Abstract:
:Harmaline (HA) is a beta-carboline commonly known to provoke motor alterations through activation of cells in the inferior olive. In addition, this pharmacological agent also induces cognitive disturbances such as motor and spatial learning impairments. In order to complete and extend these data, we examined the effects of this drug on state anxiety in mice, employing elevated plus maze test. We report here that lower doses of harmaline (5-10 mg/kg) have anxiogenic since higher doses (20 mg/kg) have anxiolytic-like properties. Overall pattern of our behavioral results provides evidence that harmaline also acts on emotional reactivity in mice by influencing their decision making when placed in an anxiogenic situation.
journal_name
Physiol Behavjournal_title
Physiology & behaviorauthors
Hilber P,Chapillon Pdoi
10.1016/j.physbeh.2005.07.006subject
Has Abstractpub_date
2005-09-15 00:00:00pages
164-7issue
1-2eissn
0031-9384issn
1873-507Xpii
S0031-9384(05)00269-6journal_volume
86pub_type
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