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Inverse correlation of ribosomal protein S27A and multifunctional protein YB-1 in hepatocellular carcinoma.

Abstract：

OBJECTIVE:The detection of possible correlation between ribosomal protein RPS27A and multifunctional YB-1 expression in hepatocellular carcinoma (HCC). DESIGN AND METHODS:Tissue microarray slides containing totally 80 cores with 19 tissues of HCC, 1 tissue of hepatocholangiocarcinoma, 10 tissues of liver cirrhosis and 10 normal liver tissues in duplicates were analyzed for expression of RPS27A and YB-1 by immunohistochemistry. RESULTS:Among each of 10 LC and normal liver tissues all (100%) showed RPS27A positive expression but only 11 out of 19 HCC tissues (57.89%) showed RPS27A positive expression with significant difference compared (P<0.05) with both LC and normal tissues. We found positive expression of YB-1 in 17 tissues out of 19 HCC tissues (89.47%) but only 4 tissues out of each 10 LC as well as normal liver tissues showed positive expression with significant (P<0.01) difference compared to HCC tissues. A statistically significant inverse weak correlation (rho=-0.293) between YB-1 expression and RPS27A expression was found. CONCLUSION:The present investigation concludes that the ribosomal protein RPS27A was down-regulated in viral induced HCC patients. RPS27A expression was found to have a weak inverse correlation with overexpression of multifunctional protein YB-1 in HCC tissues. This study opens up a new window for YB-1-RPS27A axis in HCC.

journal_name

Clin Biochem

journal_title

Clinical biochemistry

authors

Gunasekaran VP,Ganeshan M

doi

10.1016/j.clinbiochem.2014.05.004

subject

Has Abstract

pub_date

2014-09-01 00:00:00

pages

1262-4

issue

13-14

eissn

0009-9120

issn

1873-2933

pii

S0009-9120(14)00224-0

journal_volume

47

pub_type

杂志文章

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