Abstract:
OBJECTIVES:NGAL (Neutrophil Gelatinase-Associated Lipocalin) has emerged as a new biomarker for the identification of acute kidney injury. Reliable clinical evaluations require a simple, robust test method for NGAL, and knowledge of specimen handling and specimen stability characteristics. We evaluated the performance of a new urine NGAL assay on the ARCHITECT analyzer. METHODS:Assay performance characteristics were evaluated using standard protocols. Urine specimen storage requirements were determined and biological variability was assessed in a self-declared apparently healthy population. RESULTS:Assay performance data showed good precision, sensitivity and lot-to-lot reproducibility. There was good short term 2-8 degrees C sample stability, however, long term storage samples must be kept at -70 degrees C or colder. The largest variance component in a biological variance study was within-day. CONCLUSIONS:The ARCHITECT NGAL assay proved to be a precise and reproducible assay for the determination of urine NGAL.
journal_name
Clin Biochemjournal_title
Clinical biochemistryauthors
Grenier FC,Ali S,Syed H,Workman R,Martens F,Liao M,Wang Y,Wong PYdoi
10.1016/j.clinbiochem.2009.12.008subject
Has Abstractpub_date
2010-04-01 00:00:00pages
615-20issue
6eissn
0009-9120issn
1873-2933pii
S0009-9120(09)00556-6journal_volume
43pub_type
杂志文章abstract::We present a systematic parametric method for resolving age-related reference intervals based on differential-polynomial regression analysis. Application of this method to plasma zinc concentrations in a childhood population results in a third degree polynomial expression from which two statistically independent age-r...
journal_title:Clinical biochemistry
pub_type: 杂志文章
doi:10.1016/s0009-9120(79)90056-0
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journal_title:Clinical biochemistry
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journal_title:Clinical biochemistry
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doi:10.1016/s0009-9120(00)00079-5
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journal_title:Clinical biochemistry
pub_type: 杂志文章
doi:10.1016/j.clinbiochem.2009.04.008
更新日期:2009-07-01 00:00:00
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journal_title:Clinical biochemistry
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doi:10.1016/j.clinbiochem.2010.05.009
更新日期:2010-08-01 00:00:00
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更新日期:2018-08-01 00:00:00
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journal_title:Clinical biochemistry
pub_type: 杂志文章
doi:10.1016/j.clinbiochem.2010.06.013
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journal_title:Clinical biochemistry
pub_type: 杂志文章
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更新日期:2018-03-01 00:00:00
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journal_title:Clinical biochemistry
pub_type: 杂志文章
doi:10.1016/0009-9120(95)02026-8
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pub_type: 杂志文章
doi:10.1016/j.clinbiochem.2007.09.016
更新日期:2008-01-01 00:00:00
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journal_title:Clinical biochemistry
pub_type: 杂志文章
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更新日期:2009-10-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:1990-02-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/s0009-9120(01)00199-0
更新日期:2001-07-01 00:00:00
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journal_title:Clinical biochemistry
pub_type: 杂志文章,评审
doi:10.1016/0009-9120(95)00022-2
更新日期:1995-08-01 00:00:00
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journal_title:Clinical biochemistry
pub_type: 杂志文章
doi:10.1016/j.clinbiochem.2007.07.014
更新日期:2007-11-01 00:00:00
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更新日期:1998-11-01 00:00:00
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journal_title:Clinical biochemistry
pub_type: 杂志文章,评审
doi:10.1016/j.clinbiochem.2004.08.009
更新日期:2004-12-01 00:00:00
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journal_title:Clinical biochemistry
pub_type: 杂志文章
doi:10.1016/j.clinbiochem.2008.04.026
更新日期:2008-10-01 00:00:00
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journal_title:Clinical biochemistry
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更新日期:2001-03-01 00:00:00
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journal_title:Clinical biochemistry
pub_type: 杂志文章
doi:10.1016/j.clinbiochem.2005.12.001
更新日期:2006-03-01 00:00:00
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journal_title:Clinical biochemistry
pub_type: 杂志文章
doi:10.1016/j.clinbiochem.2008.04.008
更新日期:2008-07-01 00:00:00
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journal_title:Clinical biochemistry
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更新日期:2018-09-01 00:00:00
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journal_title:Clinical biochemistry
pub_type: 杂志文章
doi:10.1016/j.clinbiochem.2005.06.009
更新日期:2005-10-01 00:00:00
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journal_title:Clinical biochemistry
pub_type: 杂志文章,评审
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更新日期:1992-04-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1016/0009-9120(90)90601-p
更新日期:1990-06-01 00:00:00