteins assays when modification of their serum procedures using bromcresol green, bromcresol purple and biuret reagents were applied to the determinations of total proteins and albumin in cerebrospinal fluids. A novel concentration device wherein the sample itself...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Artiss JD,Thibert RJ,Zak B

    更新日期:1981-02-01 00:00:00

  • Preanalytics in urinalysis.

    abstract::Urine contains an enormous amount of information. Well-standardized procedures for collection, transport, sample preparation and analysis should become the basis of an effective diagnostic strategy for urinalysis. As reproducibility of urinalysis has been greatly improved due to recent technological progress, preanaly...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章,评审


    authors: Delanghe JR,Speeckaert MM

    更新日期:2016-12-01 00:00:00

  • Using a simulation model to assess risk of false negative point-of-care urinary human chorionic gonadotropin device results due to high-dose hook interference.

    abstract:BACKGROUND:It is unclear if the point-of-care (POC) Clinitest hCG device is subject to high-dose hook interference from physiological concentrations of intact human chorionic gonadotropin (hCG), β-core fragment of hCG (hCGβcf), and hCG free β-subunit (hCGβ) found in urine during pregnancy. We used a simulation model to...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Milhorn D,Korpi-Steiner N

    更新日期:2015-02-01 00:00:00

  • Determination of serum vitamins 25-OH-D2 and 25-OH-D3 with liquid chromatography-tandem mass spectrometry using atmospheric pressure chemical ionization or electrospray source and core-shell or sub-2 μm particle columns: a comparative study.

    abstract:OBJECTIVE:Develop a simple LC-MS-MS method for determination of 25-hydroxymetabolites of vitamin D2 and D3 in serum. DESIGN AND METHODS:0.1 mL serum was mixed with 0.3 mL deproteinizing mixture containing two deuterated internal standards. Two LC-MS-MS systems were used: Waters Premier with an ESI source and a Hypersi...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Bogusz MJ,Al Enazi E,Tahtamoni M,Jawaad JA,Al Tufail M

    更新日期:2011-11-01 00:00:00

  • Random uncertainty of photometric determination of hemolysis index on the Abbott Architect c16000 platform.

    abstract:BACKGROUND:Automatic photometric determination of the hemolysis index (HI) on serum and plasma samples is central to detect potential interferences of in vitro hemolysis on laboratory tests. When HI is above an established cut-off for interference, results may suffer from a significant bias and undermine clinical relia...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Aloisio E,Carnevale A,Pasqualetti S,Birindelli S,Dolci A,Panteghini M

    更新日期:2018-07-01 00:00:00

  • Plasma creatinine as a determinant of plasma total homocysteine concentrations in the Hordaland Homocysteine Study: use of statistical modeling to determine reference limits.

    abstract:OBJECTIVES:We established population-based reference limits for plasma total homocysteine (tHcy) according to creatinine. DESIGN AND METHODS:In 7042 middle-aged and elderly subjects from the Hordaland Homocysteine Study, we used statistical modeling to establish nomograms for tHcy according to creatinine in the whole ...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Elshorbagy AK,Oulhaj A,Konstantinova S,Nurk E,Ueland PM,Tell GS,Nygård O,Vollset SE,Refsum H

    更新日期:2007-11-01 00:00:00

  • A simplified assay for serum 25-hydroxycalciferol.

    abstract::The measurement of serum 25-hydroxycalciferol (25-OH D) has proved to be a reliable index of the vitamin D nutritional status in man providing the renal 25-hydroxycalciferol-1 alpha-hydroxylase is functional. Since it is known that 25 OHD binds to alpha-globulins for its transport to the kidney, we have developed a co...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Delvin EE,Dussault M,Glorieux FH

    更新日期:1980-06-01 00:00:00

  • The thyroid stimulating hormone receptor in human disease.

    abstract::The initial step in the action of thyrotropin (TSH) is its binding to the TSH receptor. TSH receptor antibodies are detected in up to 90% of patients with Graves' disease. Serial measurements of TSH receptor antibodies in patients with Graves' hyperthyroidism are helpful in predicting relapse. The TSH receptor was pur...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Harrison LC,Leedman PJ

    更新日期:1990-02-01 00:00:00

  • Application of fluorescence polarization to the determination of urinary lysozyme activity.

    abstract::A fluorescence polarization (FP) technique was applied to the assay of lysozyme activity in human urine. In this assay system, reaction between enzyme and fluorescein-labelled substrate produced a decrease in the fluorescein polarization (P) value. Enzyme activity and rate of decrease of P value exhibited a hyperbolic...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Miura H

    更新日期:1985-02-01 00:00:00

  • Changes in pro-oxidant-antioxidant balance after bare metal and drug eluting stent implantation in patients with stable coronary disease.

    abstract:OBJECTIVES:In this study we aimed to assess the changes in pro-oxidant-antioxidant balance (PAB) after the placement of either a drug-eluting-stent (DES) or bare-metal-stent (BMS) in patients with stable coronary artery disease. DESIGN AND METHODS:Percutaneous coronary interventions (PCI) with either BMS or DES were u...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Falsoleiman H,Dehghani M,Moohebati M,Fazlinezhad A,Daloee MH,Alamdari DH,Esmaily HO,Parizadeh SM,Tavallaie S,Rahsepar AA,Paydar R,Kazemi-Bajestani SM,Pourghadam-Yari H,Parizad PA,Ghayour-Mobarhan M,Ferns GA

    更新日期:2011-02-01 00:00:00

  • Urinary beta-luteinizing hormone and beta-follicle stimulating hormone immunoenzymometric assays for population research.

    abstract:OBJECTIVE:We developed assays for measurement of urinary betaLH and betaFSH under collection and storage conditions typical of non-clinical research settings. DESIGN AND METHODS:IEMAs for free betaLH and total betaFSH were validated by standard methods. Stability of urinary betaLH and betaFSH was tested across freeze-...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Brindle E,Miller RC,Shofer JB,Klein NA,Soules MR,O'Connor KA

    更新日期:2006-11-01 00:00:00

  • Influence of reduction in the elution times on HPLC glycohaemoglobin results.

    abstract:OBJECTIVES:To compare HPLC methods with short and long elution times for HbA1c measurement in blood. METHODS:Comparison between G7-Tosoh (1.2 min); Bio-Rad-Variant-II-Turbo (1.3 min) and Arkray-HA-8160 (2.9 min). RESULTS:Passing-Bablok regression equations were: Y=0.17+0.96X; Y=-0.39+1.01X; Y=-0.40+1.0X and the means...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Leon-Justel A,Santotoribio JD,Dominguez-Pascual I,Delgado AL,Macias C,Herrera MT,Leal A,Mangas MA,Acosta D,Guerrero JM

    更新日期:2009-10-01 00:00:00

  • Plasma estrogens in the assessment of fetoplacental function.

    abstract::A retrospective study has been undertaken to assess the diagnostic value of plasma estriol (E3) determinations, as compared with determinations of other biochemical parameters, in predicting the outcome of pregnancy. The normal levels of plasma unconjugated and total E3 were determined on weekly samples obtained durin...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Kulkarni BD,O'Leary JA,Takagi RL,Avila TD,Jabamoni R

    更新日期:1981-06-01 00:00:00

  • Biochemical impact of a soccer match - analysis of oxidative stress and muscle damage markers throughout recovery.

    abstract:BACKGROUND:Exercise is a prone condition to enhanced oxidative stress and damage and the specific activity pattern of a soccer match may favour additional pro-oxidant redox alterations. To date, no studies have reported the impact of a soccer match on oxidative stress and muscle damage markers. AIM:To analyse the effe...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Ascensão A,Rebelo A,Oliveira E,Marques F,Pereira L,Magalhães J

    更新日期:2008-07-01 00:00:00

  • Spurious hyperbilirubinemia caused by naproxen.

    abstract:OBJECTIVE:To confirm that the naproxen metabolite O-desmethylnaproxen interferes with the Jendrassik and Grof method for total bilirubin and was a possible cause of spurious hyperbilirubinemia in a case of naproxen overdose. DESIGN AND METHODS:Plasma was spiked with naproxen or O-desmethylnaproxen before total and dir...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Al Riyami N,Zimmerman AC,Rosenberg FM,Holmes DT

    更新日期:2009-01-01 00:00:00

  • Long-term stability of biochemical markers in pediatric serum specimens stored at -80 °C: a CALIPER Substudy.

    abstract:OBJECTIVES:Pediatric serum samples collected from healthy children in the CALIPER (Canadian Laboratory Initiative in Pediatric Reference Interval) project are stored at -80 °C for various periods of time. This study aimed to determine the stability of chemistry, protein, and hormone analytes under these conditions. DE...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Brinc D,Chan MK,Venner AA,Pasic MD,Colantonio D,Kyriakopolou L,Adeli K

    更新日期:2012-07-01 00:00:00

  • Utility of CA 15-3 and CEA in monitoring breast cancer patients with bone metastases: special emphasis on "spiking" phenomena.

    abstract:OBJECTIVES:CA 15-3 and CEA are considered useful tumor markers in monitoring breast cancer patients. This study was undertaken to specifically evaluate the transient elevations in these markers that are observed during systemic treatment for metastatic disease. This phenomenon has been termed "spiking." DESIGN AND MAT...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Yasasever V,Dinçer M,Camlica H,Karaloğlu D,Dalay N

    更新日期:1997-02-01 00:00:00

  • Recent advances of liquid chromatography-(tandem) mass spectrometry in clinical and forensic toxicology - An update.

    abstract::Liquid chromatography (LC) coupled to mass spectrometry (MS) or tandem mass spectrometry (MS/MS) is a well-established and widely used technique in clinical and forensic toxicology as well as doping control especially for quantitative analysis. In recent years, many applications for so-called multi-target screening an...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章,评审


    authors: Remane D,Wissenbach DK,Peters FT

    更新日期:2016-09-01 00:00:00

  • Detection of BRAF-V600E and V600K in melanoma circulating tumour cells by droplet digital PCR.

    abstract:OBJECTIVES:Defining the BRAF mutation status in metastatic melanoma patients is critical to selecting patients for therapeutic treatment with targeted therapies. Circulating tumour cells (CTCs) can provide an alternative source of contemporaneous tumour genetic material. However methodologies to analyse the presence of...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Reid AL,Freeman JB,Millward M,Ziman M,Gray ES

    更新日期:2015-10-01 00:00:00

  • High-throughput online solid-phase extraction tandem mass spectrometry: Is it right for your clinical laboratory?

    abstract::With increasing patient volumes and growing demands for rapid turnaround on many clinical tests, there is a demand for high-throughput technologies. High-Throughput Online Solid-Phase Extraction Tandem Mass Spectrometry is an example of one technology that can achieve these desired results and the RapidFire 365 Mass S...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Jannetto PJ,Langman LJ

    更新日期:2016-09-01 00:00:00

  • Advantage of salivary cortisol measurements in the diagnosis of glucocorticoid related disorders.

    abstract:OBJECTIVE:Salivary cortisol in the assessment of glucocorticoid related disorders. DESIGN-METHODS: Serum and salivary cortisol were measured in 189 patients (22 Cushing's syndrome, 67 pseudo-Cushing, 11 Addison's disease, 89 controls) at 8:00 and 24:00 h. RESULTS:Serum and salivary cortisol correlated in the whole stu...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Restituto P,Galofré JC,Gil MJ,Mugueta C,Santos S,Monreal JI,Varo N

    更新日期:2008-06-01 00:00:00

  • Prevalence of biotin supplement usage in outpatients and plasma biotin concentrations in patients presenting to the emergency department.

    abstract:BACKGROUND:Several cases of biotin interference with laboratory testing have been reported in the literature. However, there are no publications discussing the extent of biotin use or plasma concentrations observed among the patient population. The objective of this study was to determine the prevalence of biotin consu...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Katzman BM,Lueke AJ,Donato LJ,Jaffe AS,Baumann NA

    更新日期:2018-09-01 00:00:00

  • Establishment of reference intervals of 24 chemistries in apparently healthy adult Han population of Northern China.

    abstract:BACKGROUND:The availability of reference intervals is essential for physicians to interpret laboratory results. Most of our laboratory reference intervals are derived from data on the foreign population. We have studied the reference intervals of 24 common laboratory biochemical tests in an apparently healthy adult Han...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Yang S,Qiao R,Li Z,Wu Y,Yao B,Wang H,Cui L,Yang Y,Zhang J

    更新日期:2012-10-01 00:00:00