Antipsychotic drug and body weight set-point.

Abstract:

OBJECTIVE:Antipsychotic (AP) drugs frequently induce weight gain. The present study aimed at exploring a potential association between antipsychotic-induced weight gain and delayed negative alliesthesia for sweet stimuli. RESEARCH METHODS AND PROCEDURES:The study aimed at recruiting patients undergoing AP treatment, half of them with stable weight and the other half with documented weight gain. Negative alliesthesia to sweet stimuli was assessed through a specific procedure. RESULTS:A multivariate regression of the data obtained from the entire sample was performed to establish the relationship between alliesthesia dependent variables and weight gain as a predictor. The overall F statistic shows that there was a significant association between delayed negative alliesthesia for sweet stimuli and weight gain. CONCLUSION:Atypical antipsychotic drug-induced weight gain seems to result from a raised body weight set-point.

journal_name

Physiol Behav

journal_title

Physiology & behavior

authors

Khazaal Y,Chatton A,Claeys F,Ribordy F,Zullino D,Cabanac M

doi

10.1016/j.physbeh.2008.05.013

subject

Has Abstract

pub_date

2008-09-03 00:00:00

pages

157-60

issue

1-2

eissn

0031-9384

issn

1873-507X

pii

S0031-9384(08)00161-3

journal_volume

95

pub_type

临床试验,杂志文章
  • Nutrition, weight gain and eating behavior in pregnancy: a review of experimental evidence for long-term effects on the risk of obesity in offspring.

    abstract::Obesity has reached near epidemic proportions in the developed world. As reproductive age women are a part of this trend, the effect of maternal obesity on the developing fetus must be investigated. In this review, we evaluated the experimental evidence relating maternal nutritional status and eating behavior before a...

    journal_title:Physiology & behavior

    pub_type: 杂志文章,评审

    doi:10.1016/j.physbeh.2012.04.014

    authors: Sen S,Carpenter AH,Hochstadt J,Huddleston JY,Kustanovich V,Reynolds AA,Roberts S

    更新日期:2012-08-20 00:00:00

  • Assessment of sucrose and ethanol reinforcement: the across-session breakpoint procedure.

    abstract::We have demonstrated previously that the use of an across-session progressive ratio procedure yields breakpoint values for 10% ethanol (10E) that are stable and comparable to those measured for other drugs of abuse [Alcohol. Clin. Exp. Res. 23 (1999) 1580]. The aims of the present experiment were twofold: (1). to dete...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/s0031-9384(02)00963-0

    authors: Czachowski CL,Legg BH,Samson HH

    更新日期:2003-01-01 00:00:00

  • Fat, carbohydrate and protein by oral gavage in the rat can be equally effective for satiation.

    abstract::This study aimed to determine the relative efficacy of the macronutrients, protein, fat and carbohydrate to induce satiation and satiety in rats in relation to macronutrient activation of neurons in the nucleus of the solitary tract (NTS). Male Sprague Dawley rats were schedule-fed twice a day for 2 h, receiving 100% ...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2019.04.022

    authors: Cassie N,Anderson R,Wilson D,Mercer JG,Barrett P

    更新日期:2019-08-01 00:00:00

  • The effects of lithium upon drinking in the pigeon and rat.

    abstract::Single administrations of LiCl in fluid deprived pigeons produced immediate and sustained drinking which was (a) significantly greater than in NaCl-injected birds, (b) a function of the dosage of lithium, and (c) persistent for several days following the highest dosage used. Experiment 2 employed the same procedures t...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(79)90191-4

    authors: Westbrook RF,Hardy WT,Faulks I

    更新日期:1979-11-01 00:00:00

  • Naloxone reversal of stress-induced suppression of LH release in the common marmoset.

    abstract::There is considerable evidence suggesting that endogenous opioid peptides (EOP) might play a role in the defensive response to stressful stimuli. The stress associated with receipt of aggression from a female conspecific and physical restraint for collection of serial blood samples (at 10-min intervals) resulted in a ...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(89)90241-2

    authors: O'Byrne KT,Lunn SF,Dixson AF

    更新日期:1989-05-01 00:00:00

  • Metabolic and vascular pattern in medial pterygoid muscle is altered by chronic stress in an animal model of hypodontia.

    abstract::Psychological stress is an important perpetuating, worsening and risk factor for temporomandibular disorders of muscular or articular origin. Occlusion instability, by the way, is considered a risk factor of this pathology and can be reproduced in some experimental animal models. The exact physiologic mechanism underl...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2017.12.026

    authors: Fernández RAR,Pereira YCL,Iyomasa DM,Calzzani RA,Leite-Panissi CRA,Iyomasa MM,Nascimento GC

    更新日期:2018-03-01 00:00:00

  • Olfactory environment and early mating behavior in the cyclic female rat.

    abstract::The objectives of this study were to examine the effects of olfactory cues from the male and of olfactory bulb removal on early mating behavior in sexually inexperienced diestrous female rats primed with estrogen. Four-day cyclic rats isolated from the male were given either 2.5 micrograms or 10 micrograms estradiol b...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(86)90159-9

    authors: Antz-Vaxman M,Aron C

    更新日期:1986-01-01 00:00:00

  • Conditioned inhibition of antibody response and CD4 positive cells.

    abstract::Animals were assigned to three experimental groups, conditioned (cyclophosphamide-glucose treatment; C group), non-conditioned (cyclophosphamide-commercial pellet treatment; NC group) and placebo (saline solution-glucose treatment; P group). The three groups were injected intraperitoneally (i.p.) with sheep red blood ...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/s0031-9384(98)00093-6

    authors: Napolitano F,De Rosa G,Grasso F,Migliori G,Bordi A

    更新日期:1998-06-01 00:00:00

  • Social defeat-induced contextual conditioning differentially imprints behavioral and adrenal reactivity: a time-course study in the rat.

    abstract::The present experiments were based on the rat resident-intruder paradigm and aimed at better understanding the long-term conditioning properties of this social stress model. Intruders were exposed to aggressive conspecifics residents. During 3 daily encounters, intruders were either defeated or threatened by residents...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2007.05.063

    authors: Razzoli M,Carboni L,Guidi A,Gerrard P,Arban R

    更新日期:2007-11-23 00:00:00

  • Protective effect of low dose caffeine on psychological stress and cognitive function.

    abstract:INTRODUCTION:Caffeine is an adrenergic antagonist that enhances neuronal activity. Psychological stress depresses cognitive function. AIM:To investigate the effects of acute and chronic low dose caffeine on anxiety-like behavior and cognitive functions of acute or chronic psychological stressed rats. MATERIAL-METHOD:...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2016.10.010

    authors: Kasimay Cakir O,Ellek N,Salehin N,Hamamcı R,Keleş H,Kayalı DG,Akakın D,Yüksel M,Özbeyli D

    更新日期:2017-01-01 00:00:00

  • Postprandial sleep and thermogenesis in normal men.

    abstract::Twelve normal male subjects were given low- (16.77 kj/kg) and high- (54.49 kj/kg) calorie liquid carbohydrate lunch meals on 4 days, during which measures of sleep EEG, thermogenesis (heat production), core body temperature, and skin surface temperature were obtained. On 2 days subjects were required to remain awake, ...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(92)90267-6

    authors: Zammit GK,Ackerman SH,Shindledecker R,Fauci M,Smith GP

    更新日期:1992-08-01 00:00:00

  • Early overnutrition alters synaptic signaling and induces leptin resistance in arcuate proopiomelanocortin neurons.

    abstract::Early overnutrition disrupts leptin sensitivity and the development of hypothalamic pathways involved in the regulation of metabolism and feeding behavior. While previous studies have largely focused on the development of neuronal projections, few studies have examined the impact of early nutrition on hypothalamic syn...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2019.04.002

    authors: Roberts BL,Bennett CM,Carroll JM,Lindsley SR,Kievit P

    更新日期:2019-07-01 00:00:00

  • The cephalic phase insulin response to nutritive and low-calorie sweeteners in solid and beverage form.

    abstract::The purpose of the study was to examine the role of the cephalic phase insulin response (CPIR) following exposure to nutritive and low-calorie sweeteners in solid and beverage form in overweight and obese adults. In addition, the role of learning on the CPIR to nutritive and low-calorie sweetener exposure was tested. ...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2017.09.009

    authors: Dhillon J,Lee JY,Mattes RD

    更新日期:2017-11-01 00:00:00

  • Aromatase as a cellular marker of testosterone action in the preoptic area.

    abstract::We recently showed, using a new immunocytochemical technique, that aromatase-immunoreactive neurons are a specific marker for the sexually dimorphic medial preoptic nucleus (POM) in quail and that the number of these immunoreactive cells is markedly increased by a systemic treatment with testosterone (T). Since the PO...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(92)90158-x

    authors: Balthazart J,Surlemont C,Harada N

    更新日期:1992-02-01 00:00:00

  • Behavioral responses of CD-1 mice to conspecific and heterospecific blood odors and to a blood odor component.

    abstract::The odor of blood may have both aversive and attractive properties for mammals, depending on the species of the odor donor and the species perceiving the odor. To better understand the informational content of blood odor for a prey species we assessed behavioral responses of male CD-1 mice (n=60) to the odor of blood ...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2017.12.006

    authors: Lahger C,Laska M

    更新日期:2018-02-01 00:00:00

  • Female mice seek refuge from castrated males, but not intact or vasectomized males, mitigating a socially-induced glucocorticoid response.

    abstract::Sexual conflict may be manifested during social interactions, shaping the costs of reproduction in sexually reproducing species. This conflict, and the physical necessity of intromission, can intensify the already costly nature of reproduction for female mammals. To identify and partition the costs that males inflict ...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2019.112678

    authors: Gale TJ,Garratt M,Brooks RC

    更新日期:2019-11-01 00:00:00

  • Effects of different types of isocaloric parenteral nutrients on food intake and metabolic concomitants.

    abstract::Whether spontaneous food intake (SFI) is controlled by infused nutrient type or its caloric content, irrespective of nutrient type, was investigated. Rats were infused for 4 days with isocaloric solutions of different nutrient type but sharing the same intermediary metabolic oxidative pathway, providing 25% of daily c...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(95)00028-h

    authors: Bodoky G,Meguid MM,Yang ZJ,Laviano A

    更新日期:1995-07-01 00:00:00

  • "The addition of naltrexone alters cerebral glucose uptake following acute forced swimming".

    abstract::Endogenous opioid release has been linked to exercise. We investigated if opioid blockade following forced swimming, a common model of rodent exercise, influenced cerebral glucose metabolism in mice. PET scan was used to assess the uptake of Fludeoxyglucose (FDG-18), a marker of cerebral glucose metabolism in 19 regio...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2020.113199

    authors: Qadiri Q,York H,Muth BJ,Longoria CR,Campbell SC,Guers JJ

    更新日期:2021-01-01 00:00:00

  • Preconceptual paternal environmental stimulation alters behavioural phenotypes and adaptive responses intergenerationally in Swiss mice.

    abstract::Experimental research has recently revealed that paternal environmental conditions can influence the offspring phenotype through epigenetic mechanisms. However, it is unclear whether these effects impact adaptive responses in the offspring. Environmental enrichment (EE) is a well-established paradigm that promotes neu...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2020.112968

    authors: Hoffmann LB,Rae M,Marianno P,Pang TY,Hannan AJ,Camarini R

    更新日期:2020-09-01 00:00:00

  • Central versus peripheral effects on temperature preference and body temperature following alteration of 5-HT in maturing mice.

    abstract::Experiments were designed to distinguish between central and peripheral effects on temperature preference and body temperature of drugs injected intraperitoneally (IP) in infant mice ranging in age from 3 to 10 days postpartum. These compared a drug restricted to the periphery ("peripheral" drug) with a drug of simila...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(89)90257-6

    authors: Goodrich C,Lechner R,Slone W

    更新日期:1989-08-01 00:00:00

  • Repeated gastric distension alters food intake and neuroendocrine profiles in rats.

    abstract::The consumption of a large food bolus leads to stomach distension. Gastric distension potently signals the termination of a meal by stimulating gastric mechanoreceptors and activating neuroendocrine circuitry. The ability to terminate a meal is altered in disorders such as bulimia nervosa (BN), binge-eating disorder (...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2011.11.006

    authors: Hargrave SL,Kinzig KP

    更新日期:2012-02-28 00:00:00

  • Baroreceptor involvement in classically conditioned heart rate responses of restrained rats.

    abstract::A group (N = 8) of restrained, baroreceptor denervated rats and a sham-operated-control group (n = 8) received discriminated classical conditioning consisting of 30 reinforced trials in which a CS+ was paired with an electric shock US and 30 non-reinforced trials in which a different CS (CS-) was presented alone. The ...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(84)90009-x

    authors: Hatton DC,Foutz SR,Fitzgerald RD

    更新日期:1984-07-01 00:00:00

  • Medial prefrontal cortex oxytocin-opioid receptors interaction in spatial memory processing in rats.

    abstract::Medial prefrontal cortex (mPFC), a forebrain structure, is involved in many brain functions such as learning and memory. In the present study, the effect of intra-mPFC microinjection of oxytocin, atosiban, morphine and naloxone was investigated on memory processing. Two guide cannulas were implanted into the right and...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2019.112599

    authors: Salighedar R,Erfanparast A,Tamaddonfard E,Soltanalinejad F

    更新日期:2019-10-01 00:00:00

  • Individual differences in anticipatory activity to food rewards predict cue-induced appetitive 50-kHz calls in rats.

    abstract::Reward-related stimuli come to acquire incentive salience through Pavlovian learning and become capable of controlling reward-oriented behaviors. Here, we examined individual differences in anticipatory activity elicited by reward-related cues as indicative of how animals attribute incentive salience to otherwise neut...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2015.05.012

    authors: Brenes JC,Schwarting RK

    更新日期:2015-10-01 00:00:00

  • Effect of brain lesions on rat shuttle behavior in four different tests.

    abstract::Rats were trained to perform shuttle responses to a buzzer in four different situations: pseudoconditioning or D test (buzzers and footshocks presented at random), classical conditioning or DP test (buzzers and footshocks paired on every trial), avoidance without stimulus pairing or DC test (buzzer-shock intervals var...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(79)90128-8

    authors: Schütz RA,Izquierdo I

    更新日期:1979-07-01 00:00:00

  • Duration of environmental enrichment influences the magnitude and persistence of its behavioral effects on mice.

    abstract::A wide range of data in the literature suggests that environmental enrichment has beneficial effects on various cognitive parameters in rodents. However, the magnitude of these effects and their persistence after the cessation of enrichment vary markedly across studies, with the use of different enrichment protocols p...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2007.09.009

    authors: Amaral OB,Vargas RS,Hansel G,Izquierdo I,Souza DO

    更新日期:2008-01-28 00:00:00

  • Effects of sustained avoidance/escape on demand for food.

    abstract::Rats were concurrently exposed to a sustained avoidance/escape (SAE) procedure and a procedure for assessing demand for food. In the sustained SAE procedure, signalled shock avoidance/escape trials were presented at varying intervals averaging five minutes. The shock could be avoided by pulling on a ceiling chain earl...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(91)90288-y

    authors: Elsmore TF,Kant GJ,Bauman RA

    更新日期:1991-03-01 00:00:00

  • Workshop on taste and smell in the elderly: an overview.

    abstract::The purpose of the workshop entitled Taste and Smell in the Elderly: Behavioral and Nutritional Consequences was 1) to review the current state of knowledge in the area of taste and smell, with emphasis on age-related changes, 2) to identify existing gaps in our knowledge, and 3) to develop future research strategies....

    journal_title:Physiology & behavior

    pub_type:

    doi:10.1016/s0031-9384(98)00261-3

    authors: Finkelstein JA,Schiffman SS

    更新日期:1999-04-01 00:00:00

  • Circadian variations in time perception in rats.

    abstract::The hypothesis that time perception is determined by an internal clock's rate, which is sensitive to physiological circadian changes was examined. This hypothesis suggests that when body temperature and activity increase, clock rate increases causing overestimations of time and a decrease in time interval production. ...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(90)90021-u

    authors: Shurtleff D,Raslear TG,Simmons L

    更新日期:1990-05-01 00:00:00

  • Olfactory bulbectomy disrupts the expression of cocaine-induced conditioned place preference.

    abstract::The role of the olfactory sense in the expression of cocaine-induced conditioned place preference (CPP) was examined in adult male rats (n = 35) of the N/Nih strain. Consistent with the scientific literature, rats were observed to significantly (p < 0.05) increase (double) the seconds spent in their least-preferred ch...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(95)02119-1

    authors: Calcagnetti DJ,Quatrella LA,Schechter MD

    更新日期:1996-04-01 00:00:00