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Biochip arrays for the discovery of a biomarker surrogate in a phase I/II study assessing a novel anti-metastasis agent.

Abstract：

OBJECTIVE:Can biochip arrays identify which individuals with metastatic disease will respond to an anti-metastatic agent? DESIGN AND METHODS:Cytokine and cell adhesion arrays (Randox Ltd) were measured over 1 month in 9 research participants receiving CTCE-9908 in a Phase I/II study. RESULTS:Research participants with stable disease (n=2) had significantly higher soluble VCAM-1 as compared to those that progressed. DISCUSSION:VCAM-1 measurement early during CTCE-9908 treatment might be used as a surrogate for response.

journal_name

Clin Biochem

journal_title

Clinical biochemistry

authors

Kavsak PA,Henderson M,Moretto P,Hirte H,Evans K,Wong D,Korz W,Hotte SJ

doi

10.1016/j.clinbiochem.2009.04.008

subject

Has Abstract

pub_date

2009-07-01 00:00:00

pages

1162-5

issue

10-11

eissn

0009-9120

issn

1873-2933

pii

S0009-9120(09)00188-X

journal_volume

42

pub_type

杂志文章

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