Cox proportional hazard model analysis of survival in end-stage renal disease patients with small-sized high-density lipoprotein particles.

Abstract:

OBJECTIVE:Dyslipidemia is commonly seen in patients with end-stage renal disease (ESRD). This prospective study investigates whether small-sized high-density lipoprotein (HDL) particles alone or in combination with high sensitivity C-reactive protein (hsCRP) are independent determinants of ESRD mortality. DESIGN AND METHODS:We performed 36 months follow-up study in 122 haemodialysis (HD) patients. HDL size and subclass distribution were determined by gradient gel electrophoresis. Baseline characteristics of the patients were evaluated for the prediction of mortality. RESULTS:Cox regressions analysis showed that patients with small-sized HDL particles had 2.8-fold higher risk of lethal outcome (P<0.05). Concomitant presence of small-sized HDL particles and increased hsCRP concentration were significantly associated with reduced survival rate (HR=3.907; P<0.05). Observed relationships persisted after adjustment for serum lipid and lipoprotein concentrations. CONCLUSIONS:Our results indicate that small-sized HDL particles alone and combined with elevated hsCRP concentrations are independent predictors of reduced survival in HD patients.

journal_name

Clin Biochem

journal_title

Clinical biochemistry

authors

Vekic J,Zeljkovic A,Bogavac-Stanojevic N,Jelic-Ivanovic Z,Spasojevic-Kalimanovska V,Simic-Ogrizovic S,Dopsaj V,Spasic S

doi

10.1016/j.clinbiochem.2011.02.002

subject

Has Abstract

pub_date

2011-06-01 00:00:00

pages

635-41

issue

8-9

eissn

0009-9120

issn

1873-2933

pii

S0009-9120(11)00064-6

journal_volume

44

pub_type

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