Abstract：
:Neonatal monosodium glutamate (MSG) treatment has been associated with dysfunctions in stress responses. Therefore, the present study aimed at examining the acoustic startle response (ASR) in MSG-treated rats and the effects of fetal neural transplantation. Male and female rats were given MSG (4 mg/g) or saline on alternate days from days 2-10 after birth. To determine whether fetal transplants could reverse behavioral impairments observed in MSG-treated rats, at 12 days of age MSG-treated rats received either arcuate nucleus (AN), cortical fetal grafts, or sham surgery into the third ventricle. ASR amplitude was measured at 35-40 days of age, and again in adulthood. MSG produced the expected decrease in the density of hypothalamic neuropeptide Y (NPY) and tyrosine hydroxylase (TH) in the AN area. Corticotropin-releasing factor (CRF) neurons/fibers were not affected by MSG. Pituitary atrophy was observed in all MSG rats. We report a permanent increase in the amplitude and reduction in short-term habituation of ASR in all MSG-treated rats. No effect was observed on long-term habituation in male rats. Cortical, but not AN tissue significantly reduced the magnitude of ASR in MSG animals. The results are discussed in terms of the central pathways mediating ASR, in particular hypothalamo-amygdala connections. It is considered that nonspecific factors mediate recovery produced by cortical tissue grafts, as observed in other models of neural transplantation.
journal_name
Physiol Behavjournal_title
Physiology & behaviorauthors
Yang FC,Connor J,Patel A,Doat MM,Romero MTdoi
10.1016/s0031-9384(99)00256-5subject
Has Abstractpub_date
2000-05-01 00:00:00pages
333-44issue
3eissn
0031-9384issn
1873-507Xpii
S0031-9384(99)00256-5journal_volume
69pub_type
杂志文章abstract：:The discovery of the molecular mechanisms underlying the circadian clock, which functions in virtually every cell throughout the body to coordinate biological processes to anticipate and better adapt to daily rhythmic changes in the environment, is one of the major biomedical breakthroughs in the 20th century. Twenty ...
journal_title：Physiology & behavior
pub_type： 杂志文章,评审
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更新日期：2018-09-01 00:00:00
abstract：:Rats exposed to a relatively high dose (7.5 g/kg body weight) of alcohol on either the fifth or tenth postnatal day of age have been reported to have long-lasting deficits in spatial learning ability as tested on the Morris water maze task. The question arises concerning the level of alcohol required to achieve this e...
journal_title：Physiology & behavior
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更新日期：1998-01-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
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journal_title：Physiology & behavior
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journal_title：Physiology & behavior
pub_type： 临床试验,杂志文章
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更新日期：1998-08-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
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更新日期：1992-11-01 00:00:00
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journal_title：Physiology & behavior
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更新日期：2017-10-01 00:00:00
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pub_type： 杂志文章
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更新日期：1984-02-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2005.12.014
更新日期：2006-08-30 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2007.12.021
更新日期：2008-03-18 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(87)90164-8
更新日期：1987-01-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/0031-9384(91)90489-b
更新日期：1991-07-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(92)90078-g
更新日期：1992-05-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2016.01.002
更新日期：2016-03-15 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章,评审
doi：10.1016/j.physbeh.2016.11.021
更新日期：2017-09-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/s0031-9384(98)00207-8
更新日期：1998-12-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 临床试验,杂志文章
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(92)90108-e
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journal_title：Physiology & behavior
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更新日期：1986-01-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
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更新日期：1975-08-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：2002-11-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
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更新日期：2019-11-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.physbeh.2019.112734
更新日期：2020-02-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
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更新日期：1988-01-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2009.09.018
更新日期：2009-12-07 00:00:00
abstract：:Cardiovascular disease is the leading cause of death worldwide and hypertension is the most common risk factor for death. Although many anti-hypertensive pharmacotherapies are approved for use in the United States, rates of hypertension have increased over the past decade. This review article summarizes a presentation...
journal_title：Physiology & behavior
pub_type： 杂志文章,评审
doi：10.1016/j.physbeh.2016.01.020
更新日期：2016-08-01 00:00:00
abstract：:Rats were concurrently exposed to a sustained avoidance/escape (SAE) procedure and a procedure for assessing demand for food. In the sustained SAE procedure, signalled shock avoidance/escape trials were presented at varying intervals averaging five minutes. The shock could be avoided by pulling on a ceiling chain earl...
journal_title：Physiology & behavior
pub_type： 杂志文章
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更新日期：1991-03-01 00:00:00
