Sham drinking in rats: osmotic and volumetric manipulations.

Abstract:

:Male rats, fitted with indwelling gastric fistulas, were tested with either a closed fistula (normal drinking) or an open fistula (sham drinking) following either intracellular dehydration (with NaCl), extracellular dehydration (with PEG), or the combination of the two stimuli. In normal drinking tests, the combined stimulus induced an intake of water that was the sum of the individual effects. In sham-drinking tests, both NaCl- and PEG-treated rats drank up to twice that of their normal drinking counterparts, but those given NaCl + PEG showed no such increase. Various body fluid measurements confirmed the persistence of the respective dehydration states at the end of sham-drinking sessions. The relatively poor or absent sham drinks after these stimuli are contrasted with vigorous sham drinking following fluid deprivation. In a second experiment, sham drinking following NaCl injections did not improve with repeated testing, but intake after intravenous infusion of NaCl did show some increase but was still modest and slow compared with that after fluid deprivation.

journal_name

Physiol Behav

journal_title

Physiology & behavior

authors

Salisbury JJ,Rowland NE

doi

10.1016/0031-9384(90)90068-f

subject

Has Abstract

pub_date

1990-04-01 00:00:00

pages

625-30

issue

4

eissn

0031-9384

issn

1873-507X

pii

0031-9384(90)90068-F

journal_volume

47

pub_type

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