Abstract:
:In each of eight cycles of repeated reward reduction, the performance of rats given brief access to 32% sucrose for 3 days, and then 4% sucrose for 2 days, was compared to rats that received 4% on all 5 days. Shifted rats consumed less than unshifted rats following each shift, with little evidence of diminution of negative contrast across the eight shifts. Acute administration of chlordiazepoxide (CDP, 8 mg/kg) on the second postshift day reduced contrast on each shift with no evidence of tolerance development to these anticontrast actions (Experiment 1a). Acute administration of CDP on the first postshift day had no effect on contrast through the first four shifts, but reliably reduced contrast on the following four shifts (Experiment 2a). There was tolerance to the sedative effects of CDP, as measured in an open field (Experiments 1b and 2b). The data thus show: a) that contrast is not lost with repeated shifts; b) no tolerance develops to the anticontrast actions of CDP and, instead, CDP gains anticontrast actions, in regard to initial contrast occurrence; c) but, concurrently, tolerance does develop to the sedative effects of CDP in an open field.
journal_name
Physiol Behavjournal_title
Physiology & behaviorauthors
Flaherty CF,Clarke S,Coppotelli Cdoi
10.1016/s0031-9384(96)80043-6subject
Has Abstractpub_date
1996-08-01 00:00:00pages
645-52issue
2eissn
0031-9384issn
1873-507Xpii
S0031-9384(96)80043-6journal_volume
60pub_type
杂志文章abstract::The need to obtain data from individual laboratory animals has forced many researchers to singly-house small animals. This is costly to the researcher and isolation can adversely affect animal physiology and behavior which in turn may threaten the validity and generalization of experiment results to humans. We assesse...
journal_title:Physiology & behavior
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journal_title:Physiology & behavior
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journal_title:Physiology & behavior
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journal_title:Physiology & behavior
pub_type: 杂志文章
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journal_title:Physiology & behavior
pub_type: 杂志文章
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journal_title:Physiology & behavior
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journal_title:Physiology & behavior
pub_type: 杂志文章
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doi:10.1016/0031-9384(89)90198-4
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pub_type: 杂志文章
doi:10.1016/0031-9384(90)90090-q
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journal_title:Physiology & behavior
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journal_title:Physiology & behavior
pub_type: 杂志文章
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journal_title:Physiology & behavior
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doi:10.1016/s0031-9384(99)00167-5
更新日期:1999-12-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2012-12-25 00:00:00
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journal_title:Physiology & behavior
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journal_title:Physiology & behavior
pub_type: 杂志文章
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journal_title:Physiology & behavior
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journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(82)90025-7
更新日期:1982-08-01 00:00:00
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journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/s0031-9384(98)00093-6
更新日期:1998-06-01 00:00:00
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journal_title:Physiology & behavior
pub_type: 杂志文章
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journal_title:Physiology & behavior
pub_type: 杂志文章
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更新日期:1992-06-01 00:00:00
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journal_title:Physiology & behavior
pub_type: 杂志文章
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