Evaluation of functional asymmetry in rats with dose-dependent lesions of dopaminergic nigrostriatal system using elevated body swing test.


:Although drug-induced rotational behavior has conventionally been used for the assessment of functional asymmetry in 6-hydroxydopamine (OHDA)-lesioned rats, a pure behavioral test that can evaluate animals with dose-dependent lesions of the dopaminergic nigrostriatal system in a drug-free state may better reflect a more natural response following lesion. In this study, elevated body swing test (EBST) was used for evaluation of rats with varying lesions of the dopaminergic nigrostriatal system. For this purpose, rats received intrastriatal injection of 8 (L1), 12 (L2), 16 (L3), and 20 (L4) microg of the neurotoxin 6-OHDA (dissolved in 5 microl of saline-ascorbate). Apomorphine-induced rotational and drug-free elevated body swing behaviors were evaluated before and at different time points after the experiment. The results showed that although there is a significant trend for contralateral rotations and drug-free swings in lesioned rats as compared to sham-operated group, however, there were no significant differences between the L1 and L2 and between the L3 and L4 groups regarding EBST. Therefore, EBST may be valuable for behavioral analysis of rats with mild and/or severe damage of the dopaminergic nigrostriatal system.


Physiol Behav


Physiology & behavior


Baluchnejadmojarad T,Roghani M




Has Abstract


2004-09-15 00:00:00














  • Detection of very complex taste mixtures: generous integration across constituent compounds.

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    journal_title:Physiology & behavior

    pub_type: 杂志文章


    authors: Stevens JC

    更新日期:1997-11-01 00:00:00

  • Aversive viscerally referred states and thirst accompanying the sating of hunger motivation by rapid digestion of glucosaccharides.

    abstract::Associative conditioning of satiety indicates that concentrated maltodextrin (cMD) may induce a mildly aversive visceral signal within 20 min of its ingestion, as well as satiating normally. Individuals' awareness of this adverse state was tested on ratings of statistically distinct descriptions of factors liable to s...

    journal_title:Physiology & behavior

    pub_type: 杂志文章


    authors: Booth DA,O'Leary G,Li L,Higgs S

    更新日期:2011-03-01 00:00:00

  • Mate choice could be random in female rats (Rattus norvegicus).

    abstract::Female mate choice is often investigated in terms of reproductive success in order to understand how male characteristics contribute to sexual attractiveness. Previous studies have found that females rats prefer mating with their first encounter rather than males visited subsequently, suggesting that the rewarding val...

    journal_title:Physiology & behavior

    pub_type: 杂志文章


    authors: Le Moëne O,Snoeren EM

    更新日期:2018-02-01 00:00:00

  • Effects of repeated stress on plasma arginine levels in young and old rats.

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    journal_title:Physiology & behavior

    pub_type: 杂志文章


    authors: Milakofsky L,Harris N,Vogel WH

    更新日期:1993-10-01 00:00:00

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    journal_title:Physiology & behavior

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    authors: Sabban EL,Maharjan S,Nostramo R,Serova LI

    更新日期:2010-02-09 00:00:00

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    journal_title:Physiology & behavior

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    authors: Wu FM,Noble RG

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    journal_title:Physiology & behavior

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    authors: Sclafani A,Gale SK,Springer D

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    journal_title:Physiology & behavior

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    authors: Pearlman C

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  • Eating rate during a fixed-portion meal does not affect postprandial appetite and gut peptides or energy intake during a subsequent meal.

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    authors: Rosenwasser AM,Pelchat RJ,Adler NT

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  • Prenatal stress alters maternal aggression in mice.

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    journal_title:Physiology & behavior

    pub_type: 杂志文章


    authors: Kinsley C,Svare B

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    pub_type: 临床试验,杂志文章,随机对照试验


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    pub_type: 杂志文章


    authors: Bulbulian R,Bitters D

    更新日期:1996-10-01 00:00:00

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    authors: Shibata M,Hori T,Kiyohara T,Nakashima T,Osaka T

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    journal_title:Physiology & behavior

    pub_type: 杂志文章


    authors: Pivik RT,Bylsma FW,Cooper P

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    journal_title:Physiology & behavior

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    journal_title:Physiology & behavior

    pub_type: 杂志文章


    authors: Carbonaro DA,Friend TH,Dellmeier GR,Nuti LC

    更新日期:1992-02-01 00:00:00