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Glutathione S-transferases activity in patients with colorectal cancer.

Abstract：

OBJECTIVES:The glutathione S-transferases (GSTs) play a critical role in protecting the colorectal mucosa. We investigated the efficacy of using the GSTs activity of plasma as a biomarker of risk for colorectal cancer. METHODS:GSTs activity was measured in the plasma of control individuals (n=39) and in the plasma, tumor tissue and normal tissue adjacent to a tumor of patients with colorectal cancer taken at colonoscopy (n=60). RESULTS:Mean GSTs activity was significantly (P< 0.01) higher in tumors (242+/- 45 nmol/min mg protein) as compared to normal tissues adjacent to a tumor (84+/- 49 nmol/min mg protein). A significant correlation between normal tissues adjacent to a tumor GSTs with those in malignant tissues was observed (r=0.61). Plasma GSTs activity was significantly (P<0.0001) higher in colorectal cancer patients (164+/-11 nmol/min mL) than those obtained from normal individuals (92+/- 23 nmol/min mL). CONCLUSIONS:GSTs measurement may be useful as a colorectal cancer marker in colorectal cancer, and biopsies obtained at colonoscopy can be used to measure tumor markers.

journal_name

Clin Biochem

journal_title

Clinical biochemistry

authors

Nomani H,Ghobadloo SM,Yaghmaei B,Rezvanie NA,Yaghmaei K

doi

10.1016/j.clinbiochem.2005.04.004

subject

Has Abstract

pub_date

2005-07-01 00:00:00

pages

621-4

issue

7

eissn

0009-9120

issn

1873-2933

pii

S0009-9120(05)00096-2

journal_volume

38

pub_type

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