Abstract:
OBJECTIVES:This study explored the relationship between oxidative stress biomarkers and stability of carotid plaque. We decided to analyze the broad range of parameters describing oxidative stress in patients with carotid stenosis. DESIGN AND METHODS:124 consecutive patients undergoing carotid endarterectomy were enrolled in the study group. The control group consisted of 49 patients without symptoms of atherosclerosis. The stability of carotid plaques was assessed using GSM (gray-scale median) scoring system and the study group was divided into three subgroups according to echogenicity of the plaque. The following parameters of oxidative stress/DNA damage were analyzed: i) urinary excretion of the products of oxidative DNA damage repair; ii) the background level of 8-oxo-7,8-dihydro-2'-deoxyguanosine in leukocytes' DNA and in atherosclerotic plaques; and iii) the concentrations of antioxidant vitamins, uric acid and C-reactive protein in plasma. RESULTS:Oxidative stress (described by redox status) was higher in the patient group than in the control group. There is a correlation between oxidative stress of the patients and stability of the plaque, echolucent plaques (GSM<25) being associated with the highest antioxidant level and lowest excretion of DNA repair markers. CONCLUSIONS:The plaque formation/morphology may depend on local environment and is independent of oxidative stress/inflammation observed on the level of the whole body.
journal_name
Clin Biochemjournal_title
Clinical biochemistryauthors
Rozalski R,Migdalski A,Gackowski D,Guz J,Siomek A,Foksinski M,Szpila A,Zarakowska E,Majer M,Jawien A,Olinski Rdoi
10.1016/j.clinbiochem.2013.05.057subject
Has Abstractpub_date
2013-08-01 00:00:00pages
1030-1035issue
12eissn
0009-9120issn
1873-2933pii
S0009-9120(13)00253-1journal_volume
46pub_type
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journal_title:Clinical biochemistry
pub_type: 杂志文章
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更新日期:2014-04-01 00:00:00
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更新日期:2012-12-01 00:00:00
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更新日期:2018-09-01 00:00:00
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更新日期:1992-08-01 00:00:00
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doi:10.1016/j.clinbiochem.2009.09.019
更新日期:2010-01-01 00:00:00
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更新日期:2006-01-01 00:00:00
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journal_title:Clinical biochemistry
pub_type: 杂志文章
doi:10.1016/s0009-9120(96)00159-2
更新日期:1997-03-01 00:00:00
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journal_title:Clinical biochemistry
pub_type: 杂志文章,多中心研究
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更新日期:1993-02-01 00:00:00
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更新日期:1998-11-01 00:00:00
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更新日期:2020-03-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2003-09-01 00:00:00
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更新日期:2018-11-01 00:00:00
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doi:10.1016/j.clinbiochem.2016.10.005
更新日期:2017-01-01 00:00:00
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doi:10.1016/s0009-9120(78)90434-4
更新日期:1978-08-01 00:00:00
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journal_title:Clinical biochemistry
pub_type: 杂志文章,评审
doi:10.1016/0009-9120(88)90001-x
更新日期:1988-06-01 00:00:00
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journal_title:Clinical biochemistry
pub_type: 杂志文章
doi:10.1016/j.clinbiochem.2005.08.004
更新日期:2005-11-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/s0009-9120(97)00074-x
更新日期:1997-08-01 00:00:00
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更新日期:2005-08-01 00:00:00
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journal_title:Clinical biochemistry
pub_type: 杂志文章
doi:10.1016/j.clinbiochem.2006.11.004
更新日期:2007-03-01 00:00:00
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journal_title:Clinical biochemistry
pub_type: 杂志文章
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更新日期:2008-02-01 00:00:00
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journal_title:Clinical biochemistry
pub_type: 杂志文章
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更新日期:1978-04-01 00:00:00
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更新日期:2020-12-01 00:00:00
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journal_title:Clinical biochemistry
pub_type: 杂志文章
doi:10.1016/j.clinbiochem.2008.04.008
更新日期:2008-07-01 00:00:00
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journal_title:Clinical biochemistry
pub_type: 杂志文章
doi:10.1016/j.clinbiochem.2013.11.019
更新日期:2014-04-01 00:00:00
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journal_title:Clinical biochemistry
pub_type: 杂志文章
doi:10.1016/j.clinbiochem.2007.03.021
更新日期:2007-07-01 00:00:00
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pub_type: 杂志文章
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更新日期:2000-03-01 00:00:00
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pub_type: 杂志文章
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更新日期:2011-06-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1016/s0009-9120(97)00113-6
更新日期:1997-12-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.clinbiochem.2007.01.010
更新日期:2007-06-01 00:00:00