Abstract：
BACKGROUND:The development of body weight is determined by different factors, namely genetic, behavioral, parental and physiological. OBJECTIVE:To investigate whether genetic, behavioral, parental and physiological factors are involved and the extent of involvement in the development of body weight at ages 12 and 13 y in a Dutch children cohort. METHODS:In a Dutch cohort of 94 children at ages 12 and 13 y, we determined anthropometric measurements, body composition, leptin concentrations, TFEQ scores, physical activity, as well as 3 polymorphisms, and in the parents we determined anthropometric measurements and TFEQ scores. RESULTS:11% of the children in the cohort were classified as overweight. The genotype frequency distributions of the PPARy2, GRL and CNTF genes at ages 12 and 13 y were not significantly different for the overweight children compared to the lean children. Overweight children showed higher dietary restraint and disinhibition scores. Overweight children's parents had a higher BMI, dietary restraint and disinhibition scores, compared to lean children's parents. A peak in leptin concentrations between 7 and 13 y was shown at 12 y. In lean boys, the decrease in leptin concentrations between 12 and 13 y was related to an increase in fat free mass. At the age of 12 y predominantly the physiological factors were predictors for body weight, and at the age of 13 y both the physiological and behavioral factors were predictors for body weight. CONCLUSION:We conclude from this longitudinal study, that leptin appeared to play an important role in the development of body weight during puberty, in addition to behavioral and parental factors.
journal_name
Physiol Behavjournal_title
Physiology & behaviorauthors
Rutters F,Nieuwenhuizen AG,Vogels N,Bouwman F,Mariman E,Westerterp-Plantenga MSdoi
10.1016/j.physbeh.2007.12.021subject
Has Abstractpub_date
2008-03-18 00:00:00pages
967-74issue
4-5eissn
0031-9384issn
1873-507Xpii
S0031-9384(07)00507-0journal_volume
93pub_type
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journal_title：Physiology & behavior
pub_type： 杂志文章
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更新日期：1990-02-01 00:00:00
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journal_title：Physiology & behavior
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更新日期：2008-03-18 00:00:00
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pub_type： 杂志文章
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更新日期：1995-12-01 00:00:00
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pub_type： 杂志文章
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pub_type： 临床试验,杂志文章
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更新日期：2006-07-30 00:00:00
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更新日期：2016-09-01 00:00:00
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更新日期：2004-11-15 00:00:00
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pub_type： 杂志文章
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更新日期：1976-12-01 00:00:00
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