Abstract:
:Glucocorticoids have major effects on food intake, however, the underlying mechanisms are poorly understood. This article highlights data on the changes that occur when glucocorticoids are removed by adrenalectomy, and the effects of central and systemic administered glucocorticoids on feeding behavior in rats. Next, animal data on the interaction of glucocorticoids with insulin on intake of comfort foods are addressed and the hypothesis that glucocorticoids modify feeding behavior, whereas insulin modifies the choice of food is discussed. Finally a view is presented that hormonal and vagal signals generated when (comfort) food is consumed will affect the corticotropin-releasing factor (CRF) brain network important for the response to stress and the regulation of feeding. With a society, where stress is experienced daily and comfort food is found at every street corner, it will be vital to understand the interactions between the systems that react to stress and regulate feeding behavior to fight the obesity epidemic.
journal_name
Physiol Behavjournal_title
Physiology & behaviorauthors
la Fleur SEdoi
10.1016/j.physbeh.2006.01.028subject
Has Abstractpub_date
2006-08-30 00:00:00pages
110-4issue
1eissn
0031-9384issn
1873-507Xpii
S0031-9384(06)00053-9journal_volume
89pub_type
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