Lesion of descending 5-HT pathways increases zimeldine-induced waking in rats.

Abstract:

:Sleep, waking, and EEG power spectra were investigated in rats with spinal 5,6-dihydroxytryptamine (5,6-DHT) lesions, following 20 mg/kg zimeldine or vehicle IP injections. 5,6-DHT selectively lesioned the descending serotonergic pathways. Lesion alone did not change sleep and waking stages compared to baseline, except for a reduction in REM sleep. Consistent with earlier findings, zimeldine in nonlesioned rats increased waking the first 2 h of recording. Zimeldine treatment in lesioned rats gave a significant additional 50% increase in waking the first 2 h and a corresponding decrease in total slow wave sleep, suggesting a potentiation of these effects. Zimeldine gave no significant changes in waking EEG power spectral density. Lesion gave a tendency to reduction between 4.0 and 15.5 Hz compared with baseline, and between 10.0 and 16.5 compared to the independent control group. In both comparisons, the combined treatment strengthened this effect, again suggesting a potentiating effect of lesion. In sleep, zimeldine reduced power over the whole spectrum (0.5-20.0 Hz), less in the lower frequencies than in the higher frequencies.

journal_name

Physiol Behav

journal_title

Physiology & behavior

authors

Bjørkum AA,Neckelmann D,Bjorvatn B,Ursin R

doi

10.1016/0031-9384(94)00370-k

subject

Has Abstract

pub_date

1995-05-01 00:00:00

pages

959-66

issue

5

eissn

0031-9384

issn

1873-507X

pii

003193849400370K

journal_volume

57

pub_type

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