Abstract:
:Sleep, waking, and EEG power spectra were investigated in rats with spinal 5,6-dihydroxytryptamine (5,6-DHT) lesions, following 20 mg/kg zimeldine or vehicle IP injections. 5,6-DHT selectively lesioned the descending serotonergic pathways. Lesion alone did not change sleep and waking stages compared to baseline, except for a reduction in REM sleep. Consistent with earlier findings, zimeldine in nonlesioned rats increased waking the first 2 h of recording. Zimeldine treatment in lesioned rats gave a significant additional 50% increase in waking the first 2 h and a corresponding decrease in total slow wave sleep, suggesting a potentiation of these effects. Zimeldine gave no significant changes in waking EEG power spectral density. Lesion gave a tendency to reduction between 4.0 and 15.5 Hz compared with baseline, and between 10.0 and 16.5 compared to the independent control group. In both comparisons, the combined treatment strengthened this effect, again suggesting a potentiating effect of lesion. In sleep, zimeldine reduced power over the whole spectrum (0.5-20.0 Hz), less in the lower frequencies than in the higher frequencies.
journal_name
Physiol Behavjournal_title
Physiology & behaviorauthors
Bjørkum AA,Neckelmann D,Bjorvatn B,Ursin Rdoi
10.1016/0031-9384(94)00370-ksubject
Has Abstractpub_date
1995-05-01 00:00:00pages
959-66issue
5eissn
0031-9384issn
1873-507Xpii
003193849400370Kjournal_volume
57pub_type
杂志文章abstract::Major histocompatibility complex (MHC) genes influence urinary odors (odortypes) of mice. That volatile odorants are involved is supported by the observation that odortype identity can be detected from a distance. Furthermore, chemical analyses of urines have revealed numerous volatile odorants that differ in relative...
journal_title:Physiology & behavior
pub_type: 杂志文章
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更新日期:2009-01-08 00:00:00
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journal_title:Physiology & behavior
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Physiology & behavior
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更新日期:1984-04-01 00:00:00
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journal_title:Physiology & behavior
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更新日期:2000-05-01 00:00:00
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journal_title:Physiology & behavior
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更新日期:2002-12-01 00:00:00
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journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(86)90042-9
更新日期:1986-01-01 00:00:00
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journal_title:Physiology & behavior
pub_type: 杂志文章
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更新日期:1984-08-01 00:00:00
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journal_title:Physiology & behavior
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更新日期:1989-11-01 00:00:00
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journal_title:Physiology & behavior
pub_type: 杂志文章
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更新日期:1997-02-01 00:00:00
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journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(91)90067-x
更新日期:1991-08-01 00:00:00
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journal_title:Physiology & behavior
pub_type: 杂志文章
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更新日期:1984-04-01 00:00:00
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journal_title:Physiology & behavior
pub_type: 杂志文章,随机对照试验
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更新日期:2014-04-10 00:00:00
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journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2014.12.045
更新日期:2015-03-01 00:00:00
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journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(87)90027-8
更新日期:1987-01-01 00:00:00
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journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(84)90136-7
更新日期:1984-02-01 00:00:00
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journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2007.12.021
更新日期:2008-03-18 00:00:00
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journal_title:Physiology & behavior
pub_type: 杂志文章
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更新日期:1992-01-01 00:00:00
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更新日期:2007-09-10 00:00:00
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journal_title:Physiology & behavior
pub_type: 杂志文章
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更新日期:1995-10-01 00:00:00
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journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(96)00107-2
更新日期:1996-09-01 00:00:00
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journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(92)90470-m
更新日期:1992-12-01 00:00:00
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journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(87)90006-0
更新日期:1987-01-01 00:00:00
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journal_title:Physiology & behavior
pub_type: 杂志文章
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更新日期:2020-10-01 00:00:00
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journal_title:Physiology & behavior
pub_type: 杂志文章,评审
doi:10.1016/j.physbeh.2006.01.028
更新日期:2006-08-30 00:00:00
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journal_title:Physiology & behavior
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更新日期:2021-03-15 00:00:00
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journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2007.09.009
更新日期:2008-01-28 00:00:00
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journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(96)00134-5
更新日期:1996-10-01 00:00:00