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Oxidative imbalance in low/intermediate-1-risk myelodysplastic syndrome patients: The influence of iron overload.

Abstract：

OBJECTIVE:To assess the generation of reactive oxygen species (ROS) and the involvement of the main antioxidant pathways in low/intermediate-1-risk myelodysplastic syndromes (MDS) with iron overload (IOL). METHODS:We examined the levels of superoxide anion (O2-), hydrogen peroxide (H2O2), antioxidants (glutathione, GSH; superoxide dismutase, SOD; catalase, CAT; and glutathione peroxidase, GPx), mitochondrial membrane potential (ΔΨm), and by-products of oxidative damage (8-isoprostanes and 8-oxo-7,8-dihydro-2'-deoxyguanosine, 8-oxo-dG) in 42 MDS patients (28 without IOL at diagnosis, and 14 who developed IOL) and 20 healthy subjects. RESULTS:Patients with IOL showed higher O2- levels (39.4 MFI) than normal controls (22.7 MFI, p=0.0356) and patients at diagnosis (19.4 MFI, p=0.0049). Antioxidant systems, except SOD activity, exhibited significant changes in IOL patients with respect to controls (CAT: 7.1 vs 2.7nmol/ml/min, p=0.0023; GPx: 50.9 vs 76.4nmol/ml/min, p=0.0291; GSH: 50.2 vs 24.1 MFI, p=0.0060). Furthermore, mitochondrial dysfunction was only detected in IOL cases compared to controls (ΔΨm: 3.6 vs 6.4 MFI, p=0.0225). Finally, increased levels of 8-oxo-dG were detected in both groups of patients. CONCLUSION:Oxidative stress is an important but non-static phenomenon in MDS disease, whose status is influenced by, among other factors, the presence of injurious iron.

journal_name

Clin Biochem

journal_title

Clinical biochemistry

authors

Ivars D,Orero MT,Javier K,Díaz-Vico L,García-Giménez JL,Mena S,Tormos C,Egea M,Pérez PL,Arrizabalaga B,Ruiz MÁ,Yagüe N,Tormo M,Sancho-Tello R,Gomes A,Algueró C,O'Connor JE,Sáez GT,Carbonell F,Collado R

doi

10.1016/j.clinbiochem.2017.05.018

subject

Has Abstract

pub_date

2017-11-01 00:00:00

pages

911-917

issue

16-17

eissn

0009-9120

issn

1873-2933

pii

S0009-9120(17)30037-1

journal_volume

50

pub_type

杂志文章

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