Cox proportional hazard model analysis of survival in end-stage renal disease patients with small-sized high-density lipoprotein particles.


OBJECTIVE:Dyslipidemia is commonly seen in patients with end-stage renal disease (ESRD). This prospective study investigates whether small-sized high-density lipoprotein (HDL) particles alone or in combination with high sensitivity C-reactive protein (hsCRP) are independent determinants of ESRD mortality. DESIGN AND METHODS:We performed 36 months follow-up study in 122 haemodialysis (HD) patients. HDL size and subclass distribution were determined by gradient gel electrophoresis. Baseline characteristics of the patients were evaluated for the prediction of mortality. RESULTS:Cox regressions analysis showed that patients with small-sized HDL particles had 2.8-fold higher risk of lethal outcome (P<0.05). Concomitant presence of small-sized HDL particles and increased hsCRP concentration were significantly associated with reduced survival rate (HR=3.907; P<0.05). Observed relationships persisted after adjustment for serum lipid and lipoprotein concentrations. CONCLUSIONS:Our results indicate that small-sized HDL particles alone and combined with elevated hsCRP concentrations are independent predictors of reduced survival in HD patients.


Clin Biochem


Clinical biochemistry


Vekic J,Zeljkovic A,Bogavac-Stanojevic N,Jelic-Ivanovic Z,Spasojevic-Kalimanovska V,Simic-Ogrizovic S,Dopsaj V,Spasic S




Has Abstract


2011-06-01 00:00:00














  • Ischemic acute kidney injury and klotho in renal transplantation.

    abstract::Post-transplant ischemic acute kidney injury (AKI), secondary to ischemia reperfusion injury (IRI), is a major problem influencing on the short and long term graft and patient survival. Many molecular and cellular modifications are observed during IRI, for example, tissue damage result production of reactive oxygen sp...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章,评审


    authors: Panah F,Ghorbanihaghjo A,Argani H,Asadi Zarmehri M,Nazari Soltan Ahmad S

    更新日期:2018-05-01 00:00:00

  • Elevated hemoglobin A1 in streptozotocin diabetic rats and in rats on sucrose and galactose-enriched diets.

    abstract::Increased hemoglobin A1 (HbA1) occurs in diabetes mellitus as a direct consequence of hyperglycemia, which causes postsynthetic modification of hemoglobin proportional to blood glucose concentration. Glycosylation of hemoglobin is demonstrable also in vitro, not only by glucose, but with other reducing sugars such as ...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Powell HC,Ivor LP,Costello ML,Wolf PL

    更新日期:1982-06-01 00:00:00

  • A multicenter evaluation of the Boehringer Mannheim ES 300 immunoassay system.

    abstract::The ES 300 system, a fully automated multichannel immunoassay analyzer, was evaluated simultaneously for 9 weeks in four major centers. Precision, accuracy, carryover, comparison to in-house methods, and interferences were assessed for the following 17 tests: T4, T3, FT4, TSH, TBK, TBG, LH, FSH, prolactin, HCG, digoxi...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章,多中心研究


    authors: D'Costa M,Feld R,Laxdal V,Trundle D,Collinsworth WL

    更新日期:1993-02-01 00:00:00

  • Utility of CA 15-3 and CEA in monitoring breast cancer patients with bone metastases: special emphasis on "spiking" phenomena.

    abstract:OBJECTIVES:CA 15-3 and CEA are considered useful tumor markers in monitoring breast cancer patients. This study was undertaken to specifically evaluate the transient elevations in these markers that are observed during systemic treatment for metastatic disease. This phenomenon has been termed "spiking." DESIGN AND MAT...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Yasasever V,Dinçer M,Camlica H,Karaloğlu D,Dalay N

    更新日期:1997-02-01 00:00:00

  • Simultaneous determination of fluoxetine and norfluoxetine in dried blood spots using high-performance liquid chromatography-tandem mass spectrometry.

    abstract:BACKGROUND:Therapeutic drug monitoring (TDM) of the widely prescribed antidepressant fluoxetine (FLU) is recommended in certain situations, such as occurrence of toxicity, inadequate response or suspect of poor adherence. Dried blood spot (DBS) sampling is an increasingly studied alternative for TDM, particularly for o...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: da Silva ACC,Raasch JR,Vargas TG,Peteffi GP,Hahn RZ,Antunes MV,Perassolo MS,Linden R

    更新日期:2018-02-01 00:00:00

  • Significant, quantifiable differences exist between IgG subclass standards WHO67/97 and ERM-DA470k and can result in different interpretation of results.

    abstract:OBJECTIVES:Accurate measurement of IgG subclass (IgGSc) levels are essential to aid in the diagnosis of disease states such as primary immunodeficiencies. However, there is no single standardisation of nephelometric and turbidimetric assays for these analytes and two reference materials have been utilised. We expand on...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Wilson C,Ebling R,Henig C,Adler T,Nicolaevski R,Barak M,Cazabon J,Maisin D,Lepoutre T,Gruson D,Hughes RG,Parker AR

    更新日期:2013-11-01 00:00:00

  • Cystatin C reference values and aging.

    abstract:OBJECTIVES:The aim of this study was to determine the reference values for serum cystatin C (CysC) with a particular focus on the effect of aging. DESIGN AND METHODS:The study was performed on a consecutive series of subjects (258 men and 396 women). Laboratory parameters and a detailed personal and family medical his...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Ognibene A,Mannucci E,Caldini A,Terreni A,Brogi M,Bardini G,Sposato I,Mosconi V,Salvadori B,Rotella CM,Messeri G

    更新日期:2006-06-01 00:00:00

  • Serum HER-2/neu in the management of breast cancer patients.

    abstract::The clinical role of HER-2/neu, a 185 kD epithelial transmembranous protein, has evolved after the approval of the anti-HER-2/neu targeted monoclonal antibody trastuzumab (Herceptin) for the therapy of metastatic breast cancer. The extracellular domain of HER-2/neu undergoes proteolytic cleavage from the full-length p...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章,评审


    authors: Lüftner D,Lüke C,Possinger K

    更新日期:2003-06-01 00:00:00

  • Influence of apolipoprotein(a) phenotype on lipoprotein(a) quantification: evaluation of three methods.

    abstract::Three commercially available assays (an enzyme-linked immunosorbent assay ELISA, an immunoradiometric assay, IRMA, and a nephelometric assay) for the determination of lipoprotein(a) [Lp(a)] were compared with respect to the dependency of these assays on the various apolipoprotein(a) [apo(a)] isoforms. Although there w...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Leus FR,Leerink CB,Prins J,van Rijn HJ

    更新日期:1994-12-01 00:00:00

  • The diagnostic value of apolipoprotein E in pediatric patients with invasive bacterial infections.

    abstract:OBJECTIVE:To evaluate the potential diagnostic value of apolipoprotein E (ApoE) measurements in pediatric patients with invasive bacterial infections. DESIGN AND METHOD:A total of 185 pediatric patients were enrolled in this study, including 94 patients with confirmable infections and 91 patients without confirmable i...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Wang C,Wang Y,Wang A,Fu P,Yang Y

    更新日期:2012-02-01 00:00:00

  • An audit of holotranscobalamin ("Active" B12) and methylmalonic acid assays for the assessment of vitamin B12 status: application in a mixed patient population.

    abstract:BACKGROUND:Vitamin B12 insufficiency/deficiency is common in mixed patient populations. However there is no single marker which can reliably diagnose B12 insufficiency/deficiency. Elevated concentrations of methylmalonic acid (MMA) are considered the most representative marker of metabolic vitamin B12 insufficiency, bu...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Sobczyńska-Malefora A,Gorska R,Pelisser M,Ruwona P,Witchlow B,Harrington DJ

    更新日期:2014-01-01 00:00:00

  • Measurement of oxidized lipoprotein (a) in patients with acute coronary syndromes and stable coronary artery disease by 2 ELISAs: using different capture antibody against oxidized lipoprotein (a) or oxidized LDL.

    abstract:OBJECTIVE:To evaluate clinical value of oxidized lipoprotein(a) [ox-Lp(a)] levels. DESIGN AND METHODS:Ox-Lp(a) were measured by 2 ELISAs using antibodies against ox-Lp(a) [ox-Lp(a)1] or oxidized low-density lipoprotein [ox-Lp(a)2], and studied in 161 acute coronary syndromes (ACS) patients, 114 stable coronary artery ...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Wang JJ,Han AZ,Meng Y,Gong JB,Zhang CN,Li K,Liu YX

    更新日期:2010-04-01 00:00:00

  • Comparative analysis of serum proteomes of patients with cardiovascular disease.

    abstract:OBJECTIVES:To monitor increases or decreases in cardiovascular disease (CVD)-related proteins that will be released from the deposits or plaque on the inner wall of blood vessels. DESIGN AND METHODS:Protein profiles of sera from healthy subjects and CVD patients were determined via 2-DE. Differentially expressed spots...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Kim HJ,Yoo HS,Kim PK,Kim MR,Lee HW,Kim CW

    更新日期:2011-02-01 00:00:00

  • High-performance liquid chromatographic method with column-switching and post-column reaction for determination of serotonin levels in platelet-poor plasma.

    abstract:OBJECTIVES:Measurement of serotonin concentrations in blood is considered to be important for the clinical studies of diseases involving vascular endothelial injury. We have developed a high-performance liquid chromatographic (HPLC) method for measurement of serotonin level in platelet-poor plasma (PPP). METHODS:Venou...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Hirowatari Y,Hara K,Kamihata H,Iwasaka T,Takahashi H

    更新日期:2004-03-01 00:00:00

  • The evaluation of autoantibodies against oxidatively modified low-density lipoprotein (LDL), susceptibility of LDL to oxidation, serum lipids and lipid hydroperoxide levels, total antioxidant status, antioxidant enzyme activities, and endothelial dysfunct

    abstract:OBJECTIVES:Behçet's disease is a multisystem disorder characterized by a chronic inflammation including acute attacks and remission periods. Decreased enzyme activity of the antioxidant system and increased levels of free radicals may have important roles in the damage of tissues observed in the disease period. In addi...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Orem A,Yandi YE,Vanizor B,Cimşit G,Uydu HA,Malkoç M

    更新日期:2002-05-01 00:00:00

  • Evaluation of the Dupont aca bromocresol purple albumin method.

    abstract::The bromocresol purple (BCP) albumin method on the DuPont aca was evaluated by determining the accuracy and precision of the method. A split sample comparison was performed against the electroimmunoassay (EIA) method as well as the bromocresol green (BCG) method on the DuPont aca and the Technicon SMA 12/60. The BCP m...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Krahn J

    更新日期:1983-04-01 00:00:00

  • Oxidative imbalance in low/intermediate-1-risk myelodysplastic syndrome patients: The influence of iron overload.

    abstract:OBJECTIVE:To assess the generation of reactive oxygen species (ROS) and the involvement of the main antioxidant pathways in low/intermediate-1-risk myelodysplastic syndromes (MDS) with iron overload (IOL). METHODS:We examined the levels of superoxide anion (O2-), hydrogen peroxide (H2O2), antioxidants (glutathione, GS...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Ivars D,Orero MT,Javier K,Díaz-Vico L,García-Giménez JL,Mena S,Tormos C,Egea M,Pérez PL,Arrizabalaga B,Ruiz MÁ,Yagüe N,Tormo M,Sancho-Tello R,Gomes A,Algueró C,O'Connor JE,Sáez GT,Carbonell F,Collado R

    更新日期:2017-11-01 00:00:00

  • USA hCG reference service, 10-year report.

    abstract:INTRODUCTION:The USA hCG Reference Service has been dealing with cases of persistent low levels of hCG and gestational trophoblastic diseases for 10years. Here we present the complete experience. METHODS:Total hCG in serum and urine was measured using the Siemen's Immulite 1000 assay. Hyperglycosylated hCG, nicked hCG...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Cole LA,Laidler LL,Muller CY

    更新日期:2010-08-01 00:00:00

  • Magnesium status and excretion in age-matched subjects with normal and elevated blood pressures.

    abstract::Plasma, erythrocyte, and leucocyte magnesium (Mg) concentration, as well as urinary Mg, calcium (Ca), and phosphorus (P) excretion were determined in male subjects with elevated diastolic blood pressure (DBP) > 90 mmHg. These parameters were compared to those in normotensive age-matched (DBP < 85 mmHg) and drug-treate...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Fischer PW,Belonje B,Giroux A

    更新日期:1993-06-01 00:00:00

  • Splice variants as cancer biomarkers.

    abstract::Inherited and acquired changes in pre-mRNA splicing have been documented to play a significant role in human disease development and many cancer-associated genes are regulated by alternative splicing. Loss of fidelity, variation of the splicing process, even controlled switching to specific splicing alternatives may o...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章,评审


    authors: Brinkman BM

    更新日期:2004-07-01 00:00:00

  • Quality assessment of microarray experiments.

    abstract:OBJECTIVES:We describe a quality assurance procedure to maximize the value of oligonucleotide microarray expression profiles. DESIGN, METHODS, AND RESULTS:Background microarray noise was 82.2+/-54.5 and 51.8+/-12.4 units, respectively, before and after enacting the program (P<0.0001). We also noted improved concordanc...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Carter DE,Robinson JF,Allister EM,Huff MW,Hegele RA

    更新日期:2005-07-01 00:00:00

  • The measurement of serum cholinesterase activities by an integration strategy with expanded linear ranges and negligible substrate-activation.

    abstract:OBJECTIVES:To measure serum cholinesterase (SCHE) with an integration strategy. DESIGN AND METHODS:At 54.0 micromol/L butyrylthiolcholine, SCHE initial rates were calculated with 50.0 micromol/L butyrylthiolcholine and maximal rates via an improved integrated method if substrate consumptions within 5.0 min were over 6...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Liao F,Yang D,Tang J,Yang X,Liu B,Zhao Y,Zhao L,Liao H,Yu M

    更新日期:2009-06-01 00:00:00

  • A method for determination of xylose utilizing glucose dehydrogenase.

    abstract::A method is described for xylose determination on the Ciba-Corning 550 Express that utilizes the slower enzymatic action of glucose dehydrogenase (GDH) on D-xylose, after prior removal of glucose. Glucose oxidase is added to serum or urine and incubated for 120 min at 37 degrees C. After incubation, a perchloric acid ...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Mori L

    更新日期:1994-02-01 00:00:00

  • Rapid inductively coupled plasma mass spectrometry method to determine iodine in amniotic fluid, breast milk and cerebrospinal fluid.

    abstract:BACKGROUND:Given that both insufficient and excess maternal iodine have adverse consequences such as poor cognitive performance, delayed physical development and increased fetal and infant mortality, the determination of maternal iodine status is very important. In this study, we established and verified a method invol...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Zou Y,Wang D,Yu S,Cheng X,Xia L,Yin Y,Xie S,Cheng Q,Qiu L,Lian X

    更新日期:2020-08-01 00:00:00

  • Simultaneous determination of glucose, triglycerides, urea, cholesterol, albumin and total protein in human plasma by Fourier transform infrared spectroscopy: direct clinical biochemistry without reagents.

    abstract:OBJECTIVE:Direct measurement of chemical constituents in complex biologic matrices without the use of analyte specific reagents could be a step forward toward the simplification of clinical biochemistry. Problems related to reagents such as production errors, improper handling, and lot-to-lot variations would be elimin...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Jessen TE,Höskuldsson AT,Bjerrum PJ,Verder H,Sørensen L,Bratholm PS,Christensen B,Jensen LS,Jensen MA

    更新日期:2014-09-01 00:00:00

  • How an enzyme works.

    abstract::The structure of enzyme active sites and the nature of the catalytic process are reviewed. The impressive efficiency of these protein catalysts appears to stem from such factors as proximity and orientation of enzyme and substrate moieties, strain, and the occurrence of distinctive microenvironments within catalytic c...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Blair AH

    更新日期:1976-06-01 00:00:00

  • Continuous reference intervals for 38 biochemical markers in healthy children and adolescents: Comparisons to traditionally partitioned reference intervals.

    abstract:BACKGROUND:Reference intervals have traditionally been partitioned by age based on statistical significance and physiological relevance. However, analyte concentration does not change abruptly with age, but rather dynamically. In this study, we establish biochemical marker continuous reference intervals for a Canadian ...

    journal_title:Clinical biochemistry

    pub_type: 临床试验,杂志文章


    authors: Asgari S,Higgins V,McCudden C,Adeli K

    更新日期:2019-11-01 00:00:00

  • Platelet activating factor (PAF) and activity of its biosynthetic and catabolic enzymes in blood and leukocytes of male patients with newly diagnosed heart failure.

    abstract:OBJECTIVES:To evaluate platelet activating factor (PAF) levels, its metabolic enzymes activity and its associations with other inflammatory markers in heart failure (HF) patients. DESIGN AND METHODS:PAF, and two of its key biosynthetic enzymes [lyso-PAF acetyltransferase (lyso-PAF-AT) and DTT-insensitive CDP-choline:1...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Detopoulou P,Nomikos T,Fragopoulou E,Antonopoulou S,Kotroyiannis I,Vassiliadou C,Panagiotakos DB,Chrysohoou C,Pitsavos C,Stefanadis C

    更新日期:2009-01-01 00:00:00

  • Low basal levels of circulating adiponectin in patients undergoing coronary stenting predict in-stent restenosis, independently of basal levels of inflammatory markers: lipoprotein associated phospholipase A2, and myeloperoxidase.

    abstract:OBJECTIVE:The aim of this study was to find a pre-interventional marker with the capacity to predict in-stent restenosis (ISR). Considering the anti-atherosclerotic role of adiponectin (APO), an adipocytokine with anti-inflammatory, anti-proliferative, anti-oxidative and anti-thrombotic properties, low plasma levels of...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Moldoveanu E,Mut-Vitcu B,Tanaseanu GR,Marta DS,Manea G,Kosaka T,Vidulescu C,Tanaseanu C

    更新日期:2008-12-01 00:00:00

  • Determination of serum vitamins 25-OH-D2 and 25-OH-D3 with liquid chromatography-tandem mass spectrometry using atmospheric pressure chemical ionization or electrospray source and core-shell or sub-2 μm particle columns: a comparative study.

    abstract:OBJECTIVE:Develop a simple LC-MS-MS method for determination of 25-hydroxymetabolites of vitamin D2 and D3 in serum. DESIGN AND METHODS:0.1 mL serum was mixed with 0.3 mL deproteinizing mixture containing two deuterated internal standards. Two LC-MS-MS systems were used: Waters Premier with an ESI source and a Hypersi...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Bogusz MJ,Al Enazi E,Tahtamoni M,Jawaad JA,Al Tufail M

    更新日期:2011-11-01 00:00:00