Abstract:
:Rats selectively display conditioned gaping reactions when re-exposed to flavours previously paired with nausea-inducing treatments and drugs that reduce nausea also reduce these reactions, suggesting that they represent a model of nausea-induced behavior in rats. However, these reactions rely upon learning, they are not unconditional malaise-induced reactions. Here we compared the effectiveness of the anti-nausea drug, ondansetron (OND) to interfere with the establishment of conditioned gaping reactions and the unconditional malaise-induced reaction of lying on belly (LOB). Pretreatment with OND significantly reduced both LiCl-induced LOB and conditioned gaping reactions, without modifying conditioned taste avoidance. The frequency of gaping and duration of LOB were highly correlated. These results provide additional support for the validity of the conditioned gaping model as a rodent model of nausea-induced behavior.
journal_name
Physiol Behavjournal_title
Physiology & behaviorauthors
Tuerke KJ,Winters BD,Parker LAdoi
10.1016/j.physbeh.2011.10.017subject
Has Abstractpub_date
2012-02-01 00:00:00pages
856-60issue
3eissn
0031-9384issn
1873-507Xpii
S0031-9384(11)00505-1journal_volume
105pub_type
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journal_title:Physiology & behavior
pub_type: 杂志文章,评审
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journal_title:Physiology & behavior
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