Does interferon and ribavirin combination therapy ameliorate growth hormone deficiency in HCV genotype-4 infected patients?

abstract：:Point of Care Testing (POCT) refers to clinical laboratory testing performed outside the central laboratory, nearer to the patient and sometimes at the patient bedside. The testing is usually performed by clinical staff, such as physicians or nurses, who are not laboratory trained. This document was developed by the P...

journal_title：Clinical biochemistry

authors： Venner AA,Beach LA,Shea JL,Knauer MJ,Huang Y,Fung AWS,Dalton J,Provencal M,Shaw JLV

更新日期：2021-02-01 00:00:00

abstract：OBJECTIVE:The relationship between the severity of atherosclerotic coronary artery disease (CAD) and circulating levels of salusin-α, salusin-β and heregulin-β1 has been investigated. In addition, the relationship with these peptides and high sensitive C-reactive protein (hsCRP) has been investigated. METHODS:The stud...

journal_title：Clinical biochemistry

authors： Arkan A,Atukeren P,Ikitimur B,Simsek G,Koksal S,Gelisgen R,Ongen Z,Uzun H

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND:Exercise is a prone condition to enhanced oxidative stress and damage and the specific activity pattern of a soccer match may favour additional pro-oxidant redox alterations. To date, no studies have reported the impact of a soccer match on oxidative stress and muscle damage markers. AIM:To analyse the effe...

journal_title：Clinical biochemistry

authors： Ascensão A,Rebelo A,Oliveira E,Marques F,Pereira L,Magalhães J

更新日期：2008-07-01 00:00:00

abstract：:Proteomics, the analysis of expressed proteins, has been an important developing area of research for the past two decades [Anderson, NG, Anderson, NL. Twenty years of two-dimensional electrophoresis: past, present and future. Electrophoresis 1996;17:443-453]. Advances in technology have led to a rapid increase in app...

journal_title：Clinical biochemistry

authors： Aldred S,Grant MM,Griffiths HR

更新日期：2004-11-01 00:00:00

abstract：:An immunosuppressive substance was isolated from ascitic fluids of patients with advanced colon cancer by means of ammonium sulphate precipitation and preparative isoelectric focusing. This was a glycoprotein with an isoelectric point of pH 2.7-3.3, a molecular weight of about 52,000, and a sedimentation coefficient o...

journal_title：Clinical biochemistry

authors： Fujii M,Takahashi N,Hayashi H,Matsunaga K,Yoshikumi C

更新日期：1987-06-01 00:00:00

abstract：UNLABELLED:Frozen biospecimens are crucial for translational research and contain well-preserved nucleic acids and protein. However, the risks of freezer failure as well as space, cost, and environmental concerns of frozen biospecimens are substantial. OBJECTIVE:The purpose of the study was to review the current statu...

journal_title：Clinical biochemistry

authors： Lou JJ,Mirsadraei L,Sanchez DE,Wilson RW,Shabihkhani M,Lucey GM,Wei B,Singer EJ,Mareninov S,Yong WH

更新日期：2014-03-01 00:00:00

abstract：:An ion-exchange chromatographic procedure is described which facilitates the determination of beta-chain aminoterminal modified glycated hemoglobin. The procedure includes an erythrocyte lysis reagent which eliminates the labile aldimine component (pre-A1c) and a two-stage elution step which separates HbA, 1a + b from...

journal_title：Clinical biochemistry

authors： Jaynes PK,Willis MC,Chou PP

更新日期：1985-02-01 00:00:00

abstract：OBJECTIVES:Defining the BRAF mutation status in metastatic melanoma patients is critical to selecting patients for therapeutic treatment with targeted therapies. Circulating tumour cells (CTCs) can provide an alternative source of contemporaneous tumour genetic material. However methodologies to analyse the presence of...

journal_title：Clinical biochemistry

authors： Reid AL,Freeman JB,Millward M,Ziman M,Gray ES

更新日期：2015-10-01 00:00:00

abstract：OBJECTIVES:The fibroblast growth factor receptor 3 gene (FGFR3) plays a critical role in cartilage growth-plate differentiation and bony development. It has been shown that 97% of patients with achondroplasia have a G to A transition mutation at position 1138 (c.1138 G>A) of codon 380 of the FGFR3 gene. DESIGN AND MET...

journal_title：Clinical biochemistry

authors： Hung CC,Lee CN,Chang CH,Jong YJ,Chen CP,Hsieh WS,Su YN,Lin WL

更新日期：2008-02-01 00:00:00

abstract：OBJECTIVES:Microarray analysis of gene expression profiles of blood leukocytes has many potential clinical and research applications. DESIGN AND METHODS:We used the PAXgene Blood RNA System to prepare RNA from the whole blood of normal volunteers using two incubation times followed by gene expression profiling using t...

journal_title：Clinical biochemistry

authors： Wang J,Robinson JF,Khan HM,Carter DE,McKinney J,Miskie BA,Hegele RA

更新日期：2004-09-01 00:00:00

abstract：:Steroids play an important role in sperm production and quality. These hormones have been extensively studied in blood, but poorly investigated in semen. The purpose of our study was to evaluate the relationship between sperm quality and steroid profiles in blood and semen in a small cohort of young Swiss men. Another...

journal_title：Clinical biochemistry

authors： Zufferey F,Rahban R,Garcia A,Gagnebin Y,Boccard J,Tonoli D,Jeanneret F,Stettler E,Senn A,Nef S,Rudaz S,Rossier MF

更新日期：2018-12-01 00:00:00

abstract：:We evaluated a method for quantifying bone isoenzyme of alkaline phosphatase (ALP) which utilizes wheat-germ lectin to precipitate this fraction. In precision studies, CVs ranged from 3.2 to 11.4% (within-day) and from 3.7 to 11.5% (day-to-day). The assay procedure was linear to 1100 U/L and was easily adapted to auto...

journal_title：Clinical biochemistry

authors： Burlina A,Plebani M,Secchiero S,Zaninotto M,Sciacovelli L

更新日期：1991-10-01 00:00:00

abstract：:Plasminogen activators (PAs) are specific proteolytic enzymes which convert the inactive proenzyme plasminogen to plasmin. The plasmin formed is a potent and nonspecific protease which cleaves blood fibrin clots and several other extracellular proteins. In addition to their primary role in the initiation of fibrinolys...

journal_title：Clinical biochemistry

authors： Mayer M

更新日期：1990-06-01 00:00:00

abstract：:Many clinical laboratories use the Beckman Microzone electrophoretic system (Beckman Instruments Inc. Fullerton, CA 92634) for serum protein separation. Although detailed instruction is supplied in the manufacturer's manual (1) for protein separation, the effect of different sample application positions on the cellulo...

journal_title：Clinical biochemistry

authors： Chu SY,Turkington VE

更新日期：1978-12-01 00:00:00

abstract：:The field of miRNA research is evolving at a very fast pace. Since their discovery almost 20years ago, miRNAs have proven to be of tremendous importance to normal physiological homeostasis as well as to the pathogenesis of major diseases such as cancer. Recent advances describe a key contribution for miRNAs in a wide ...

journal_title：Clinical biochemistry

authors： Tétreault N,De Guire V

更新日期：2013-07-01 00:00:00

abstract：OBJECTIVES:This study examines the redox status of drug-resistant epileptic patients and how it is modified after surgical treatment. DESIGN AND METHODS:The activity of antioxidant enzymes (superoxide dismutase, catalase and glutathione peroxidase), and markers of damage to biomolecules (malondialdehyde and advanced o...

journal_title：Clinical biochemistry

authors： López J,González ME,Lorigados L,Morales L,Riverón G,Bauzá JY

更新日期：2007-03-01 00:00:00

abstract：OBJECTIVES:This study explored the relationship between oxidative stress biomarkers and stability of carotid plaque. We decided to analyze the broad range of parameters describing oxidative stress in patients with carotid stenosis. DESIGN AND METHODS:124 consecutive patients undergoing carotid endarterectomy were enro...

journal_title：Clinical biochemistry

authors： Rozalski R,Migdalski A,Gackowski D,Guz J,Siomek A,Foksinski M,Szpila A,Zarakowska E,Majer M,Jawien A,Olinski R

更新日期：2013-08-01 00:00:00

abstract：UNLABELLED:Chronic liver diseases may cause inflammation and progressive scarring, over time leading to irreversible hepatic damage (cirrhosis). As a result, the need to assess and closely monitor individuals for risk factors of components of matrix deposition and degradation, as well as the severity of the fibrosis us...

journal_title：Clinical biochemistry

authors： Neuman MG,Cohen LB,Nanau RM

更新日期：2016-02-01 00:00:00

abstract：OBJECTIVES:The steroids estradiol (E2), estrone (E1), and estriol (E3) are the major estrogens. E1/E2 and their metabolite 16-hydroxyestrone (16-OHE1, known to be carcinogenic) could be involved in the development of many cancers including human breast cancer. The aim of the current study was to develop a rapid and sim...

journal_title：Clinical biochemistry

authors： Guo T,Gu J,Soldin OP,Singh RJ,Soldin SJ

更新日期：2008-06-01 00:00:00

abstract：OBJECTIVES:Lipoprotein(a) [Lp(a)] can be oxidized by copper in vitro in a way comparable to low-density lipoprotein (LDL). We sought to determine whether the susceptibility of Lp(a) to oxidation is correlated with the susceptibility of autologous heterogeneous LDL, with apolipoprotein(a) [apo(a)] molecular size, or wit...

journal_title：Clinical biochemistry

authors： Nakajima K,Yamashita T,Kusuhara M,Yonemura A,Ito T,Higashi K,Ayaori M,Ohmori R,Nakamura H,Ohsuzu F

更新日期：2003-03-01 00:00:00

abstract：BACKGROUND:Researchers are debating if fecal calprotectin results are useful for infant patients, especially in screening for necrotizing enterocolitis (NEC). Currently, none of the FDA-approved calprotectin assays provide a cut-off for infant patients. We retrospectively analyzed data from a reference laboratory and u...

journal_title：Clinical biochemistry

authors： Goold E,Pearson L,Johnson LM

更新日期：2020-10-01 00:00:00

abstract：OBJECTIVE:To characterize the lipid-related atherogenic risk factors in iron deficiency anaemia (IDA) patients. DESIGN AND METHODS:Twenty IDA women were compared to healthy age-matched controls. Lipoprotein profile, cholesteryl ester transfer protein (CETP), paraoxonase (PON) 1 and lipoprotein-associated phospholipase...

journal_title：Clinical biochemistry

authors： Meroño T,Sorroche P,Gómez Rosso LA,Casañas L,Boero LE,Arbelbide JA,Brites FD

更新日期：2010-03-01 00:00:00

abstract：:Lipoprotein lipase (LPL) of adipose cells is present only in membrane compartments, mainly in the Golgi apparatus. LPL is a typical secretory protein which appears to be active as a homodimer. The process of LPL synthesis and maturation requires multiple steps. LPL is synthesized in the endoplasmic reticulum as an ina...

journal_title：Clinical biochemistry

authors： Ailhaud G

更新日期：1990-10-01 00:00:00

abstract：OBJECTIVES:The aim of the present study was to establish the range of chitotriosidase (CT) activity in normal individuals, patients with Gaucher disease (GD) and Niemann-Pick disease (NPD), types A or B. The kinetics of CT in these three groups was also investigated. DESIGN AND METHODS:CT activity, as well as Km, Vmax...

journal_title：Clinical biochemistry

authors： Wajner A,Michelin K,Burin MG,Pires RF,Pereira ML,Giugliani R,Coelho JC

更新日期：2004-10-01 00:00:00

abstract：:In the urine of six subjects with a urea cycle disorder characterized by hyperammonemia, hyperornithinemia and homocitrullinuria, an unusual ninhydrin-reaction compound was encountered. This unknown on hydrolysis yielded ornithine as the only amino acid and, on dansylation studied, yielded didansyl ornithine. The meta...

journal_title：Clinical biochemistry

authors： Gordon BA,Gatfield PD,Taller E

更新日期：1977-04-01 00:00:00

abstract：:Improving long-term management, life-quality and outcome of transplant recipients continues to be a challenge. The impact of highly chemoattractant proteins as chemokines on transplant outcome is undeniable. These immunoactive molecules are critical in a wide variety of physiological and pathological processes, such a...

journal_title：Clinical biochemistry

authors： Crescioli C

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND:The p53 gene is an established tumor suppressor and an inducer of apoptosis. We here attempt to determine whether the putative anticarcinogenic properties attributed to red wine and its polyphenolic constituents depend, at least in part, upon their ability to modulate p53 expression in cancer cells. METHODS...

journal_title：Clinical biochemistry

authors： Soleas GJ,Goldberg DM,Grass L,Levesque M,Diamandis EP

更新日期：2001-07-01 00:00:00

abstract：OBJECTIVE:To confirm that the naproxen metabolite O-desmethylnaproxen interferes with the Jendrassik and Grof method for total bilirubin and was a possible cause of spurious hyperbilirubinemia in a case of naproxen overdose. DESIGN AND METHODS:Plasma was spiked with naproxen or O-desmethylnaproxen before total and dir...

journal_title：Clinical biochemistry

authors： Al Riyami N,Zimmerman AC,Rosenberg FM,Holmes DT

更新日期：2009-01-01 00:00:00

abstract：OBJECTIVES:Oxidative stress plays a role in the pathogenesis in patients with HCV infection. The objective of this study was to evaluate oxidant and antioxidant biomarkers in patients with HCV. DESIGN AND METHODS:Serum malonaldehyde (MDA) and nitric oxide (NO) levels and the activities of myeloperoxidase (MPO), aryles...

journal_title：Clinical biochemistry

authors： Ali EM,Shehata HH,Ali-Labib R,Esmail Zahra LM

更新日期：2009-09-01 00:00:00

abstract：:Monitoring blood levels of Cyclosporine (CsA) has been the basis for adjusting individual dosage regimens in the clinic. Radioimmunoassays using polyclonal antisera reacted with CsA and some CsA metabolites, leading to overestimation when compared with high-performance liquid chromatographic measurements of CsA. Monoc...

journal_title：Clinical biochemistry

authors： Quesniaux VF

更新日期：1991-02-01 00:00:00