当前位置： SCI文献检索 > CLINICAL BIOCHEMISTRY期刊下所有文献 > Simultaneous determination of glucose, triglycerides, urea, cholesterol, albumin and total protein in human plasma by Fourier transform infrared spectroscopy: direct clinical biochemistry without reagents.

Simultaneous determination of glucose, triglycerides, urea, cholesterol, albumin and total protein in human plasma by Fourier transform infrared spectroscopy: direct clinical biochemistry without reagents.

Abstract：

OBJECTIVE:Direct measurement of chemical constituents in complex biologic matrices without the use of analyte specific reagents could be a step forward toward the simplification of clinical biochemistry. Problems related to reagents such as production errors, improper handling, and lot-to-lot variations would be eliminated as well as errors occurring during assay execution. We describe and validate a reagent free method for direct measurement of six analytes in human plasma based on Fourier-transform infrared spectroscopy (FTIR). DESIGN AND METHODS:Blood plasma is analyzed without any sample preparation. FTIR spectrum of the raw plasma is recorded in a sampling cuvette specially designed for measurement of aqueous solutions. For each analyte, a mathematical calibration process is performed by a stepwise selection of wavelengths giving the optimal least-squares correlation between the measured FTIR signal and the analyte concentration measured by conventional clinical reference methods. The developed calibration algorithms are subsequently evaluated for their capability to predict the concentration of the six analytes in blinded patient samples. RESULTS:The correlation between the six FTIR methods and corresponding reference methods were 0.87

journal_name

Clin Biochem

journal_title

Clinical biochemistry

authors

Jessen TE,Höskuldsson AT,Bjerrum PJ,Verder H,Sørensen L,Bratholm PS,Christensen B,Jensen LS,Jensen MA

doi

10.1016/j.clinbiochem.2014.05.064

subject

Has Abstract

pub_date

2014-09-01 00:00:00

pages

1306-12

issue

13-14

eissn

0009-9120

issn

1873-2933

pii

S0009-9120(14)00331-2

journal_volume

47

pub_type

杂志文章

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