Altered preferences for sucrose, sodium chloride, urea and hydrochloric acid solutions in an animal model of cholestatic liver disease.

Abstract:

:Preferences for sucrose, sodium chloride (NaCl), urea and hydrochloric acid (HCl) solutions (representing sweet, salty, bitter and sour stimuli) were examined in rats with bile duct ligation using 24-hr two-bottle choice tests. Preferences in bile duct ligated rats for sucrose and NaCl solutions were decreased relative to control animals in the initial stages following ligation (Days 1-5) and then increased in the later stages (Days 11-20). Preferences for both HCl and urea solutions were decreased briefly compared to control animals but showed no consistent pattern. The results provide the first demonstration for altered ingestive behavior in an animal model of liver disease and suggest that the bile duct ligated rat may be useful in studying mechanisms of chemosensory disturbances in human liver disease.

journal_name

Physiol Behav

journal_title

Physiology & behavior

authors

Deems RO,Friedman MI

doi

10.1016/0031-9384(88)90105-9

subject

Has Abstract

pub_date

1988-01-01 00:00:00

pages

111-4

issue

1

eissn

0031-9384

issn

1873-507X

pii

0031-9384(88)90105-9

journal_volume

43

pub_type

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