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Recent advances of liquid chromatography-(tandem) mass spectrometry in clinical and forensic toxicology - An update.

Abstract：

:Liquid chromatography (LC) coupled to mass spectrometry (MS) or tandem mass spectrometry (MS/MS) is a well-established and widely used technique in clinical and forensic toxicology as well as doping control especially for quantitative analysis. In recent years, many applications for so-called multi-target screening and/or quantification of drugs, poisons, and or their metabolites in biological matrices have been developed. Such methods have proven particularly useful for analysis of so-called new psychoactive substances that have appeared on recreational drug markets throughout the world. Moreover, the evolvement of high resolution MS techniques and the development of data-independent detection modes have opened new possibilities for applications of LC-(MS/MS) in systematic toxicological screening analysis in the so called general unknown setting. The present paper will provide an overview and discuss these recent developments focusing on the literature published after 2010.

journal_name

Clin Biochem

journal_title

Clinical biochemistry

authors

Remane D,Wissenbach DK,Peters FT

doi

10.1016/j.clinbiochem.2016.07.010

subject

Has Abstract

pub_date

2016-09-01 00:00:00

pages

1051-71

issue

13-14

eissn

0009-9120

issn

1873-2933

pii

S0009-9120(16)30167-9

journal_volume

49

pub_type

杂志文章,评审

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