Abstract：
:High-sensitivity cardiac troponin (hs-cTn) assays have been used clinically by thousands of physicians in many countries throughout the world since their clinical introduction seven years ago. In the early diagnosis of myocardial infarction (MI), beyond doubt the most important indication of hs-cTn assays, these simple, inexpensive and highly reproducible tools complement detailed clinical assessment including chest pain characteristics and the electrocardiogram. Hs-cTn assays for the first time allowed the precise quantification of cardiomyocyte injury around the 99th percentile and thereby substantially increased the accuracy of MI detection from blood obtained at presentation to the emergency department (ED). Higher accuracy at ED presentation enabled the development and extensive validation of early hs-cTn-based diagnostic algorithms, which substantially reduced the time required for the safe rule-out or rule-in of MI. This review summarizes key principles underlying the safe and effective use of hs-cTn in the ED in patients with suspected MI.
journal_name
Clin Biochemjournal_title
Clinical biochemistryauthors
Twerenbold R,Boeddinghaus J,Nestelberger T,Wildi K,Rubini Gimenez M,Badertscher P,Mueller Cdoi
10.1016/j.clinbiochem.2017.12.006subject
Has Abstractpub_date
2018-03-01 00:00:00pages
143-155eissn
0009-9120issn
1873-2933pii
S0009-9120(17)31037-8journal_volume
53pub_type
杂志文章,评审abstract：:The current review presents the results of the most recent studies performed on different aspects of human head and neck squamous cell carcinoma, including radiosensitivity induction, efficiency improvement of monoclonal antibodies using low-intensity ultrasound, chemical compounds such as toll-like receptor (TLC) ago...
journal_title：Clinical biochemistry
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