Homozygous bisalbuminemia or homozygous mutant albumin?

abstract：:Urine contains an enormous amount of information. Well-standardized procedures for collection, transport, sample preparation and analysis should become the basis of an effective diagnostic strategy for urinalysis. As reproducibility of urinalysis has been greatly improved due to recent technological progress, preanaly...

journal_title：Clinical biochemistry

authors： Delanghe JR,Speeckaert MM

更新日期：2016-12-01 00:00:00

abstract：OBJECTIVES:Blood sampling/handling alters matrix metalloproteinases (MMP) and tissue inhibitors of metalloproteinases (TIMP) expression. The aim of this study is to evaluate the effects of high molecular weight heparin on MMP and TIMP expression in blood. DESIGN AND METHODS:We analyzed by gelatin zymography and ELISA ...

journal_title：Clinical biochemistry

authors： Mannello F,Jung K,Tonti GA,Canestrari F

更新日期：2008-12-01 00:00:00

abstract：BACKGROUND:High levels of intact and cleaved forms of the urokinase-type plasminogen activator receptor (uPAR) in both tissue and blood are associated with poor survival in several cancer diseases. The prognostic significance of uPAR in cholangiocarcinoma is unknown. The aims of this study were to determine if pre-trea...

journal_title：Clinical biochemistry

authors： Grunnet M,Christensen IJ,Lassen U,Jensen LH,Lydolph M,Lund IK,Thurison T,Høyer-Hansen G,Mau-Sørensen M

更新日期：2014-05-01 00:00:00

abstract：BACKGROUND:The aim of this study was to investigate whether BGD activity is of additional value in the assessment of pulmonary inflammation caused by coal dust exposure. DESIGN AND METHODS:Ex-coalminers were included in this study. Forty-eight healthy male subjects, without a relevant medical history, were used as con...

journal_title：Clinical biochemistry

authors： Cobben NA,Drent M,De Vries J,Wouters EF,Van Dieijen-Visser MP,Henderson RF

更新日期：1999-11-01 00:00:00

abstract：OBJECTIVES:The aim of the study was to evaluate the concentration of interleukin 12 (IL-12), the activity of phospholipase A(2) (PLA(2)), and platelet-activating factor acetylhydrolase (PAF-AH) in type 1 diabetes (DM1) patients treated with intensive insulin therapy. DESIGN AND METHODS:Studied parameters were measured...

journal_title：Clinical biochemistry

authors： Wegner M,Araszkiewicz A,Pioruńska-Mikołajczak A,Zozulińska-Ziółkiewicz D,Wierusz-Wysocka B,Pioruńska-Stolzmann M

更新日期：2009-11-01 00:00:00

abstract：:Inherited and acquired changes in pre-mRNA splicing have been documented to play a significant role in human disease development and many cancer-associated genes are regulated by alternative splicing. Loss of fidelity, variation of the splicing process, even controlled switching to specific splicing alternatives may o...

journal_title：Clinical biochemistry

authors： Brinkman BM

更新日期：2004-07-01 00:00:00

abstract：:The effect of altered thyroid function on serum fructosamine concentrations was investigated in 31 untreated hyperthyroid patients, 18 short-term hypothyroid patients (i.e., 20 days after withdrawal of thyroid hormone suppressive therapy for thyroid cancer), 7 untreated long-term hypothyroid patients, and 25 age-match...

journal_title：Clinical biochemistry

authors： Cirillo R,Balzano S,Cossu E,Bartalena L,Solinas MP,Falcone M,Balestrieri A,Martino E

更新日期：1988-06-01 00:00:00

abstract：OBJECTIVES:We determined the frequencies of apolipoprotein E (apo E) gene alleles and examined the association between apo E polymorphism and lipid parameters in a sample of the Tunisian population. DESIGN AND METHODS:Apo E polymorphism was investigated using PCR, and plasma lipid parameters were measured in 122 men a...

journal_title：Clinical biochemistry

authors： Jemaa R,Elasmi M,Naouali C,Feki M,Kallel A,Souissi M,Sanhaji H,Hadj Taïeb S,Souheil O,Kaabachi N

更新日期：2006-08-01 00:00:00

abstract：BACKGROUND:Exercise is a prone condition to enhanced oxidative stress and damage and the specific activity pattern of a soccer match may favour additional pro-oxidant redox alterations. To date, no studies have reported the impact of a soccer match on oxidative stress and muscle damage markers. AIM:To analyse the effe...

journal_title：Clinical biochemistry

authors： Ascensão A,Rebelo A,Oliveira E,Marques F,Pereira L,Magalhães J

更新日期：2008-07-01 00:00:00

abstract：OBJECTIVES:Proinflammatory cytokines, matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) play a role in left ventricular (LV) structural remodeling. We aimed to investigate the effects of cardiac resynchronization therapy (CRT) on serum levels of amino-terminal prohormone B-type natriuretic peptide (N...

journal_title：Clinical biochemistry

authors： Stanciu AE,Vatasescu RG,Stanciu MM,Iorgulescu C,Vasile AI,Dorobantu M

更新日期：2013-02-01 00:00:00

abstract：BACKGROUND:Cystinosis is a rare autosomal recessive disorder characterized by an accumulation of intralysosomal cystine due to a defect in cystine transport across the lysosomal membrane. This disorder can be treated specifically using high doses of cysteamine. Accurate measurement of intracellular cystine content is n...

journal_title：Clinical biochemistry

authors： Chabli A,Aupetit J,Raehm M,Ricquier D,Chadefaux-Vekemans B

更新日期：2007-06-01 00:00:00

abstract：OBJECTIVE:Prior to initial distribution of Glucose-6-phosphate dehydrogenase (G6PD) proficiency testing (PT) materials, we evaluated G6PD enzyme stability in dried blood spots (DBS) under various temperature and humidity environments to develop storage and usage guidelines for our new materials. DESIGN & METHODS:We pr...

journal_title：Clinical biochemistry

authors： Flores SR,Hall EM,De Jesús VR

更新日期：2017-10-01 00:00:00

abstract：OBJECTIVES:Anti-Müllerian hormone (AMH) measurement is useful as an aid in the evaluation of ovarian reserve. In the past, its conventional use was restricted by the low-throughput and variability of existing manual AMH assays. We developed the automated Access AMH assay for the quantitative determination of AMH levels...

journal_title：Clinical biochemistry

authors： Demirdjian G,Bord S,Lejeune C,Masica R,Rivière D,Nicouleau L,Denizot P,Marquet PY

更新日期：2016-11-01 00:00:00

abstract：:We have modified the procedure for determining total metanephrines in urine described by Gupta, Price and Keane(1) to shorten the time necessary for completion while allowing the technician time to perform other tests. The modification involves the extraction of interfering substances from urine. Instead of having to ...

journal_title：Clinical biochemistry

authors： Fendley TW,Frings CS

更新日期：1976-04-01 00:00:00

abstract：OBJECTIVES:The new immunochemistry cobas e 801 module (Roche Diagnostics) was developed to meet increasing demands on routine laboratories to further improve testing efficiency, while maintaining high quality and reliable data. DESIGN AND METHODS:During a non-interventional multicenter evaluation study, the overall pe...

journal_title：Clinical biochemistry

authors： Findeisen P,Zahn I,Fiedler GM,Leichtle AB,Wang S,Soria G,Johnson P,Henzell J,Hegel JK,Bendavid C,Collet N,McGovern M,Klopprogge K

更新日期：2018-08-01 00:00:00

abstract：OBJECTIVES:Hepcidin is the main regulator of systemic iron homeostasis and its expression is modulated by iron status, hypoxia, erythroid factors and inflammation. The aim of our study was to examine a relationship between level of hepcidin and iron status, erythropoietic activity, hypoxia and inflammation in exacerbat...

journal_title：Clinical biochemistry

authors： Tandara L,Grubisic TZ,Ivan G,Jurisic Z,Tandara M,Gugo K,Mladinov S,Salamunic I

更新日期：2015-12-01 00:00:00

abstract：:We report a case of metastatic adenocarcinoma of the prostate with widespread bony and hepatic involvement having extremely high BB isoenzyme of creatine kinase in serum (2405 U/liter). The serum LD5/LD1 ratio is greater than one, with total LD activity more than twenty-five fold the normal value. The homogenate of pr...

journal_title：Clinical biochemistry

authors： Sandhu RS,Conover RE

更新日期：1980-02-01 00:00:00

abstract：OBJECTIVE:To externally validate a clinical decision rule incorporating heart fatty acid binding protein (h-FABP), high-sensitivity troponin (hs-cTn) and electrocardiogram (ECG) for the detection of acute myocardial infarction (AMI) on presentation to the Emergency Department. We also investigated whether this clinical...

journal_title：Clinical biochemistry

authors： Van Hise CB,Greenslade JH,Parsonage W,Than M,Young J,Cullen L

更新日期：2018-02-01 00:00:00

abstract：:Kallikreins are serine proteases with diverse physiologic functions. They are represented by multigene families in many animal species, especially in rat and mouse. Recently, the human kallikrein gene family has been fully characterized and includes 15 members, tandemly localized on chromosome 19q13.4. A new definitio...

journal_title：Clinical biochemistry

authors： Yousef GM,Diamandis EP

更新日期：2003-09-01 00:00:00

abstract：:Rheumatoid factors (RFs) have been studied for over 50 years and are probably the most written about of any antibody. Nevertheless, the etiology of these RFs and the precise role they play in the pathogenesis of rheumatoid arthritis (RA) and juvenile rheumatoid arthritis (JRA) remain a major interest. When RFs partici...

journal_title：Clinical biochemistry

authors： Moore TL,Dorner RW

更新日期：1993-04-01 00:00:00

abstract：OBJECTIVES:The glutathione S-transferases (GSTs) play a critical role in protecting the colorectal mucosa. We investigated the efficacy of using the GSTs activity of plasma as a biomarker of risk for colorectal cancer. METHODS:GSTs activity was measured in the plasma of control individuals (n=39) and in the plasma, tu...

journal_title：Clinical biochemistry

authors： Nomani H,Ghobadloo SM,Yaghmaei B,Rezvanie NA,Yaghmaei K

更新日期：2005-07-01 00:00:00

abstract：:The investigation of oxidative stress (OS), its mechanisms and connections with human diseases, is a topic of interest with more than 36,000 PubMed citations to date. The OS can be approached either from the perspective of pro-oxidation, either of anti-oxidation, and both can be investigated considering individual che...

journal_title：Clinical biochemistry

authors： Ialongo C

更新日期：2017-04-01 00:00:00

abstract：OBJECTIVE:Develop a simple LC-MS-MS method for determination of 25-hydroxymetabolites of vitamin D2 and D3 in serum. DESIGN AND METHODS:0.1 mL serum was mixed with 0.3 mL deproteinizing mixture containing two deuterated internal standards. Two LC-MS-MS systems were used: Waters Premier with an ESI source and a Hypersi...

journal_title：Clinical biochemistry

authors： Bogusz MJ,Al Enazi E,Tahtamoni M,Jawaad JA,Al Tufail M

更新日期：2011-11-01 00:00:00

abstract：OBJECTIVES:To compare the analysis of urinary albumin from diabetic patients by four conventional immunoassays including radioimmunoassay (RIA), immunonephelometry (IN), and two different methods of immunoturbidimetry (IT), as well as by high-performance liquid chromatography (HPLC). DESIGN AND METHODS:Urines were col...

journal_title：Clinical biochemistry

authors： Comper WD,Jerums G,Osicka TM

更新日期：2004-02-01 00:00:00

abstract：OBJECTIVES:We checked the efficiency of a new dialysis device adapted to small volumes to remove glycerol from cryopreserved red blood cells. DESIGN AND METHODS:Dialysis was performed on D-Tube96™ Dialyzer Mini device. In a preliminary trial, we measured the residual glycerol before, and 2, 4 and 24 h after dialysis. ...

journal_title：Clinical biochemistry

authors： Zerimech F,Huyvaert H,Matran R,Nadif R

更新日期：2011-06-01 00:00:00

abstract：OBJECTIVE:We seek to identify the differentially expressed miRNAs in the clear cell subtype (ccRCC) of kidney cancer. DESIGN AND METHODS:We performed a miRNA microarray analysis to compare the miRNA expression levels between ccRCC tissues and their normal counterpart. The top dysregulated miRNAs were validated by quan...

journal_title：Clinical biochemistry

authors： Chow TF,Youssef YM,Lianidou E,Romaschin AD,Honey RJ,Stewart R,Pace KT,Yousef GM

更新日期：2010-01-01 00:00:00

abstract：OBJECTIVE:A multisite investigation compared the analytical performance of a point-of-care (POC) HbA1c device with multiple commonly used HbA1c laboratory methods and an NGSP (National Glycohemoglobin Standardization Program) reference method. RESEARCH DESIGN AND METHODS:The Afinion AS100 POC device analyzed HbA1c usi...

journal_title：Clinical biochemistry

authors： Sobolesky PM,Smith BE,Saenger AK,Schulz K,Apple FS,Scott MG,Wu AHB,Little RR,Fitzgerald RL

更新日期：2018-11-01 00:00:00

abstract：OBJECTIVE:To evaluate relationships between apolipoprotein B (Apo B), LDL cholesterol (LDL-C), and non-HDL-C in high-risk patients treated with lipid-lowering therapy. DESIGN AND METHODS:This post-hoc analysis calculated LDL-C and non-HDL-C levels corresponding to an Apo B of 0.9 g/L following treatment with 1) statin...

journal_title：Clinical biochemistry

authors： Vaverkova H,Farnier M,Averna M,Missault L,Viigimaa M,Dong Q,Shah A,Johnson-Levonas AO,Brudi P

更新日期：2011-06-01 00:00:00

abstract：:57Co-cyanocobalamin is substituted for iodine labeled antigen in three commercially available solid phase radioimmunoassay kits to evaluate the extent of non-specific binding by determination of the supernatant and residual fraction of unbound ligand and thus obtain a value for corrected binding throughout the range o...

journal_title：Clinical biochemistry

authors： Carter P

更新日期：1978-06-01 00:00:00

abstract：:High-sensitivity cardiac troponin (hs-cTn) assays have been used clinically by thousands of physicians in many countries throughout the world since their clinical introduction seven years ago. In the early diagnosis of myocardial infarction (MI), beyond doubt the most important indication of hs-cTn assays, these simpl...

journal_title：Clinical biochemistry

authors： Twerenbold R,Boeddinghaus J,Nestelberger T,Wildi K,Rubini Gimenez M,Badertscher P,Mueller C

更新日期：2018-03-01 00:00:00