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The susceptibility of lipoprotein(a) to copper oxidation is correlated with the susceptibility of autologous low density lipoprotein to oxidation.

Abstract：

OBJECTIVES:Lipoprotein(a) [Lp(a)] can be oxidized by copper in vitro in a way comparable to low-density lipoprotein (LDL). We sought to determine whether the susceptibility of Lp(a) to oxidation is correlated with the susceptibility of autologous heterogeneous LDL, with apolipoprotein(a) [apo(a)] molecular size, or with both factors. DESIGN AND METHODS:We examined shifts in electrophoretic mobility of Lp(a) and LDL caused by copper oxidation in plasma samples from 81 healthy men. The effect of copper oxidation on different-sized apo(a) was also evaluated. RESULTS:There was a close correlation between the relative electrophoretic mobilities of oxidized Lp(a) and oxidized LDL in subjects, especially with small-sized apo(a) (n = 25, r = 0.72, p < 0.0001). Oxidative processes in Lp(a) resulted in the degradation of large-, but not small-sized apo(a). CONCLUSIONS:The susceptibility of Lp(a) to oxidation is correlated with that of autologous LDL. Large-sized apo(a) may be involved in the Lp(a) oxidation.

journal_name

Clin Biochem

journal_title

Clinical biochemistry

authors

Nakajima K,Yamashita T,Kusuhara M,Yonemura A,Ito T,Higashi K,Ayaori M,Ohmori R,Nakamura H,Ohsuzu F

doi

10.1016/s0009-9120(02)00438-1

subject

Has Abstract

pub_date

2003-03-01 00:00:00

pages

113-20

issue

2

eissn

0009-9120

issn

1873-2933

pii

S0009912002004381

journal_volume

36

pub_type

杂志文章

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