当前位置： SCI文献检索 > CLINICAL BIOCHEMISTRY期刊下所有文献 > Differential expression profiling of microRNAs and their potential involvement in renal cell carcinoma pathogenesis.

Differential expression profiling of microRNAs and their potential involvement in renal cell carcinoma pathogenesis.

Abstract：

OBJECTIVE:We seek to identify the differentially expressed miRNAs in the clear cell subtype (ccRCC) of kidney cancer. DESIGN AND METHODS:We performed a miRNA microarray analysis to compare the miRNA expression levels between ccRCC tissues and their normal counterpart. The top dysregulated miRNAs were validated by quantitative RT-PCR analysis. Bioinformatics analysis was also performed. RESULTS:A total of 33 dysregulated miRNAs were identified in ccRCC, including 21 upregulated miRNAs and many of these miRNAs have been reported to be dysregulated in other malignancies and have a potential role in cancer pathogenesis. The miRNAs showed a significant correlation with reported chromosomal aberration sites. We also utilized target prediction algorithms to identify gene targets. Preliminary analyses showed these targets can be directly involved in RCC pathogenesis. CONCLUSION:We identified miRNAs that are dysregulated in ccRCC and bioinformatics analysis suggests that these miRNAs may be involved in cancer pathogenesis and have the potential to be biomarkers.

journal_name

Clin Biochem

journal_title

Clinical biochemistry

authors

Chow TF,Youssef YM,Lianidou E,Romaschin AD,Honey RJ,Stewart R,Pace KT,Yousef GM

doi

10.1016/j.clinbiochem.2009.07.020

subject

Has Abstract

pub_date

2010-01-01 00:00:00

pages

150-8

issue

1-2

eissn

0009-9120

issn

1873-2933

pii

S0009-9120(09)00319-1

journal_volume

43

pub_type

杂志文章

相关文献

CLINICAL BIOCHEMISTRY文献大全
  • Characterization of beta-galactosidase in leukocytes and fibroblasts of GM1 gangliosidosis heterozygotes compared to normal subjects.

    abstract：OBJECTIVES:Characterization of beta-galactosidase in leukocytes and fibroblasts of heterozygotes for GM1 type I. DESIGN AND METHODS:Leukocyte and fibroblast beta-galactosidase activity was determined fluorimetrically using 4-methylumbelliferyl-beta-D-galactoside as an artificial substrate. Optimum pH, Km, Vmax and the...

    journal_title：Clinical biochemistry

    pub_type： 杂志文章

    doi：10.1016/s0009-9120(00)00049-7

    authors： Sopelsa AM,Severini MH,Da Silva CM,Tobo PR,Giugliani R,Coelho JC

    更新日期：2000-03-01 00:00:00

  • Vitamins D and A can be successfully measured by LC-MS/MS in cord blood diluted plasma.

    abstract：OBJECTIVES:In widely used protocols for the collection and isolation of cord blood mononuclear cells, investigators are left with substantial volumes of diluted plasma which could be used for other measurements. The aim of this study was to ascertain the validity of umbilical cord blood (UCB) diluted plasma samples for...

    journal_title：Clinical biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.clinbiochem.2015.04.014

    authors： Albarhani AA,Collier F,Greaves RF,Ponsonby AL,Allen KJ,Vuillermin PJ,Roche P,Clarke MW,BIS Steering Committee.

    更新日期：2015-11-01 00:00:00

  • Evaluation of plasma ammonia levels in patients with acute liver failure and chronic liver disease and its correlation with the severity of hepatic encephalopathy and clinical features of raised intracranial tension.

    abstract：OBJECTIVES:The present study was designed to (a) evaluate and compare plasma ammonia levels (PAL) in patients with acute liver failure (ALF) and chronic liver disease (CLD) with or without hepatic encephalopathy (HE); (b) correlate the severity of HE with PAL; and (c) correlate PAL with clinical features of raised intr...

    journal_title：Clinical biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.clinbiochem.2005.04.013

    authors： Kundra A,Jain A,Banga A,Bajaj G,Kar P

    更新日期：2005-08-01 00:00:00

  • Simultaneous determination of glucose, triglycerides, urea, cholesterol, albumin and total protein in human plasma by Fourier transform infrared spectroscopy: direct clinical biochemistry without reagents.

    abstract：OBJECTIVE:Direct measurement of chemical constituents in complex biologic matrices without the use of analyte specific reagents could be a step forward toward the simplification of clinical biochemistry. Problems related to reagents such as production errors, improper handling, and lot-to-lot variations would be elimin...

    journal_title：Clinical biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.clinbiochem.2014.05.064

    authors： Jessen TE,Höskuldsson AT,Bjerrum PJ,Verder H,Sørensen L,Bratholm PS,Christensen B,Jensen LS,Jensen MA

    更新日期：2014-09-01 00:00:00

  • Hyaluronic acid as a non-invasive biomarker of liver fibrosis.

    abstract：UNLABELLED:Chronic liver diseases may cause inflammation and progressive scarring, over time leading to irreversible hepatic damage (cirrhosis). As a result, the need to assess and closely monitor individuals for risk factors of components of matrix deposition and degradation, as well as the severity of the fibrosis us...

    journal_title：Clinical biochemistry

    pub_type： 杂志文章,评审

    doi：10.1016/j.clinbiochem.2015.07.019

    authors： Neuman MG,Cohen LB,Nanau RM

    更新日期：2016-02-01 00:00:00

  • Evaluation of the ARCHITECT urine NGAL assay: assay performance, specimen handling requirements and biological variability.

    abstract：OBJECTIVES:NGAL (Neutrophil Gelatinase-Associated Lipocalin) has emerged as a new biomarker for the identification of acute kidney injury. Reliable clinical evaluations require a simple, robust test method for NGAL, and knowledge of specimen handling and specimen stability characteristics. We evaluated the performance ...

    journal_title：Clinical biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.clinbiochem.2009.12.008

    authors： Grenier FC,Ali S,Syed H,Workman R,Martens F,Liao M,Wang Y,Wong PY

    更新日期：2010-04-01 00:00:00

  • Non-covalent associations of proteins in plasma: self-, mixed fibrin(ogen), mixed protein-non-protein associations.

    abstract：OBJECTIVE:To review biochemical literature and determine the significance of non-covalent bonding in plasma. RESULTS:Many non-covalent bonds exist in plasma. Relatively strong self-associations are found for serum albumin, several gamma-globulins, apolipoproteins and fibrin(ogen). Here, fibrinogen and fibrin, consider...

    journal_title：Clinical biochemistry

    pub_type： 杂志文章

    doi：10.1016/s0009-9120(96)00159-2

    authors： London M

    更新日期：1997-03-01 00:00:00

  • 1,5-anhydroglucitol monitoring in diabetes: a mass balance perspective.

    abstract：:1,5-anhydroglucitol (AG) is a nonmetabolizable glucose analogue found in plasma due to ingestion. The normal steady-state concentration can be dramatically decreased by inhibition of tubular reabsorption during periods of hyperglycemia. For this reason, monitoring of AG has been plausibly advocated for detection of pe...

    journal_title：Clinical biochemistry

    pub_type： 杂志文章,评审

    doi：10.1016/j.clinbiochem.2008.08.086

    authors： Nerby CL,Stickle DF

    更新日期：2009-02-01 00:00:00

  • Do wine polyphenols modulate p53 gene expression in human cancer cell lines?

    abstract：BACKGROUND:The p53 gene is an established tumor suppressor and an inducer of apoptosis. We here attempt to determine whether the putative anticarcinogenic properties attributed to red wine and its polyphenolic constituents depend, at least in part, upon their ability to modulate p53 expression in cancer cells. METHODS...

    journal_title：Clinical biochemistry

    pub_type： 杂志文章

    doi：10.1016/s0009-9120(01)00246-6

    authors： Soleas GJ,Goldberg DM,Grass L,Levesque M,Diamandis EP

    更新日期：2001-07-01 00:00:00

  • Rapid and quantitative detection of CpG-methylation status using TaqMan PCR combined with methyl-binding-domain polypeptide.

    abstract：OBJECTIVES:To assess the medical applicability of CpG methylation as molecular markers for cancer diagnosis, we established a new system to determine DNA methylation based on TaqMan PCR combined with a methyl-binding-domain polypeptide 2. DESIGN AND METHODS:We evaluated the diagnostic applicability of this approach by...

    journal_title：Clinical biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.clinbiochem.2009.03.017

    authors： Kimura N,Moribe T,Iizuka N,Miura T,Tamatsukuri S,Ishitsuka H,Hamamoto Y,Oka M

    更新日期：2009-07-01 00:00:00

  • Biochemical markers of bone metabolism: an overview.

    abstract：OBJECTIVES:An overview of biochemical markers of bone metabolism is presented along with indications for their clinical utilization. DESIGN AND METHODS:The structure, cyclical metabolism, and hormone regulation of bone is reflected by markers of resorption, formation and/or turnover. Markers of resorption representing...

    journal_title：Clinical biochemistry

    pub_type： 杂志文章,评审

    doi：10.1016/s0009-9120(97)00113-6

    authors： Christenson RH

    更新日期：1997-12-01 00:00:00

  • Differences in urinary albumin detected by four immunoassays and high-performance liquid chromatography.

    abstract：OBJECTIVES:To compare the analysis of urinary albumin from diabetic patients by four conventional immunoassays including radioimmunoassay (RIA), immunonephelometry (IN), and two different methods of immunoturbidimetry (IT), as well as by high-performance liquid chromatography (HPLC). DESIGN AND METHODS:Urines were col...

    journal_title：Clinical biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.clinbiochem.2003.10.008

    authors： Comper WD,Jerums G,Osicka TM

    更新日期：2004-02-01 00:00:00

  • Heart-type fatty acid binding protein in elective cardioversion of atrial fibrillation.

    abstract：OBJECTIVES:We sought to investigate whether heart-type fatty acid binding protein (H-FABP), a new marker of myocardial necrosis, increases in relation to elective cardioversion of atrial fibrillation (AF). METHODS:We studied 25 consecutive patients (61 ± 16 years old, 21 men) admitted to our hospital for elective card...

    journal_title：Clinical biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.clinbiochem.2011.05.029

    authors： Sbarouni E,Georgiadou P,Chaidaroglou A,Degiannis D,Voudris V

    更新日期：2011-08-01 00:00:00

  • Biochemical characterization of chitotriosidase enzyme: comparison between normal individuals and patients with Gaucher and with Niemann-Pick diseases.

    abstract：OBJECTIVES:The aim of the present study was to establish the range of chitotriosidase (CT) activity in normal individuals, patients with Gaucher disease (GD) and Niemann-Pick disease (NPD), types A or B. The kinetics of CT in these three groups was also investigated. DESIGN AND METHODS:CT activity, as well as Km, Vmax...

    journal_title：Clinical biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.clinbiochem.2004.06.008

    authors： Wajner A,Michelin K,Burin MG,Pires RF,Pereira ML,Giugliani R,Coelho JC

    更新日期：2004-10-01 00:00:00

  • Technological trends in clinical laboratory science.

    abstract：OBJECTIVE:This article will review the advancements and new developments being made in (1) advanced computers, (2) microtechnology, (3) advanced immunodiagnostics, (4) neural networks, and (5) molecular biology. The influence of these technologies and their products on clinical laboratories is also discussed. CONCLUSI...

    journal_title：Clinical biochemistry

    pub_type： 杂志文章,评审

    doi：10.1016/0009-9120(94)00075-7

    authors： Burtis CA

    更新日期：1995-06-01 00:00:00

  • Biobanking 3.0: evidence based and customer focused biobanking.

    abstract：:Biobanking is a new and very dynamic field. To achieve long term financial sustainability of biobank infrastructures we propose that a new focus is needed on activities, products and services provided by the biobank that relate to the external stakeholder: biobanking 3.0. Earlier stages of biobanking are biobanking 1....

    journal_title：Clinical biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.clinbiochem.2013.12.018

    authors： Simeon-Dubach D,Watson P

    更新日期：2014-03-01 00:00:00

  • The evaluation of autoantibodies against oxidatively modified low-density lipoprotein (LDL), susceptibility of LDL to oxidation, serum lipids and lipid hydroperoxide levels, total antioxidant status, antioxidant enzyme activities, and endothelial dysfunct

    abstract：OBJECTIVES:Behçet's disease is a multisystem disorder characterized by a chronic inflammation including acute attacks and remission periods. Decreased enzyme activity of the antioxidant system and increased levels of free radicals may have important roles in the damage of tissues observed in the disease period. In addi...

    journal_title：Clinical biochemistry

    pub_type： 杂志文章

    doi：10.1016/s0009-9120(02)00290-4

    authors： Orem A,Yandi YE,Vanizor B,Cimşit G,Uydu HA,Malkoç M

    更新日期：2002-05-01 00:00:00

  • Receiver-operating characteristics of adjusted urine measurements of oxycodone plus metabolites to distinguish between three different rates of oxycodone administration.

    abstract：OBJECTIVES:In a study by Couto et al. (Use of an algorithm applied to urine drug screening to assess adherence to an oxycontin regimen. J Opioid Manag 2009;5:359-64), adjusted urine measurements of oxycodone plus metabolites noroxycodone and oxymorphone were determined among volunteer subjects in three groups according...

    journal_title：Clinical biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.clinbiochem.2012.09.016

    authors： McCloskey LJ,Dellabadia KA,Stickle DF

    更新日期：2013-01-01 00:00:00

  • Matrix metalloproteinase7 -181A/G polymorphism is associated with increased cancer risk among high-quality studies: Evidence from a meta-analysis.

    abstract：OBJECTIVES:To evaluate the effect of Matrix metalloproteinase 7 -181A/G polymorphism (rs11568818) on the risk of cancer, we performed a meta-analysis. DESIGN AND METHODS:24 case-control studies were identified by searching Pubmed, Embase, ISI, OVID MEDLINE and EBSCO databases. Odd ratios and corresponding 95% confiden...

    journal_title：Clinical biochemistry

    pub_type： 杂志文章,meta分析

    doi：10.1016/j.clinbiochem.2013.07.015

    authors： Wu J,Guan X,Li YT,Bai P,Wu J

    更新日期：2013-11-01 00:00:00

  • A survey to identify potential outcome indicators for a hospital blood glucose monitoring program.

    abstract：OBJECTIVE:A survey of operators of a bedside blood glucose monitoring (BGM) program at a tertiary health care institution was performed to identify potential outcome indicators for our quality assurance program. DESIGN AND METHODS:170 surveys were randomly distributed to each nursing unit. The survey consisted of 20 q...

    journal_title：Clinical biochemistry

    pub_type： 杂志文章

    doi：10.1016/s0009-9120(98)00020-4

    authors： Collier CP,Houlden RL,Gleeson KA,Patrzykat A,Rhymer SL

    更新日期：1998-06-01 00:00:00

  • Rapid inductively coupled plasma mass spectrometry method to determine iodine in amniotic fluid, breast milk and cerebrospinal fluid.

    abstract：BACKGROUND:Given that both insufficient and excess maternal iodine have adverse consequences such as poor cognitive performance, delayed physical development and increased fetal and infant mortality, the determination of maternal iodine status is very important. In this study, we established and verified a method invol...

    journal_title：Clinical biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.clinbiochem.2020.03.009

    authors： Zou Y,Wang D,Yu S,Cheng X,Xia L,Yin Y,Xie S,Cheng Q,Qiu L,Lian X

    更新日期：2020-08-01 00:00:00

  • The effects of bisphenol A (BPA) exposure on fat mass and serum leptin concentrations have no impact on bone mineral densities in non-obese premenopausal women.

    abstract：OBJECTIVES:Bisphenol A (BPA) exposure may promote obesity, but its effect on bone mineral density (BMD) has not been reported in humans. We aimed to examine the relationships between BPA exposure, body composition, serum estradiol, leptin, osteocalcin levels and BMDs in healthy premenopausal women. DESIGN AND METHODS:...

    journal_title：Clinical biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.clinbiochem.2012.08.024

    authors： Zhao HY,Bi YF,Ma LY,Zhao L,Wang TG,Zhang LZ,Tao B,Sun LH,Zhao YJ,Wang WQ,Li XY,Xu MY,Chen JL,Ning G,Liu JM

    更新日期：2012-12-01 00:00:00

  • The effects of chemically synthesized saposin C on glucosylceramide-β-glucosidase.

    abstract：OBJECTIVE:Saposin C (SAP-C) is an essential activator of glucosylceramide (GlcCer)-β-glucosidase (GCase), the enzyme deficient in Gaucher's disease. In this study, we investigated the effects of chemically synthesized SAP-Cs (synthetic SAP-Cs) on GCase. METHODS:Enzymatic assays and western blot analyses were carried o...

    journal_title：Clinical biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.clinbiochem.2015.06.004

    authors： Yoneshige A,Muto M,Watanabe T,Hojo H,Matsuda J

    更新日期：2015-11-01 00:00:00

  • Performance of flow cytometry to screen urine for bacteria and white blood cells prior to urine culture.

    abstract：BACKGROUND:The gold standard test for the diagnosis of urinary tract infection is bacterial culture. However, urine cultures are labor intensive and costly. Furthermore, since results take 1-2 days many patients are treated presumptively prior to culture results being known. METHODS:We evaluated the Sysmex UF-1000i fo...

    journal_title：Clinical biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.clinbiochem.2013.03.005

    authors： Giesen CD,Greeno AM,Thompson KA,Patel R,Jenkins SM,Lieske JC

    更新日期：2013-06-01 00:00:00

  • Establishment of reference intervals for the salivary cortisol circadian cycle, by electrochemiluminescence (ECLIA), in healthy adults.

    abstract：OBJECTIVES:To determine salivary cortisol reference intervals in a healthy adult population, at 6 different time points during a 24-hour (h) period. METHODS:In a prospective study, salivary cortisol concentrations were measured upon waking, one-hour post-waking and at specific times of the day: at 12 h00, 16 h00, 20 h...

    journal_title：Clinical biochemistry

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.clinbiochem.2018.02.012

    authors： Gagnon N,Fréchette I,Mallet PL,Dubé J,Houde G,Fink GD

    更新日期：2018-04-01 00:00:00

  • Genetic risk factors for renal failure among north Indian ESRD patients.

    abstract：OBJECTIVES:Angiotensin converting enzyme (ACE), G-Protein couple receptor (G-Prot), endothelial nitric oxide synthase (ecNOS), Leptin -2548G/A and uncoupling protein (UCP2) are potent regulators of intra renal hemodynamics and may be the causative factors contributing to the deterioration of renal functions. In recent ...

    journal_title：Clinical biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.clinbiochem.2008.01.009

    authors： Tripathi G,Sharma RK,Baburaj VP,Sankhwar SN,Jafar T,Agrawal S

    更新日期：2008-05-01 00:00:00

  • Homozygous bisalbuminemia or homozygous mutant albumin?

    abstract：INTRODUCTION:Bisalbuminemia is a genetic condition in which an albumin variant is found in serum in addition to normal albumin. METHODS AND MATERIALS:Serum protein electrophoresis using the Sebia HYDRASYS electrophoresis system was performed on an 84 year old male. RESULTS:Serum protein electrophoresis showed a singl...

    journal_title：Clinical biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.clinbiochem.2011.10.005

    authors： Kulkarni K,Rowe P,Christensen CL,Higgins T

    更新日期：2012-01-01 00:00:00

  • How to best use high-sensitivity cardiac troponin in patients with suspected myocardial infarction.

    abstract：:High-sensitivity cardiac troponin (hs-cTn) assays have been used clinically by thousands of physicians in many countries throughout the world since their clinical introduction seven years ago. In the early diagnosis of myocardial infarction (MI), beyond doubt the most important indication of hs-cTn assays, these simpl...

    journal_title：Clinical biochemistry

    pub_type： 杂志文章,评审

    doi：10.1016/j.clinbiochem.2017.12.006

    authors： Twerenbold R,Boeddinghaus J,Nestelberger T,Wildi K,Rubini Gimenez M,Badertscher P,Mueller C

    更新日期：2018-03-01 00:00:00

  • Enzymatic imbalance in peripheral blood mononuclear cells isolated from individuals with anti-HIV antibodies.

    abstract：:Plasma membrane-bound 5'-nucleotidase (5'-NT), gamma-glutamyltransferase (gamma-GT) and soluble deoxynucleotidyltransferase (TdT) were studied in peripheral blood cells (PBMN) of 35 individuals, 26 male and 9 female, with circulating anti-HIV antibodies. Twenty-six were drug abusers, 2 were drug abusers and homosexual...

    journal_title：Clinical biochemistry

    pub_type： 杂志文章

    doi：10.1016/s0009-9120(89)80026-8

    authors： Losa GA

    更新日期：1989-08-01 00:00:00

  • Comparison of fluorescent immunoassay (FIA) and enzyme-multiplied immunoassay technique (EMIT) for measurement of serum carbamazepine concentration.

    abstract：:The recently developed fluorescent immunoassay (FIA) for measuring serum carbamazepine concentration is compared to the established enzyme-multiplied-immunoassay-technique (EMIT). The Accuracy, precision and simplicity of these methods are comparable. The sensitivity of FIA is approximately eight times greater than th...

    journal_title：Clinical biochemistry

    pub_type： 杂志文章

    doi：10.1016/s0009-9120(82)96854-0

    authors： Carl GF,Smith DB,Dunn LP

    更新日期：1982-12-01 00:00:00