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Serum galectin-3 levels in patients with nonalcoholic fatty liver disease.

Abstract：

OBJECTIVES:Galectin-3 might serve as a biomarker of human metabolic alterations. We measured serum levels of galectin-3 in patients with nonalcoholic fatty liver disease (NAFLD) and examined their association with clinical and histological phenotypes. DESIGN AND METHODS:Serum levels of galectin-3 were assayed in 71 patients with biopsy-proven NAFLD and 39 controls. RESULTS:Serum galectin-3 levels did not differ in patients with NAFLD (median 4.1 ng/mL; interquartile range: 1.5-5.5 ng/mL) compared with healthy controls (median 3.1 ng/mL; interquartile range: 0.8-7.5 ng/mL, P=0.93). Among patients with NAFLD, however, serum galectin-3 levels correlated significantly with BMI (r=0.267, P<0.05). This association persisted after adjustment for potential confounders (β=0.30; t=2.11, P<0.05). CONCLUSIONS:Although galectin-3 was modestly associated with BMI, our results do not support the hypothesis that levels of this molecule are altered in patients with NAFLD.

journal_name

Clin Biochem

journal_title

Clinical biochemistry

authors

Yilmaz Y,Eren F,Kurt R,Yonal O,Polat Z,Senates E,Bacha M,Imeryuz N

doi

10.1016/j.clinbiochem.2011.05.015

subject

Has Abstract

pub_date

2011-08-01 00:00:00

pages

955-8

issue

12

eissn

0009-9120

issn

1873-2933

pii

S0009-9120(11)00366-3

journal_volume

44

pub_type

杂志文章

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