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Non-covalent associations of proteins in plasma: self-, mixed fibrin(ogen), mixed protein-non-protein associations.

Abstract：

OBJECTIVE:To review biochemical literature and determine the significance of non-covalent bonding in plasma. RESULTS:Many non-covalent bonds exist in plasma. Relatively strong self-associations are found for serum albumin, several gamma-globulins, apolipoproteins and fibrin(ogen). Here, fibrinogen and fibrin, considered one specie, react with other blood entities, building structures in plasma. A surface phenomenon analogous to viscosity is described for fibrin(ogen) which is useful in studying bonding. Combinations of lipids, proteins, polysaccharides and cellular elements form mixed associations. They add to the variety and number of non-covalent associations of proteins. Lipids make fairly strong associations. CONCLUSIONS:Fibrinogen binding may play a major role in organizing blood to develop primitive structure. Lipids too may add to forming large structures. Non-covalent bonds are very common in plasma, and blood may have to be considered as a quasi-structured tissue.

journal_name

Clin Biochem

journal_title

Clinical biochemistry

authors

London M

doi

10.1016/s0009-9120(96)00159-2

subject

Has Abstract

pub_date

1997-03-01 00:00:00

pages

83-9

issue

2

eissn

0009-9120

issn

1873-2933

pii

S0009-9120(96)00159-2

journal_volume

30

pub_type

杂志文章

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