Cox proportional hazard model analysis of survival in end-stage renal disease patients with small-sized high-density lipoprotein particles.


OBJECTIVE:Dyslipidemia is commonly seen in patients with end-stage renal disease (ESRD). This prospective study investigates whether small-sized high-density lipoprotein (HDL) particles alone or in combination with high sensitivity C-reactive protein (hsCRP) are independent determinants of ESRD mortality. DESIGN AND METHODS:We performed 36 months follow-up study in 122 haemodialysis (HD) patients. HDL size and subclass distribution were determined by gradient gel electrophoresis. Baseline characteristics of the patients were evaluated for the prediction of mortality. RESULTS:Cox regressions analysis showed that patients with small-sized HDL particles had 2.8-fold higher risk of lethal outcome (P<0.05). Concomitant presence of small-sized HDL particles and increased hsCRP concentration were significantly associated with reduced survival rate (HR=3.907; P<0.05). Observed relationships persisted after adjustment for serum lipid and lipoprotein concentrations. CONCLUSIONS:Our results indicate that small-sized HDL particles alone and combined with elevated hsCRP concentrations are independent predictors of reduced survival in HD patients.


Clin Biochem


Clinical biochemistry


Vekic J,Zeljkovic A,Bogavac-Stanojevic N,Jelic-Ivanovic Z,Spasojevic-Kalimanovska V,Simic-Ogrizovic S,Dopsaj V,Spasic S




Has Abstract


2011-06-01 00:00:00














  • Glucose-6-phosphate dehydrogenase enzyme stability in filter paper dried blood spots.

    abstract:OBJECTIVE:Prior to initial distribution of Glucose-6-phosphate dehydrogenase (G6PD) proficiency testing (PT) materials, we evaluated G6PD enzyme stability in dried blood spots (DBS) under various temperature and humidity environments to develop storage and usage guidelines for our new materials. DESIGN & METHODS:We pr...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Flores SR,Hall EM,De Jesús VR

    更新日期:2017-10-01 00:00:00

  • The use of proteomics for the assessment of clinical samples in research.

    abstract::Proteomics, the analysis of expressed proteins, has been an important developing area of research for the past two decades [Anderson, NG, Anderson, NL. Twenty years of two-dimensional electrophoresis: past, present and future. Electrophoresis 1996;17:443-453]. Advances in technology have led to a rapid increase in app...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章,评审


    authors: Aldred S,Grant MM,Griffiths HR

    更新日期:2004-11-01 00:00:00

  • An insulin-dose error assessment grid: A new tool to evaluate glucose meter performance.

    abstract:OBJECTIVE:To develop a tool to assess the clinical accuracy of glucose meter performance using an insulin dosing protocol to assess the frequency and extent of error in insulin dose categories. METHODS:Retrospective comparison of 1815 glucose meter and central laboratory glucose results obtained from 1698 critically i...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Lyon ME,Lyon OAS,Tran NK,DuBois JA,Lyon AW

    更新日期:2019-08-01 00:00:00

  • Plasma vaspin concentrations are decreased in acute coronary syndrome, but unchanged in patients without coronary lesions.

    abstract:OBJECTIVE:Previous studies suggested that decreased serum vaspin levels were associated with coronary artery disease (CAD). The present study aimed to investigate the association between plasma vaspin levels and different states of CAD. DESIGN AND METHODS:A total of 162 patients with coronary angiography (CAG) proved ...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Zhang B,Peng W,Li H,Lu Y,Zhuang J,Wang K,Su Y,Xu Y

    更新日期:2013-10-01 00:00:00

  • Immunoglobulin A subclass distribution in serum from patients with the acquired immunodeficiency syndrome.

    abstract::Immunoglobulin levels are elevated in the acquired immune deficiency syndrome (AIDS) and one class, IgA, has been suggested as a marker of disease progression. IgA is composed of two subclasses, IgA1 and IgA2; circulating IgA1 is roughly 85% of the total in healthy individuals. We have attempted to determine if the su...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Cassulis P,Farhangfar R,DeBari VA

    更新日期:1991-06-01 00:00:00

  • Is the turbidimetric immunoassay of haptoglobin phenotype-dependent?

    abstract::Comparison of the turbidimetric immunoassay of haptoglobin with a reference method (the RID technique with appropriate correction for phenotype) clearly showed the turbidimetric assay to be phenotype-dependent. Correction factors for the three main phenotypes were calculated and reference values determined. The observ...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: van Rijn HJ,van der Wilt W,Stroes JW,Schrijver J

    更新日期:1987-08-01 00:00:00

  • Optimizing RNA extraction yield from whole blood for microarray gene expression analysis.

    abstract:OBJECTIVES:Microarray analysis of gene expression profiles of blood leukocytes has many potential clinical and research applications. DESIGN AND METHODS:We used the PAXgene Blood RNA System to prepare RNA from the whole blood of normal volunteers using two incubation times followed by gene expression profiling using t...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Wang J,Robinson JF,Khan HM,Carter DE,McKinney J,Miskie BA,Hegele RA

    更新日期:2004-09-01 00:00:00

  • Quantifying MMA by SLE LC-MS/MS: Unexpected challenges in assay development.

    abstract:OBJECTIVES:Analysis of serum/plasma methylmalonic acid (MMA) is important for the diagnosis and management of methylmalonic acidemia in pediatric populations. This work focuses on developing and validating a liquid chromatography tandem mass spectrometry (LC-MS/MS) method to monitor methylmalonic acidemia using a simpl...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Lo SY,Gordon C,Sadilkova K,Jack RM,Dickerson JA

    更新日期:2016-09-01 00:00:00

  • Circulating P-, L- and E-selectins in pseudoxanthoma elasticum patients.

    abstract:OBJECTIVES:Pseudoxanthoma elasticum (PXE) is a hereditary disorder predominantly affecting the skin, retina and vascular system. The aim of this study was to measure cell adhesion molecules in PXE patients. DESIGN AND METHODS:Soluble P-, E- and L-selectins were measured in 61 non-consanguineous PXE patients. The distr...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Götting C,Adam A,Szliska C,Kleesiek K

    更新日期:2008-04-01 00:00:00

  • Screening for Down syndrome during the first and second trimesters: impact of risk estimation parameters.

    abstract:OBJECTIVES:To evaluate impact of risk estimation parameters for screening for Down Syndrome during the first and second trimesters. METHODS:We prospectively examined for their performance in the prenatal prediction of trisomy 21, alphafetoprotein (AFP), unconjugated estriol (uE3), total human chorionic gonadotropin (h...

    journal_title:Clinical biochemistry

    pub_type: 临床试验,杂志文章


    authors: Forest JC,Massé J,Rousseau F,Moutquin JM,Brideau NA,Bélanger M

    更新日期:1995-08-01 00:00:00

  • Efficacy of simultaneous determination of bone alkaline phosphatase mass concentration in serum and urinary excretion of pyridinium cross-links for detection of bone metastases.

    abstract:OBJECTIVES:To examine the diagnostic validity of bone alkaline phosphatase (BAP) in serum (a marker of bone formation) and of urinary excretion of pyridinium cross-links (PYR) (a marker of bone resorption) for detection of bone metastases. DESIGN AND METHODS:Two heterogeneous immunoassays were employed for determinati...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Withold W,Georgescu G,Khakzad H,Vosberg H,Mueller-Gaertner HW,Reinauer H

    更新日期:1995-10-01 00:00:00

  • Simvastatin treatment reduces heat shock protein 60, 65, and 70 antibody titers in dyslipidemic patients: A randomized, double-blind, placebo-controlled, cross-over trial.

    abstract:OBJECTIVE:This study aimed to evaluate the effects of statin therapy on serum levels of antibodies to several specific heat shock proteins (HSPs) in dyslipidemic patients. DESIGN AND METHODS:Participants (n=102) were treated with simvastatin (40mg/day), or placebo in a randomized, double-blind, placebo-controlled, cro...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章,随机对照试验


    authors: Moohebati M,Bidmeshgi S,Azarpazhooh MR,Daloee MH,Ghayour-Mobarhan M,Tavallaie S,Amini M,Momenzadeh A,Sahebkar A,Paydar R,Rahsepar AA,Parizadeh SM,Akhlaghi S,Ferns GA

    更新日期:2011-02-01 00:00:00

  • Soluble urokinase-type plasminogen activator receptor forms in plasma as markers of atherosclerotic plaque vulnerability.

    abstract:OBJECTIVES:: To test if circulating forms of the soluble urokinase-type plasminogen activator receptor (suPAR) are potential biomarkers of plaque vulnerability. DESIGN AND METHODS:: Plasma concentrations of suPAR(I-III), suPAR(II-III) and uPAR(I) were measured by time-resolved fluorescence immunoassays in Caucasian pa...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Olson FJ,Thurison T,Ryndel M,Høyer-Hansen G,Fagerberg B

    更新日期:2010-01-01 00:00:00

  • Low basal levels of circulating adiponectin in patients undergoing coronary stenting predict in-stent restenosis, independently of basal levels of inflammatory markers: lipoprotein associated phospholipase A2, and myeloperoxidase.

    abstract:OBJECTIVE:The aim of this study was to find a pre-interventional marker with the capacity to predict in-stent restenosis (ISR). Considering the anti-atherosclerotic role of adiponectin (APO), an adipocytokine with anti-inflammatory, anti-proliferative, anti-oxidative and anti-thrombotic properties, low plasma levels of...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Moldoveanu E,Mut-Vitcu B,Tanaseanu GR,Marta DS,Manea G,Kosaka T,Vidulescu C,Tanaseanu C

    更新日期:2008-12-01 00:00:00

  • Association of serum adiponectin with diabetic microvascular complications among south Indian type 2 diabetic subjects - (CURES-133).

    abstract:OBJECTIVES:To assess the association of serum adiponectin and microvascular complications of diabetes in an urban south Indian type 2 diabetic population. DESIGN AND METHODS:Diabetic subjects [n=487] were included from Chennai Urban Rural Epidemiology Study (CURES). Four-field stereo retinal color photography was done...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Pradeepa R,Surendar J,Indulekha K,Chella S,Anjana RM,Mohan V

    更新日期:2015-01-01 00:00:00

  • Evaluation of the YSI 2300 glucose analyzer: algorithm-corrected results are accurate and specific.

    abstract:OBJECTIVES:To insure commutability (equivalence) between whole blood and plasma glucose values and to assess potential interferences in glucose oxidase methods. DESIGN AND METHODS:We compared plasma glucose results by the Ektachem 700 analyzer to glucose results on whole blood by the Nova Stat Profile 6, and by the YS...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Astles JR,Sedor FA,Toffaletti JG

    更新日期:1996-02-01 00:00:00

  • Triglyceride assay using the ABA-50 and Boehringer Mannheim Triglyceride reagent kit.

    abstract::1. A procedure for the assay of triglycerides on the ABA-50 is described. 2. The Boehringer Mannheim Triglyceride (Fully Enzymatic method) reagent kit has been evaluated with this method and was found to be satisfactory. ...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Owen VM,Tai OH

    更新日期:1977-12-01 00:00:00

  • Plasma TNF-R1 and insulin concentrations in relation to leptin levels among normal and overweight children.

    abstract:OBJECTIVES:Leptin is a multifunctional polypeptide produced primarily by adipocytes and associated with the occurrence of obesity and insulin resistance. Tumor necrosis factor-alpha (TNF-alpha), a polypeptide cytokine produced primarily by mononuclear phagocytes, plays a key role in the initiation of the inflammatory r...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Chu NF,Shen MH,Wu DM,Shieh SM

    更新日期:2002-06-01 00:00:00

  • Cystatin C as a predictor of all-cause mortality and myocardial infarction in patients with non-ST-elevation acute coronary syndrome.

    abstract:OBJECTIVES:To investigate the predictive value of cystatin C among patients diagnosed with non-ST-elevation acute coronary syndrome (nSTE-ACS). DESIGN AND METHODS:Admission serum samples from 245 nSTE-ACS patients were measured with a novel cystatin C immunoassay based on a dry-reagent, double monoclonal design. Creat...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Ristiniemi N,Lund J,Tertti R,Christensson A,Ilva T,Porela P,Pulkki K,Pettersson K

    更新日期:2012-05-01 00:00:00

  • Evaluation of low molecular mass thiols content in carotid atherosclerotic plaques.

    abstract:OBJECTIVES:Despite the evidence that both homocysteine and cysteine are important risk factors for vascular disease and atherosclerosis no information are reported about their effective amount in plaque and on the relationship with the other low molecular weight thiols. DESIGN AND METHODS:We used capillary electrophor...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Zinellu A,Lepedda A Jr,Sotgia S,Zinellu E,Scanu B,Turrini F,Spirito R,Deiana L,Formato M,Carru C

    更新日期:2009-06-01 00:00:00

  • AD biomarker discovery in CSF and in alternative matrices.

    abstract::Core Alzheimer's Disease (AD) biomarkers are the cerebrospinal fluid (CSF) proteins amyloid β42 and β40, and the tau proteins, total and phosphorylated. Their use is recommended by research guidelines for diagnostic purpose and for stratification of patients for clinical trials. However, novel potential biomarkers are...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章,评审


    authors: Sancesario G,Bernardini S

    更新日期:2019-10-01 00:00:00

  • Biochip arrays for the discovery of a biomarker surrogate in a phase I/II study assessing a novel anti-metastasis agent.

    abstract:OBJECTIVE:Can biochip arrays identify which individuals with metastatic disease will respond to an anti-metastatic agent? DESIGN AND METHODS:Cytokine and cell adhesion arrays (Randox Ltd) were measured over 1 month in 9 research participants receiving CTCE-9908 in a Phase I/II study. RESULTS:Research participants wit...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Kavsak PA,Henderson M,Moretto P,Hirte H,Evans K,Wong D,Korz W,Hotte SJ

    更新日期:2009-07-01 00:00:00

  • Fluorometric and time-resolved immunofluorometric assays for protein-tyrosine phosphatase activity.

    abstract:OBJECTIVE:To develop sensitive nonisotopic assays for protein-tyrosine phosphatase (PTP) activity. METHODS:The fluorometric assay is based on the fact that phosphotyrosine but not tyrosine forms highly fluorescent complexes with Tb3+. Thus, PTP activity can be followed by measuring the decrease of fluorescence due to ...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Galvan B,Christopoulos TK

    更新日期:1996-04-01 00:00:00

  • Increased glutathionylated hemoglobin (HbSSG) in type 2 diabetes subjects with microangiopathy.

    abstract:OBJECTIVE:Protein glutathionylation is considered an important post-translational modification in the pathogenesis of complex diseases. The aim of this study was to examine whether hemoglobin (Hb) is modified by reduced glutathione (GSH) via oxidation of the thiol groups present in diabetes and its associated microangi...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Sampathkumar R,Balasubramanyam M,Sudarslal S,Rema M,Mohan V,Balaram P

    更新日期:2005-10-01 00:00:00

  • Plasma visfatin and retinol binding protein-4 levels in patients with type 2 diabetes mellitus and their relationship to adiposity and fatty liver.

    abstract:OBJECTIVES:We investigated whether plasma visfatin and binding protein-4 (RBP-4) levels correlate with obesity and type 2 diabetes mellitus (T2DM). DESIGN AND METHODS:Two groups were enrolled: Group 1: 40 patients with T2DM and Group 2: 40 age- and gender-matched healthy controls. Both groups were subdivided according...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Shaker O,El-Shehaby A,Zakaria A,Mostafa N,Talaat S,Katsiki N,Mikhailidis DP

    更新日期:2011-12-01 00:00:00

  • Characterization of beta-galactosidase in leukocytes and fibroblasts of GM1 gangliosidosis heterozygotes compared to normal subjects.

    abstract:OBJECTIVES:Characterization of beta-galactosidase in leukocytes and fibroblasts of heterozygotes for GM1 type I. DESIGN AND METHODS:Leukocyte and fibroblast beta-galactosidase activity was determined fluorimetrically using 4-methylumbelliferyl-beta-D-galactoside as an artificial substrate. Optimum pH, Km, Vmax and the...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Sopelsa AM,Severini MH,Da Silva CM,Tobo PR,Giugliani R,Coelho JC

    更新日期:2000-03-01 00:00:00

  • Serum testosterone quantitation by liquid chromatography-tandem mass spectrometry: interference from blood collection tubes.

    abstract:OBJECTIVES:During the development of a testosterone assay by LC-MS/MS, we encountered significant assay interference introduced by blood collection tubes. We examined a number of commonly used blood collection tubes for the presence of interference and its impact on testosterone quantitation. DESIGN AND METHODS:A numb...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Shi RZ,van Rossum HH,Bowen RA

    更新日期:2012-12-01 00:00:00

  • Inter- and intra-individual variations in normal urinary glycine betaine excretion.

    abstract:OBJECTIVES:To establish whether normal human subjects excrete glycine betaine at a constant rate. DESIGN AND METHODS:Urine was collected from ten normal healthy male subjects for 14 days, during which fluid intake was systematically varied from <800 mL to >3 L per day. Glycine betaine, sorbitol and creatinine excretio...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Lever M,Atkinson W,Sizeland PC,Chambers ST,George PM

    更新日期:2007-04-01 00:00:00

  • A semi-automated enzymatic assay for free glycerol and triglycerides in serum or plasma.

    abstract::1. A relatively inexpensive semi-automated enzymatic procedure is described for the determination of total glycerol with an Auto Analyzer. Free glycerol is determined without saponification in a deproteinized supernatant. 2. The dilution of triglyceride samples during preparation is such that the samples during prepar...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: MacRae AR

    更新日期:1977-02-01 00:00:00

  • Observed relationship between ratios HDL-cholesterol/total cholesterol and apolipoprotein A1/apolipoprotein B.

    abstract::Epidemiological evidence suggests that the ratio HDL-cholesterol (HDL-C)/total cholesterol (TC) or apolipoprotein A1 (apo A1)/apolipoprotein B (apo B) are good indicators of coronary heart disease risk. In investigating the distribution of these ratios in the typical population served by our routine laboratory, we ana...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Kuyl JM,Mendelsohn D

    更新日期:1992-10-01 00:00:00