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Multiple atherosclerosis-related biomarkers associated with short- and long-term mortality after stroke.

Abstract：

OBJECTIVES:We investigated the relationships of biomarkers of various pathophysiologic pathways including high-sensitivity C-reactive protein (hs-CRP), lipocalin-2 (LCN2), myeloperoxidase (MPO) and matrix metalloproteinases 9 (MMP9) with mortality in stroke patients. DESIGN AND METHODS:hs-CRP, LCN2 and MPO concentrations in 92 patients were determined using enzyme-linked immunosorbent assays. MMP9 mRNA concentrations were determined using real-time quantitative reverse transcription-polymerase chain reaction. RESULTS:Twelve patients (13.0%) died at 6 months and 34 patients (37.0%) died at 5 years. The independent predictors for 6-month mortality were hs-CRP (adjusted OR=16.0) and LCN2 (adjusted OR=16.9), while for 5-year mortality was hs-CRP (adjusted OR=5.56). For patients with hs-CRP >3.4 mg/L, an increase in LCN2 was associated with 2.5-fold higher 6-month mortality, while an increase in normalized MMP9 mRNA was associated with 5.8-fold higher 6-month and 1.5-fold higher 5-year mortality. CONCLUSION:hs-CRP was the most significant independent predictor of both short- and long-term mortality after stroke, with LCN2 and MMP9 mRNA each adding further to the risk stratification.

journal_name

Clin Biochem

journal_title

Clinical biochemistry

authors

Chan CP,Jiang HL,Leung LY,Wan WM,Cheng NM,Ip WS,Cheung KY,Chan RW,Wong LK,Graham CA,Renneberg R,Rainer TH

doi

10.1016/j.clinbiochem.2012.06.014

subject

Has Abstract

pub_date

2012-11-01 00:00:00

pages

1308-15

issue

16-17

eissn

0009-9120

issn

1873-2933

pii

S0009-9120(12)00308-6

journal_volume

45

pub_type

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