Spurious hyperbilirubinemia caused by naproxen.

Abstract:

OBJECTIVE:To confirm that the naproxen metabolite O-desmethylnaproxen interferes with the Jendrassik and Grof method for total bilirubin and was a possible cause of spurious hyperbilirubinemia in a case of naproxen overdose. DESIGN AND METHODS:Plasma was spiked with naproxen or O-desmethylnaproxen before total and direct bilirubin analysis. RESULTS:O-desmethylnaproxen concentration showed a linear relationship with measured total bilirubin. CONCLUSION:O-demethylnaproxen interferes with the total bilirubin method. Interference of glucuronide metabolites of naproxen and O-demethylnaproxen is not excluded.

journal_name

Clin Biochem

journal_title

Clinical biochemistry

authors

Al Riyami N,Zimmerman AC,Rosenberg FM,Holmes DT

doi

10.1016/j.clinbiochem.2008.09.119

subject

Has Abstract

pub_date

2009-01-01 00:00:00

pages

129-31

issue

1-2

eissn

0009-9120

issn

1873-2933

pii

S0009-9120(08)00523-7

journal_volume

42

pub_type

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