Spurious hyperbilirubinemia caused by naproxen.


OBJECTIVE:To confirm that the naproxen metabolite O-desmethylnaproxen interferes with the Jendrassik and Grof method for total bilirubin and was a possible cause of spurious hyperbilirubinemia in a case of naproxen overdose. DESIGN AND METHODS:Plasma was spiked with naproxen or O-desmethylnaproxen before total and direct bilirubin analysis. RESULTS:O-desmethylnaproxen concentration showed a linear relationship with measured total bilirubin. CONCLUSION:O-demethylnaproxen interferes with the total bilirubin method. Interference of glucuronide metabolites of naproxen and O-demethylnaproxen is not excluded.


Clin Biochem


Clinical biochemistry


Al Riyami N,Zimmerman AC,Rosenberg FM,Holmes DT




Has Abstract


2009-01-01 00:00:00














  • A semi-automated enzymatic assay for free glycerol and triglycerides in serum or plasma.

    abstract::1. A relatively inexpensive semi-automated enzymatic procedure is described for the determination of total glycerol with an Auto Analyzer. Free glycerol is determined without saponification in a deproteinized supernatant. 2. The dilution of triglyceride samples during preparation is such that the samples during prepar...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: MacRae AR

    更新日期:1977-02-01 00:00:00

  • Quantifying MMA by SLE LC-MS/MS: Unexpected challenges in assay development.

    abstract:OBJECTIVES:Analysis of serum/plasma methylmalonic acid (MMA) is important for the diagnosis and management of methylmalonic acidemia in pediatric populations. This work focuses on developing and validating a liquid chromatography tandem mass spectrometry (LC-MS/MS) method to monitor methylmalonic acidemia using a simpl...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Lo SY,Gordon C,Sadilkova K,Jack RM,Dickerson JA

    更新日期:2016-09-01 00:00:00

  • Expression analysis and clinical utility of L-Dopa decarboxylase (DDC) in prostate cancer.

    abstract:BACKGROUND:L-Dopa decarboxylase (DDC) is a pyridoxal 5'-phosphate-dependent enzyme that was found to be involved in many malignancies. The aim of this study was to investigate the mRNA expression levels of DDC in prostate tissues and to evaluate its clinical utility in prostate cancer (CaP). METHODS:Total RNA was isol...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Avgeris M,Koutalellis G,Fragoulis EG,Scorilas A

    更新日期:2008-10-01 00:00:00

  • Relationship between serum butyrylcholinesterase and the metabolic syndrome.

    abstract:OBJECTIVE:To identify independent predictors of serum butyrylcholinesterase (BuChE) activity and examine its relationship with the metabolic syndrome. DESIGN AND METHODS:Serum BuChE activity was measured and metabolic syndrome risk factors were assessed in 1097 healthy subjects recruited from the Newfoundland adult po...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Randell EW,Mathews MS,Zhang H,Seraj JS,Sun G

    更新日期:2005-09-01 00:00:00

  • Vitamins D and A can be successfully measured by LC-MS/MS in cord blood diluted plasma.

    abstract:OBJECTIVES:In widely used protocols for the collection and isolation of cord blood mononuclear cells, investigators are left with substantial volumes of diluted plasma which could be used for other measurements. The aim of this study was to ascertain the validity of umbilical cord blood (UCB) diluted plasma samples for...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Albarhani AA,Collier F,Greaves RF,Ponsonby AL,Allen KJ,Vuillermin PJ,Roche P,Clarke MW,BIS Steering Committee.

    更新日期:2015-11-01 00:00:00

  • CRISPR-based tools: Alternative methods for the diagnosis of COVID-19.

    abstract::The recently emerged severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) spread all over the world rapidly and caused a global pandemic. To prevent the virus from spreading to more individuals, it is of great importance to identify and isolate infected individuals through testing. Reverse transcription-quanti...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章,评审


    authors: Palaz F,Kalkan AK,Tozluyurt A,Ozsoz M

    更新日期:2021-01-09 00:00:00

  • Effect of whole soy and purified isoflavone daidzein on renal function--a 6-month randomized controlled trial in equol-producing postmenopausal women with prehypertension.

    abstract:OBJECTIVES:The aim of the study was to examine the long-term effect of commonly used whole soy foods (soy flour) and purified daidzein (one major isoflavone and the precursor of equol) on renal function among prehypertensive postmenopausal women who are also equol producers, a population most likely to benefit from soy...

    journal_title:Clinical biochemistry

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Liu ZM,Ho SC,Chen YM,Tang N,Woo J

    更新日期:2014-09-01 00:00:00

  • Type 1-prophospholipase A2 propeptide immunoreactivity is released from activated granulocytes.

    abstract:OBJECTIVE:To establish a ELISA assay to measure release of type 1-phospholipase A2 propeptide from activated granulocytes. Human type 1-prophospholipase A2 (1-proPLA2) is biosynthesized and stored as inactive zymogen. Activation involves tryptic-like cleavage at the N-terminus, with equimolar release of the heptapeptid...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Rae D,Sumar N,Beechey-Newman N,Gudgeon M,Hermon-Taylor J

    更新日期:1995-02-01 00:00:00

  • Elevated hemoglobin A1 in streptozotocin diabetic rats and in rats on sucrose and galactose-enriched diets.

    abstract::Increased hemoglobin A1 (HbA1) occurs in diabetes mellitus as a direct consequence of hyperglycemia, which causes postsynthetic modification of hemoglobin proportional to blood glucose concentration. Glycosylation of hemoglobin is demonstrable also in vitro, not only by glucose, but with other reducing sugars such as ...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Powell HC,Ivor LP,Costello ML,Wolf PL

    更新日期:1982-06-01 00:00:00

  • Development of an Au/ZnO thin film surface plasmon resonance-based biosensor immunoassay for the detection of carbohydrate antigen 15-3 in human saliva.

    abstract:OBJECTIVE:To evaluate a novel surface plasmon resonance (SPR) system for the direct measurement of tumor marker carbohydrate antigen 15-3 (CA15-3) in human saliva. DESIGN AND METHODS:We measured the presence of the tumor marker carbohydrate antigen 15-3 (CA15-3) in human saliva using 2 different surface plasmon resona...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Liang YH,Chang CC,Chen CC,Chu-Su Y,Lin CW

    更新日期:2012-12-01 00:00:00

  • Using a simulation model to assess risk of false negative point-of-care urinary human chorionic gonadotropin device results due to high-dose hook interference.

    abstract:BACKGROUND:It is unclear if the point-of-care (POC) Clinitest hCG device is subject to high-dose hook interference from physiological concentrations of intact human chorionic gonadotropin (hCG), β-core fragment of hCG (hCGβcf), and hCG free β-subunit (hCGβ) found in urine during pregnancy. We used a simulation model to...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Milhorn D,Korpi-Steiner N

    更新日期:2015-02-01 00:00:00

  • Method for monitoring of the protein amino group changes during carbonylation.

    abstract:OBJECTIVES:Carbonylation of the protein amino, guanidino and thiol groups is one of the important causes of vascular complications in diabetes. We developed a simple spectrophotometric method for monitoring of the changes in the protein amino group contents during carbonylation. DESIGN AND METHODS:The method is based ...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Aćimović JM,Jovanović VB,Veselinović MR,Srećković VD,Mandić LM

    更新日期:2011-08-01 00:00:00

  • Significant, quantifiable differences exist between IgG subclass standards WHO67/97 and ERM-DA470k and can result in different interpretation of results.

    abstract:OBJECTIVES:Accurate measurement of IgG subclass (IgGSc) levels are essential to aid in the diagnosis of disease states such as primary immunodeficiencies. However, there is no single standardisation of nephelometric and turbidimetric assays for these analytes and two reference materials have been utilised. We expand on...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Wilson C,Ebling R,Henig C,Adler T,Nicolaevski R,Barak M,Cazabon J,Maisin D,Lepoutre T,Gruson D,Hughes RG,Parker AR

    更新日期:2013-11-01 00:00:00

  • miRNA in clinical practice: pancreatic cancer.

    abstract::To date, pancreatic cancer (PDAC) can't be diagnosed early. Consequently, a majority of patient (80%) display an advanced disease that results in a low resection rate leading to an overall median survival of 4 to 6months. Accordingly, robust markers for the early diagnosis and prognosis of pancreatic cancer, or marker...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章,评审


    authors: Humeau M,Torrisani J,Cordelier P

    更新日期:2013-07-01 00:00:00

  • Characterizing urinary hCGβcf patterns during pregnancy.

    abstract:OBJECTIVE:Elevated concentrations of hCG beta core fragment (hCGβcf) are known to cause false-negative results in qualitative urine pregnancy test devices, but the pattern of urinary hCGβcf during normal pregnancy has not been well characterized. Here, we evaluate the relationship between urine hCG, hCGβcf, and hCG fre...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章,随机对照试验


    authors: Nerenz RD,Yarbrough ML,Stenman UH,Gronowski AM

    更新日期:2016-07-01 00:00:00

  • Study of FibroTest and hyaluronic acid biological variation in healthy volunteers and comparison of serum hyaluronic acid biological variation between chronic liver diseases of different etiology and fibrotic stage using confidence intervals.

    abstract:OBJECTIVES:Personalized ranges of liver fibrosis serum biomarkers such as FibroTest or hyaluronic acid could be used for early detection of fibrotic changes in patients with progressive chronic liver disease. Our aim was to generate reliable biological variation estimates for these two biomarkers with confidence interv...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Istaces N,Gulbis B

    更新日期:2015-07-01 00:00:00

  • A correlation of serum bile acid levels with conventional biochemical parameters in the assessment of hepatobiliary dysfunctions.

    abstract::In hepatobiliary disease, the level of bile acids in the peripheral circulation is greatly increased due to impaired liver function. It has been suggested that serum bile acids are of greater value in confirming hepatobiliary dysfunction than the currently assayed conventional biochemical parameters. Fifty patients wi...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Jarzabek JI,Kampa IS

    更新日期:1981-12-01 00:00:00

  • Ensuring suitable quality of clinical measurements through design.

    abstract::To design and deliver high quality, safe and effective products, manufacturers of in vitro diagnostic (IVD) products follow a structured, traceable process for controlling the uncertainty of results reported from their measurement systems. This process and its results however, are not often shared in detail with those...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Orzechowski A,Petrides V,Scopp R

    更新日期:2018-07-01 00:00:00

  • An acid hydrolysis method for quantification of plasma free and total carnitine by flow injection tandem mass spectrometry.

    abstract:OBJECTIVES:To develop a tandem mass spectrometry (MS/MS) method for plasma free and total carnitine, incorporating acid hydrolysis for total carnitine measurement, for improved accuracy and sample throughput. DESIGN AND METHODS:Limit of detection (LOD), limit of quantitation (LOQ), linearity, accuracy, precision coeff...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Johnson DW

    更新日期:2010-11-01 00:00:00

  • Corrected Fructosamine improves both correlation with HbA1C and diagnostic performance.

    abstract:AIMS:There is increasing interest in using fructosamine measurements in screening for or managing diabetes, yet uncertainty remains as to whether these measurements should be corrected for variation in serum protein concentrations. METHODS:We considered all sets of simultaneous measurements of fructosamine, albumin, t...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Rodríguez-Segade S,Rodríguez J,Camiña F

    更新日期:2017-02-01 00:00:00

  • Endostatin predicts mortality in patients with acute dyspnea - A cohort study of patients seeking care in emergency departments.

    abstract:BACKGROUND:Increased levels of circulating endostatin predicts cardiovascular morbidity and impaired kidney function in the general population. The utility of endostatin as a risk marker for mortality in the emergency department (ED) has not been reported. AIM:Our main aim was to study the association between plasma e...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Carlsson AC,Wessman T,Larsson A,Leijonberg G,Tofik R,Ärnlöv J,Melander O,Ruge T

    更新日期:2020-01-01 00:00:00

  • Lipid peroxidation and antioxidant system in the blood of patients with Hodgkin's disease.

    abstract:OBJECTIVES:The purpose of this study was to measure the extent of lipid peroxidation and the status of antioxidants in patients with Hodgkin's disease. DESIGN AND METHODS:Glutathione peroxidase (GPX) and superoxide dismutase (SOD) activities, and malondialdehyde (MDA), selenium, zinc and copper content have been measu...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Güven M,Oztürk B,Sayal A,Ozet A

    更新日期:2000-04-01 00:00:00

  • Knee replacement surgery significantly elevates the urinary inflammatory biomarkers neopterin and 7,8-dihydroneopterin.

    abstract:CONTEXT:Knee arthroplasty surgery is significant trauma, leading to an activated immune system causing inflammation and oxidative stress. Many current biomarkers are invasive, costly, and often slow to analyse, limiting their use for rapid inflammatory measurements. OBJECTIVES:We have examined the use of urinary neopt...

    journal_title:Clinical biochemistry

    pub_type: 临床试验,杂志文章,多中心研究


    authors: Baxter-Parker G,Roffe L,Cross S,Frampton C,Hooper GJ,Gieseg SP

    更新日期:2019-01-01 00:00:00

  • Development of a direct DNA sequencing method for detecting heterozygous mutations of the human lipoprotein lipase gene.

    abstract:OBJECTIVE:The purpose of this study was to develop an improved method of direct DNA sequencing, which makes it possible to identify heterozygous mutations of the lipoprotein lipase (LPL) gene in order to understand the underlying genetic disorder of type IV hyperlipoproteinemia. METHODS AND RESULTS:The direct sequenci...

    journal_title:Clinical biochemistry

    pub_type: 临床试验,杂志文章


    authors: Mori A,Takagi A,Ikeda Y,Yamamoto A

    更新日期:1997-06-01 00:00:00

  • Performance characteristics of beta-2-microglobulin measurements on a Beckman Immage analyzer with the DakoCytomation reagent kit.

    abstract:OBJECTIVE:Evaluation of serum beta-2-microglobulin (beta2M) in an automated analyzer. DESIGN AND METHODS:The DakoCytomation beta2M kit is an antibody based reagent intended for quantitative determination of beta2M in serum and plasma by rate nephelometry. RESULTS:The limit of blank is 0.16 mg/L. The method is linear ...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: De BK,Jimenez E,De S

    更新日期:2009-10-01 00:00:00

  • Effects of non-pharmacological sympathetic sudomotor denervation on sweating in humans with essential palmar hyperhidrosis.

    abstract:OBJECTIVE:Quantitative sweat production and -ionic composition in Essential Hyperhidrosis (EH), and the effects of T2-T3 thoracoscopic sympathicolysis (TS) hereon, are unknown. Standardised pilocarpine iontophoresis sweat tests were performed before and after TS in order to study these issues. DESIGN AND METHODS:Piloc...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Noppen M,Sevens C,Vincken WG

    更新日期:1997-03-01 00:00:00

  • Establishment of reference intervals of 24 chemistries in apparently healthy adult Han population of Northern China.

    abstract:BACKGROUND:The availability of reference intervals is essential for physicians to interpret laboratory results. Most of our laboratory reference intervals are derived from data on the foreign population. We have studied the reference intervals of 24 common laboratory biochemical tests in an apparently healthy adult Han...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Yang S,Qiao R,Li Z,Wu Y,Yao B,Wang H,Cui L,Yang Y,Zhang J

    更新日期:2012-10-01 00:00:00

  • Amplification of intermediate-size DNA sequences from formalin and B-5 fixed tissue by polymerase chain reaction.

    abstract::Retrospective analysis of DNA from paraffin-embedded fixed bone marrow biopsy specimens is possible if preceded by amplification of the DNA sequences of interest by the polymerase chain reaction (PCR). These fixed specimens yield degraded DNA that may not be suitable for direct analysis by conventional digestion and h...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Crisan D,Mattson JC

    更新日期:1992-04-01 00:00:00

  • APOC3 -482C>T polymorphism, circulating apolipoprotein C-III and smoking: interrelation and roles in predicting type-2 diabetes and coronary disease.

    abstract:OBJECTIVES:We determined the relationship of smoking status on APOC3 -482C>T polymorphism and apolipoprotein C-III (apoC-III) concentrations and the latter two parameters' influence on risk of diabetes and coronary heart disease (CHD). DESIGN AND METHODS:Prediction of incident cases was assessed at 5.5years' follow-up...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Onat A,Erginel-Unaltuna N,Coban N,Ciçek G,Yüksel H

    更新日期:2011-04-01 00:00:00

  • The role of bone turnover markers in monitoring treatment in postmenopausal osteoporosis.

    abstract::Bone metabolism is assessed using biochemical bone turnover markers (BTM). BTM reflect the metabolic effect of drugs on bone turnover, help to establish the lowest dose inducing the largest change in the BTM, predict treatment-related reduction in fracture risk, and are helpful in bridging studies. Changes in BTM duri...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章,评审


    authors: Szulc P

    更新日期:2012-08-01 00:00:00