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Influence of apolipoprotein(a) phenotype on lipoprotein(a) quantification: evaluation of three methods.

Abstract：

:Three commercially available assays (an enzyme-linked immunosorbent assay ELISA, an immunoradiometric assay, IRMA, and a nephelometric assay) for the determination of lipoprotein(a) [Lp(a)] were compared with respect to the dependency of these assays on the various apolipoprotein(a) [apo(a)] isoforms. Although there was a strong correlation between the three methods, a significant difference between the absolute values (mg/L) was observed (p < 0.001). Using purified Lp(a) preparations, we showed that the ELISA assay quantifies the Lp(a) concentration on a molar basis, independently of the apo(a) isoform size. The IRMA and the nephelometric assay however are apo(a) isoform size dependent and overestimate the Lp(a) concentration of large apo(a) isoforms whereas the amount of small apo(a) isoforms is underestimated. In general, the isoform dependency of the Lp(a) quantification is of limited clinical relevance. In this study, inconsistent risk assignments are made in approximately 3% of the cases, when the Lp(a) concentrations obtained with the apo(a) isoform dependent assays are compared with the isoform independent ELISA.

journal_name

Clin Biochem

journal_title

Clinical biochemistry

authors

Leus FR,Leerink CB,Prins J,van Rijn HJ

doi

10.1016/0009-9120(94)00052-w

subject

Has Abstract

pub_date

1994-12-01 00:00:00

pages

449-55

issue

6

eissn

0009-9120

issn

1873-2933

pii

0009-9120(94)00052-W

journal_volume

27

pub_type

杂志文章

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