Abstract：
:Drug addiction is a chronic disorder resulted from complex interaction of genetic, environmental, and developmental factors. Epigenetic mechanisms play an important role in the development and maintenance of addiction and also memory formation in the brain. We have examined passive avoidance memory and morphine conditioned place preference (CPP) in the offspring of male and/or female rats with a history of adulthood morphine consumption. Adult male and female animals received chronic oral morphine for 21days and then were maintained drug free for 10days. After that, they were let to mate with either an abstinent or control rat. Male offspring's memory was evaluated by step through test. Besides, rewarding effects of morphine were checked with CCP paradigm. Offspring of abstinent animals showed significant memory impairment compared to the control group which was more prominent in the offspring of abstinent females. Conditioning results showed that administration of a high dose of morphine (10mg/kg) that could significantly induce CPP in control rats, was not able to induce similar results in the offspring of morphine abstinent parents; and CPP was much more prominent when it was induced in the offspring of morphine exposed females compared to the progeny of morphine exposed males. It is concluded that parental morphine consumption in adulthood even before mating has destructive effects on memory state of the male offspring and also leads to tolerance to the rewarding effects of morphine. These effects are greater when the morphine consumer parent is the female one.
journal_name
Physiol Behavjournal_title
Physiology & behaviorauthors
Akbarabadi A,Niknamfar S,Vousooghi N,Sadat-Shirazi MS,Toolee H,Zarrindast MRdoi
10.1016/j.physbeh.2017.11.024subject
Has Abstractpub_date
2018-02-01 00:00:00pages
143-149eissn
0031-9384issn
1873-507Xpii
S0031-9384(17)30415-8journal_volume
184pub_type
杂志文章abstract：:The amphibian tetradecapeptide bombesin (BN) decreases food intake in both humans and animals. Studies have typically examined the effects of BN on scheduled meals in deprived subjects. To investigate the properties of this peptide under more naturalistic conditions, we examined the effects of BN in spontaneously feed...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(95)02136-1
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pub_type： 杂志文章,评审
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journal_title：Physiology & behavior
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doi：10.1016/0031-9384(86)90327-6
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journal_title：Physiology & behavior
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journal_title：Physiology & behavior
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journal_title：Physiology & behavior
pub_type： 杂志文章
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journal_title：Physiology & behavior
pub_type： 临床试验,杂志文章
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journal_title：Physiology & behavior
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更新日期：2004-12-15 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
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更新日期：2015-02-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/s0031-9384(96)80043-6
更新日期：1996-08-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章,评审
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2007.03.014
更新日期：2007-06-08 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2018.12.010
更新日期：2019-03-15 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/s0031-9384(98)00295-9
更新日期：1999-05-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章,meta分析
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journal_title：Physiology & behavior
pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：Physiology & behavior
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更新日期：2002-12-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
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更新日期：2017-01-01 00:00:00
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journal_title：Physiology & behavior
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journal_title：Physiology & behavior
pub_type： 杂志文章
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journal_title：Physiology & behavior
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更新日期：1986-01-01 00:00:00
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pub_type： 杂志文章
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journal_title：Physiology & behavior
pub_type： 杂志文章
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journal_title：Physiology & behavior
pub_type： 杂志文章
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