Lack of tolerance to contrast-reducing actions of chlordiazepoxide with repeated reward reductions.

Abstract:

:In each of eight cycles of repeated reward reduction, the performance of rats given brief access to 32% sucrose for 3 days, and then 4% sucrose for 2 days, was compared to rats that received 4% on all 5 days. Shifted rats consumed less than unshifted rats following each shift, with little evidence of diminution of negative contrast across the eight shifts. Acute administration of chlordiazepoxide (CDP, 8 mg/kg) on the second postshift day reduced contrast on each shift with no evidence of tolerance development to these anticontrast actions (Experiment 1a). Acute administration of CDP on the first postshift day had no effect on contrast through the first four shifts, but reliably reduced contrast on the following four shifts (Experiment 2a). There was tolerance to the sedative effects of CDP, as measured in an open field (Experiments 1b and 2b). The data thus show: a) that contrast is not lost with repeated shifts; b) no tolerance develops to the anticontrast actions of CDP and, instead, CDP gains anticontrast actions, in regard to initial contrast occurrence; c) but, concurrently, tolerance does develop to the sedative effects of CDP in an open field.

journal_name

Physiol Behav

journal_title

Physiology & behavior

authors

Flaherty CF,Clarke S,Coppotelli C

doi

10.1016/s0031-9384(96)80043-6

subject

Has Abstract

pub_date

1996-08-01 00:00:00

pages

645-52

issue

2

eissn

0031-9384

issn

1873-507X

pii

S0031-9384(96)80043-6

journal_volume

60

pub_type

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