Abstract：
:Behavioural and hypothalamic-pituitary-adrenal (HPA) axis responses were investigated in farm mink (Mustela vison) selected for either confident or fearful behaviour for nine generations. Two groups of 2-year-old confident (n=12) and fearful (n=12) female mink were given the serotonin (5-HT) 1A receptor agonist buspirone (1.25 mg/kg/day), whereas two other groups of 2-year-old confident (n=12) and fearful (n=12) female mink were given saline, continuously for 5 weeks via osmotic minipumps. Behavioural reactions towards a novel object and towards humans were tested after 19-25 days, and HPA axis reactivity [adrenocorticotropic hormone (ACTH), cortisol] was measured after 28-31 days of treatment. Confident mink were more exploratory than fearful mink towards humans and a novel object. Confident mink spent more time in contact with the object than did fearful mink during saline-but not during buspirone-treatment. buspirone increased approach-withdrawal conflict behaviour towards a object in fearful mink only. The chronic dose of buspirone did not reduce fear towards humans and did not affect latencies to reaction, number of contacts, number and duration of manipulations, and stereotypic behaviour in a Novel Object test. Different HPA axis responses have emerged between confident and fearful mink, together with a different degree of fear-related behaviour. Fearful mink have a higher cortisol combined with a lower ACTH secretion than confident mink in response to capture and blood sampling. The central serotonergic system may be involved, and even though the precise underlying mechanisms are presently unknown, treatment with a 5-HT(1A) receptor agonist reduces the difference between confident and fearful mink in HPA axis reactivity.
journal_name
Physiol Behavjournal_title
Physiology & behaviorauthors
Malmkvist J,Hansen SW,Damgaard BMdoi
10.1016/s0031-9384(02)00964-2subject
Has Abstractpub_date
2003-02-01 00:00:00pages
229-40issue
2eissn
0031-9384issn
1873-507Xpii
S0031938402009642journal_volume
78pub_type
杂志文章abstract：:Wistar rats were exposed to 24-h cycles of sinusoidal varying light intensity at various amplitudes (A) and mean intensity (I) levels. The cycle minimum was at least 0.1 lux. Food approaches and wheel running activity were continuously recorded. Entrainment was observed to light cycles with amplitudes as low as 2 lux....
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(91)90588-f
更新日期：1991-12-01 00:00:00
abstract：:Beta,beta'-iminodipropionitrile (IDPN)-induced muscle weakness in rats is a model for motorneuropathy diseases. The effects of oral administration of branched-chain amino acids on the progression of muscle weakness and muscle atrophy induced by the administration of IDPN in the drinking water, were investigated in thi...
journal_title：Physiology & behavior
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更新日期：1997-09-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(90)90064-b
更新日期：1990-01-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
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更新日期：2015-02-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2015.03.014
更新日期：2015-05-15 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
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更新日期：2004-09-15 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
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更新日期：1986-01-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章,评审
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更新日期：2008-04-22 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(93)90083-r
更新日期：1993-10-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
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更新日期：1994-05-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
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更新日期：2018-02-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(90)90158-z
更新日期：1990-02-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2016.06.007
更新日期：2016-10-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(90)90068-f
更新日期：1990-04-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(87)90040-0
更新日期：1987-01-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：1990-01-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2017.11.024
更新日期：2018-02-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(86)90234-9
更新日期：1986-01-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
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更新日期：1983-06-01 00:00:00
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journal_title：Physiology & behavior
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更新日期：2009-03-02 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
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更新日期：1996-01-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：
更新日期：1983-11-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/0031-9384(91)90535-v
更新日期：1991-09-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
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更新日期：1987-01-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2007.11.002
更新日期：2008-02-27 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
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更新日期：1999-11-01 00:00:00
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更新日期：2020-03-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(93)90120-5
更新日期：1993-08-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.physbeh.2007.06.008
更新日期：2007-12-05 00:00:00
