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Matrix metalloproteinase7 -181A/G polymorphism is associated with increased cancer risk among high-quality studies: Evidence from a meta-analysis.

Abstract：

OBJECTIVES:To evaluate the effect of Matrix metalloproteinase 7 -181A/G polymorphism (rs11568818) on the risk of cancer, we performed a meta-analysis. DESIGN AND METHODS:24 case-control studies were identified by searching Pubmed, Embase, ISI, OVID MEDLINE and EBSCO databases. Odd ratios and corresponding 95% confidence intervals were applied to assess the strength of association between MMP7 -181A/G polymorphism and cancer risk. RESULTS:Between MMP7 -181GG genotype and cancer risk, statistically significant association could be observed from overall cancer risk, evidently noted in Asians, observed in high-quality subgroup, and apparently witnessed in PCR-RFLP genotyping subgroup. CONCLUSIONS:Our meta-analysis indicates that MMP7 -181GG genotype is associated with overall cancer risk in Asian populations (especially China and India) among high-quality studies.

journal_name

Clin Biochem

journal_title

Clinical biochemistry

authors

Wu J,Guan X,Li YT,Bai P,Wu J

doi

10.1016/j.clinbiochem.2013.07.015

subject

Has Abstract

pub_date

2013-11-01 00:00:00

pages

1649-54

issue

16-17

eissn

0009-9120

issn

1873-2933

pii

S0009-9120(13)00348-2

journal_volume

46

pub_type

杂志文章,meta分析

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