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Plasma creatinine as a determinant of plasma total homocysteine concentrations in the Hordaland Homocysteine Study: use of statistical modeling to determine reference limits.

Abstract：

OBJECTIVES:We established population-based reference limits for plasma total homocysteine (tHcy) according to creatinine. DESIGN AND METHODS:In 7042 middle-aged and elderly subjects from the Hordaland Homocysteine Study, we used statistical modeling to establish nomograms for tHcy according to creatinine in the whole population and in folate-replete and healthy subgroups. RESULTS:When plotted against creatinine, tHcy 97.5th percentile almost overlapped in men and women, and, in elderly, increased up to 8 micromol/L from the 2.5th to 97.5th creatinine percentiles. Folate-replete subjects had tHcy upper limits approximately 20% below the whole population at all creatinine levels. Healthy subjects had lower creatinine, but at a given creatinine level, tHcy was the same as in the whole population. CONCLUSIONS:tHcy difference between men and women is mostly explained by creatinine. The tHcy-reducing effect of folate is independent of creatinine. In elderly people, creatinine should be taken into account when assessing tHcy levels.

journal_name

Clin Biochem

journal_title

Clinical biochemistry

authors

Elshorbagy AK,Oulhaj A,Konstantinova S,Nurk E,Ueland PM,Tell GS,Nygård O,Vollset SE,Refsum H

doi

10.1016/j.clinbiochem.2007.07.014

subject

Has Abstract

pub_date

2007-11-01 00:00:00

pages

1209-18

issue

16-17

eissn

0009-9120

issn

1873-2933

pii

S0009-9120(07)00299-8

journal_volume

40

pub_type

杂志文章

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