当前位置： SCI文献检索 > CLINICAL BIOCHEMISTRY期刊下所有文献 > Interaction of common sequence variants and selected risk factors in determination of HDL cholesterol levels.

Interaction of common sequence variants and selected risk factors in determination of HDL cholesterol levels.

Abstract：

OBJECTIVES:The aim of our study was to assess the association of common sequence variants, and selected interactions, with HDL-c plasma levels. DESIGN AND METHODS:We analysed 743 individuals (340 men and 403 women) with high mean triglyceride and LDL-c levels. The association of five polymorphic sites (ABCA1 g.1051G>A, APOA1 g.-75G>A, CETP g.-629C>A, HNF1A g.102A>C, and LIPG g.584C>T), apoE isoforms and selected interactions with HDL-c levels were evaluated using linear regression models. RESULTS:After adjusting for triglycerides, sex, and BMI the only genotype with a statistically significant effect on HDL-c levels (p-value=0.004) was the CETP promoter variant. Further, linear regression model with interactions included indicated possible interplay between APOA1 genotype and menopause (p-value=0.002) and ABCA1 and APOE isoforms (p-value=0.017) on HDL-c plasma concentration. CONCLUSIONS:Our study indicated that not only the CETP variant but also apoE isoforms and menopause could operate as potent modulators of HDL-c concentrations.

journal_name

Clin Biochem

journal_title

Clinical biochemistry

authors

Katerina H,Michaela S,Michal V,Helena S,Jana Z,Jaroslav H,Richard C

doi

10.1016/j.clinbiochem.2010.04.001

subject

Has Abstract

pub_date

2010-06-01 00:00:00

pages

754-8

issue

9

eissn

0009-9120

issn

1873-2933

pii

S0009-9120(10)00133-5

journal_volume

43

pub_type

杂志文章

相关文献

CLINICAL BIOCHEMISTRY文献大全
  • Do platelet apoptosis, activation, aggregation, lipid peroxidation and platelet-leukocyte aggregate formation occur simultaneously in hyperlipidemia?

    abstract：OBJECTIVES:The circulating lipoproteins may cause some abnormalities in platelet composition and function in hypercholesterolemia. The aim of this study was to investigate whether platelet apoptosis, platelet activation, platelet aggregation, platelet-leukocyte aggregate (PLA) formation and lipid peroxidation occur sim...

    journal_title：Clinical biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.clinbiochem.2005.09.005

    authors： Sener A,Ozsavci D,Oba R,Demirel GY,Uras F,Yardimci KT

    更新日期：2005-12-01 00:00:00

  • Mitochondrial dysfunction in skin biopsies and blood mononuclear cells from two cases of fibromyalgia patients.

    abstract：OBJECTIVES:Coenzyme Q(10) (CoQ(10)) is an essential electron carrier in the mitochondrial respiratory chain and a strong antioxidant. Signs associated with skin alteration and mitochondrial dysfunction have been observed in patients with fibromyalgia (FM). The aim of this study was to analyze CoQ(10) levels, mitochondr...

    journal_title：Clinical biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.clinbiochem.2010.06.013

    authors： Cordero MD,Moreno-Fernández AM,Carmona-López MI,Sánchez-Alcázar JA,Rodríguez AF,Navas P,de Miguel M

    更新日期：2010-09-01 00:00:00

  • Performance evaluation of four 25-hydroxyvitamin D assays to measure 25-hydroxyvitamin D2.

    abstract：OBJECTIVES:The ability of current immunoassays to accurately measure equimolar amounts of 25(OH)D2 and 25(OH)D3 has been recently questioned. This study determined serum 25(OH)D2, 25(OH)D3 and total serum 25(OH)D concentrations in healthy vitamin D2-supplemented subjects by isotope dilution liquid chromatography mass s...

    journal_title：Clinical biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.clinbiochem.2015.05.021

    authors： Freeman J,Wilson K,Spears R,Shalhoub V,Sibley P

    更新日期：2015-11-01 00:00:00

  • The possibility of determining N-acetyl-beta-D-glucosaminidase isoenzymes under alkaline conditions.

    abstract：OBJECTIVES:To have a reliable diagnostic test, the influence of urine pH on the determination of the total activity of N-acetyl-beta-D-glucosaminidase (NAG) and NAG isoenzyme activities was studied. DESIGN AND METHODS:After ultrafiltration and dialysis of the acidic and alkaline urines, the B, A, and A2 forms of NAG w...

    journal_title：Clinical biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.clinbiochem.2005.01.002

    authors： Mandić LM,Aćimović JM,Jovanović VB

    更新日期：2005-04-01 00:00:00

  • In vivo probes: problems and perspectives.

    abstract：:Devices constructed for potential use as invasive bioprobes incorporate a selective receiving site for molecular or ionic recognition, and a transducer which is capable of translating a perturbation of physical chemistry of the determinant-site reaction (interaction) into a usable signal. Four types are envisioned--im...

    journal_title：Clinical biochemistry

    pub_type： 杂志文章,评审

    doi：10.1016/s0009-9120(86)80037-6

    authors： Thompson M,Vandenberg ET

    更新日期：1986-10-01 00:00:00

  • Haplotypes in the UGT1A1 gene and their role as genetic determinants of bilirubin concentration in healthy German volunteers.

    abstract：BACKGROUND:Genetic variations of UDP-glucuronyltransferase 1A1 (UGT1A1) influence the concentration of serum bilirubin. We investigated the association of four common polymorphisms including UGT1A1-53(TA)(n), and common haplotypes of the UGT1A1 gene with bilirubin levels in 218 Caucasian volunteers. METHODS:Total bili...

    journal_title：Clinical biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.clinbiochem.2009.08.011

    authors： Borucki K,Weikert C,Fisher E,Jakubiczka S,Luley C,Westphal S,Dierkes J

    更新日期：2009-11-01 00:00:00

  • Antioxidative enzymes and increased oxidative stress in depressive women.

    abstract：OBJECTIVES:To investigate the activities of the main antioxidative enzymes and oxidative stress in women with depressive disorder (DD). METHODS:In 35 drug-naive women with DD and 35 age matched healthy women enzymes superoxide dismutase (CuZnSOD), catalase (CAT), glutathione peroxidase (GPX1), glutathione reductase (G...

    journal_title：Clinical biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.clinbiochem.2009.06.006

    authors： Kodydková J,Vávrová L,Zeman M,Jirák R,Macásek J,Stanková B,Tvrzická E,Zák A

    更新日期：2009-09-01 00:00:00

  • Determination of beta4-galactosyltransferase-7 activity using high-performance liquid chromatography-electrospray ionization tandem mass spectrometry.

    abstract：OBJECTIVES:Patients with Ehlers-Danlos syndrome were described to contain reduced activities of beta4-galactosyltransferase-7 (beta4Gal-T7). Therefore, measurement of beta4Gal-T7 activity can help to characterize defects in proteoglycan biosynthesis in patients with connective tissue diseases. DESIGN AND METHODS:We de...

    journal_title：Clinical biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.clinbiochem.2008.12.009

    authors： Kuhn J,Kleesiek K,Götting C

    更新日期：2009-04-01 00:00:00

  • Hyaluronic acid as a non-invasive biomarker of liver fibrosis.

    abstract：UNLABELLED:Chronic liver diseases may cause inflammation and progressive scarring, over time leading to irreversible hepatic damage (cirrhosis). As a result, the need to assess and closely monitor individuals for risk factors of components of matrix deposition and degradation, as well as the severity of the fibrosis us...

    journal_title：Clinical biochemistry

    pub_type： 杂志文章,评审

    doi：10.1016/j.clinbiochem.2015.07.019

    authors： Neuman MG,Cohen LB,Nanau RM

    更新日期：2016-02-01 00:00:00

  • Measurement of placental lactogen in undiluted serum by radioimmunoassay utilizing polyethylene glycol as separating agent. Values obtained in pregnancy.

    abstract：:We describe a simple and reliable radioimmunoassay (RIA) method for the measurement of human placental lactogen (hPL) in undiluted serum. Standard curves, in serum, cover the range of 0.015 to 1 mlU/L for early pregnancy monitoring (7 to 15 weeks, referred to as Procedure I), and 0.531 to 17 mIU/L for mid and late pre...

    journal_title：Clinical biochemistry

    pub_type： 杂志文章

    doi：10.1016/s0009-9120(82)90753-6

    authors： Englebienne P,Doyen G,Dervaux R,Billemont JP

    更新日期：1982-04-01 00:00:00

  • Association of serum adiponectin with diabetic microvascular complications among south Indian type 2 diabetic subjects - (CURES-133).

    abstract：OBJECTIVES:To assess the association of serum adiponectin and microvascular complications of diabetes in an urban south Indian type 2 diabetic population. DESIGN AND METHODS:Diabetic subjects [n=487] were included from Chennai Urban Rural Epidemiology Study (CURES). Four-field stereo retinal color photography was done...

    journal_title：Clinical biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.clinbiochem.2014.10.009

    authors： Pradeepa R,Surendar J,Indulekha K,Chella S,Anjana RM,Mohan V

    更新日期：2015-01-01 00:00:00

  • Relation between iron content of serum ferritin and clinical status factors extracted by factor analysis in patients with hyperferritinemia.

    abstract：OBJECTIVES:The aims of this study were to develop a new technique for determination of iron content of serum ferritin (ICF, micromol Fe/mg protein) and to investigate relations between ICF and clinical status in patients with hyperferritinemia. METHODS:ICF values were determined by a combination of immunoprecipitation...

    journal_title：Clinical biochemistry

    pub_type： 杂志文章

    doi：10.1016/s0009-9120(02)00380-6

    authors： Yamanishi H,Iyama S,Yamaguchi Y,Kanakura Y,Iwatani Y

    更新日期：2002-10-01 00:00:00

  • Comparison of plasma ammonia results from seven different automated platforms in use throughout Central Australia.

    abstract：INTRODUCTION:The clinical catchment area for the Metabolic service at the Women's and Children's Hospital in Adelaide, South Australia, covers nearly 2.5millionkm2. Care of children with metabolic disorders in these remote areas is assisted from Adelaide, and at times, using plasma ammonia results from laboratories up ...

    journal_title：Clinical biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.clinbiochem.2016.11.025

    authors： Markus C,Metz M

    更新日期：2017-04-01 00:00:00

  • Type 1-prophospholipase A2 propeptide immunoreactivity is released from activated granulocytes.

    abstract：OBJECTIVE:To establish a ELISA assay to measure release of type 1-phospholipase A2 propeptide from activated granulocytes. Human type 1-prophospholipase A2 (1-proPLA2) is biosynthesized and stored as inactive zymogen. Activation involves tryptic-like cleavage at the N-terminus, with equimolar release of the heptapeptid...

    journal_title：Clinical biochemistry

    pub_type： 杂志文章

    doi：10.1016/0009-9120(94)00068-7

    authors： Rae D,Sumar N,Beechey-Newman N,Gudgeon M,Hermon-Taylor J

    更新日期：1995-02-01 00:00:00

  • A simpler diagnostic formula for screening nonalcoholic fatty liver disease.

    abstract：OBJECTIVE:To increase the accuracy of non-invasive diagnosis of nonalcoholic fatty liver disease (NAFLD), clinical and laboratory NAFLD indicators were integrated into a diagnostic formula. METHODS:A total of 141 patients with clinically diagnosed NAFLD and 30 healthy controls were enrolled. We collected case history,...

    journal_title：Clinical biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.clinbiochem.2018.11.011

    authors： Feng G,He N,Zhou YF,Li XP,Niu C,Liu ML,Zhang KL,Li Y,Li YM,Zheng MH,Mi M

    更新日期：2019-02-01 00:00:00

  • Association of glutathione-S-transferase gene polymorphism and lipoprotein subclasses in hemodialysis patients.

    abstract：OBJECTIVES:End-stage renal disease (ESRD) is characterized by profound dyslipidemia and enhanced oxidative stress. The patients also show evidence of exhausted and/or deficient anti-oxidative defense enzymes, one of them being glutathione-S-transferase (GST). This study investigates relationship between GST gene polymo...

    journal_title：Clinical biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.clinbiochem.2013.11.011

    authors： Vekic J,Zeljkovic A,Jelic-Ivanovic Z,Damjanovic T,Suvakov S,Matic M,Savic-Radojevic A,Simic T,Spasojevic-Kalimanovska V,Gojkovic T,Spasic S,Dimkovic N

    更新日期：2014-04-01 00:00:00

  • Polymorphisms of TGFβ-1 and TGFBR2 in relation to coronary artery disease in a Chinese population.

    abstract：BACKGROUND AND AIM:TGF-β1 has been previously reported to be involved in the pathogenesis of atherosclerosis. The aim of the present study was to assess whether functional gene polymorphisms of TGF-β1 and its key receptor TGF-β receptor type II (TGFBR2) contribute as risk factors to the onset and severity of atheroscle...

    journal_title：Clinical biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.clinbiochem.2016.05.022

    authors： Yang M,Zhu M,Tang L,Zhu H,Lu Y,Xu B,Jiang J,Chen X

    更新日期：2016-08-01 00:00:00

  • In vitro and in vivo cell-capture strategies using cardiac stent technology - A review.

    abstract：:Stenosis is a symptom of coronary artery disease (CAD), and is caused by narrowing of arteries in the heart. Over the last several decades, medical implants such as cardiac stents have been developed to counter stenosis. Upon implantation of a stent to open up a restricted artery, narrowing of the artery can reoccur (...

    journal_title：Clinical biochemistry

    pub_type： 杂志文章,评审

    doi：10.1016/j.clinbiochem.2015.09.012

    authors： Ravindranath RR,Romaschin A,Thompson M

    更新日期：2016-01-01 00:00:00

  • The first study of galactose-1-phosphate uridyl transferase mutations in Iranian galactosemia patients.

    abstract：OBJECTIVES:Classical galactosemia (McKusick 230400) is an autosomal recessive disorder caused by mutations in the galactose-1-phosphate uridyl transferase (GALT;EC 2.7.7.10) gene. DESIGN AND METHODS:In the present study, we report molecular analysis of 14 unrelated Iranian galactosemia children with reduced or without...

    journal_title：Clinical biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.clinbiochem.2006.04.020

    authors： Mirzajani F,Mirfakhraie R,Nabati F,Tabatabaei NN,Talachian E,Houshmand M

    更新日期：2006-07-01 00:00:00

  • Impact of long distance rowing on biological health: A pilot study.

    abstract：OBJECTIVES:To determine the impact of long distance rowing (160km, nonstop) on standard biological parameters and to study the relation between inflammation, myocardial necrosis, lipid profile, heart rate and energy expenditure. METHODS:Electrolytes, lipid profile, C-reactive protein (CRP), interleukin-6 (IL-6), tumor...

    journal_title：Clinical biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.clinbiochem.2017.11.018

    authors： Frias MA,Virzi J,Golaz O,Gencer B,Mach F,Vuilleumier N

    更新日期：2018-02-01 00:00:00

  • Comparative performance of two methods that assess the quality of international normalized ratio measures.

    abstract：OBJECTIVES:Two methods, Petersen's error grid analysis and Shermock's method to detect clinically important differences, were recently developed to advance the assessment of analytic performance of point-of-care INR devices. Both methods predict when alternate INR measures lead to different clinical decisions. Our goal...

    journal_title：Clinical biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.clinbiochem.2012.01.032

    authors： Shermock KM,Tandon S,Sorgen PJ,Lavallee DC,Clarke W,Streiff MB

    更新日期：2012-05-01 00:00:00

  • Heparin affects matrix metalloproteinases and tissue inhibitors of metalloproteinases circulating in peripheral blood.

    abstract：OBJECTIVES:Blood sampling/handling alters matrix metalloproteinases (MMP) and tissue inhibitors of metalloproteinases (TIMP) expression. The aim of this study is to evaluate the effects of high molecular weight heparin on MMP and TIMP expression in blood. DESIGN AND METHODS:We analyzed by gelatin zymography and ELISA ...

    journal_title：Clinical biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.clinbiochem.2008.09.104

    authors： Mannello F,Jung K,Tonti GA,Canestrari F

    更新日期：2008-12-01 00:00:00

  • Evaluation of a mini-column chromatographic procedure for the measurement of hemoglobin A1c.

    abstract：:An ion-exchange chromatographic procedure is described which facilitates the determination of beta-chain aminoterminal modified glycated hemoglobin. The procedure includes an erythrocyte lysis reagent which eliminates the labile aldimine component (pre-A1c) and a two-stage elution step which separates HbA, 1a + b from...

    journal_title：Clinical biochemistry

    pub_type： 杂志文章

    doi：10.1016/s0009-9120(85)80020-5

    authors： Jaynes PK,Willis MC,Chou PP

    更新日期：1985-02-01 00:00:00

  • Monoclonal antibody technology for cyclosporine monitoring.

    abstract：:Monitoring blood levels of Cyclosporine (CsA) has been the basis for adjusting individual dosage regimens in the clinic. Radioimmunoassays using polyclonal antisera reacted with CsA and some CsA metabolites, leading to overestimation when compared with high-performance liquid chromatographic measurements of CsA. Monoc...

    journal_title：Clinical biochemistry

    pub_type： 杂志文章,评审

    doi：10.1016/0009-9120(91)90147-7

    authors： Quesniaux VF

    更新日期：1991-02-01 00:00:00

  • Urinary kidney injury molecule-1 and neutrophil gelatinase-associated lipocalin as indicators of tubular damage in normoalbuminuric patients with type 2 diabetes.

    abstract：OBJECTIVES:Renal dysfunction has been reported in normoalbuminuric patients, demonstrating the necessity to improve the diagnostic and prognostic tools for diabetic kidney disease (DKD) investigation. Therefore, the aim of this study was to investigate whether the urinary levels of neutrophil gelatinase-associated lipo...

    journal_title：Clinical biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.clinbiochem.2015.10.016

    authors： de Carvalho JA,Tatsch E,Hausen BS,Bollick YS,Moretto MB,Duarte T,Duarte MM,Londero SW,Premaor MO,Comim FV,Delanghe JR,Moresco RN

    更新日期：2016-02-01 00:00:00

  • Association between FSH, E1, and E2 levels in urine and serum in premenopausal and postmenopausal women.

    abstract：OBJECTIVE:We aimed to establish correlations for the levels of follicle-stimulating hormone (FSH), estrone (E1) and estradiol (E2) between urine and serum in premenopausal and postmenopausal women using immunoassays. METHODS:In this study of 92 women (61 postmenopausal, 31 premenopausal), both urine and blood specimen...

    journal_title：Clinical biochemistry

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.clinbiochem.2019.08.009

    authors： Onizuka Y,Nagai K,Ideno Y,Kitahara Y,Iwase A,Yasui T,Nakajima-Shimada J,Hayashi K

    更新日期：2019-11-01 00:00:00

  • An insulin-dose error assessment grid: A new tool to evaluate glucose meter performance.

    abstract：OBJECTIVE:To develop a tool to assess the clinical accuracy of glucose meter performance using an insulin dosing protocol to assess the frequency and extent of error in insulin dose categories. METHODS:Retrospective comparison of 1815 glucose meter and central laboratory glucose results obtained from 1698 critically i...

    journal_title：Clinical biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.clinbiochem.2019.06.001

    authors： Lyon ME,Lyon OAS,Tran NK,DuBois JA,Lyon AW

    更新日期：2019-08-01 00:00:00

  • Disinfectant wipes containing hydrogen peroxide induce overestimation of glucose results obtained with Lifescan SureStep Flexx® glucose meter.

    abstract：OBJECTIVES:Investigate the interference of Virox® disinfectant wipes containing hydrogen peroxide with Lifescan SureStep Flexx® glucose meter results. DESIGN AND METHODS:Glucose measurements of control and whole blood samples were performed before and after cleaning with Virox® wipes to reveal the kinetics of this int...

    journal_title：Clinical biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.clinbiochem.2010.09.012

    authors： Desmeules P,Ethier J,Allard P

    更新日期：2010-12-01 00:00:00

  • Spurious hyperbilirubinemia caused by naproxen.

    abstract：OBJECTIVE:To confirm that the naproxen metabolite O-desmethylnaproxen interferes with the Jendrassik and Grof method for total bilirubin and was a possible cause of spurious hyperbilirubinemia in a case of naproxen overdose. DESIGN AND METHODS:Plasma was spiked with naproxen or O-desmethylnaproxen before total and dir...

    journal_title：Clinical biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.clinbiochem.2008.09.119

    authors： Al Riyami N,Zimmerman AC,Rosenberg FM,Holmes DT

    更新日期：2009-01-01 00:00:00

  • Plasma circular RNA panel acts as a novel diagnostic biomarker for colorectal cancer.

    abstract：BACKGROUND:Colorectal cancer (CRC) is one of the most common cancers worldwide, and emerging lines of evidence have implicated circular RNAs (circRNAs), a novel class of endogenous noncoding RNAs, in CRC development. However, whether plasma circRNAs might be novel diagnostic biomarkers for CRC remains unclear. METHODS...

    journal_title：Clinical biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.clinbiochem.2019.10.012

    authors： Lin J,Cai D,Li W,Yu T,Mao H,Jiang S,Xiao B

    更新日期：2019-12-01 00:00:00