当前位置： SCI文献检索 > PHYSIOLOGY & BEHAVIOR期刊下所有文献 > Repeated gastric distension alters food intake and neuroendocrine profiles in rats.

Repeated gastric distension alters food intake and neuroendocrine profiles in rats.

Abstract：

:The consumption of a large food bolus leads to stomach distension. Gastric distension potently signals the termination of a meal by stimulating gastric mechanoreceptors and activating neuroendocrine circuitry. The ability to terminate a meal is altered in disorders such as bulimia nervosa (BN), binge-eating disorder (BED) and certain subtypes of obesity in which large quantities of food are frequently ingested. When a large meal is consumed, the stomach is rapidly stretched. We modeled this rapid distension of the stomach in order to determine if the neuroendocrine abnormalities present in these disorders, including increased gastric capacit3y, leptin dysregulation, and alterations in neuropeptide Y (NPY), and proopiomelanocortin (POMC) expression, were influenced by the rapid stretch aspect of repeatedly consuming a large meal. To test the effects of repeated gastric distension (RGD) on neuroendocrine factors involved in energy homeostasis, a permanent intra-gastric balloon was implanted in rats, and briefly inflated daily for 4 weeks. Though body weights and daily food intakes remained equivalent in RGD and control rats, a significant delay in the onset of feeding was present during the first and second, but not the third and fourth weeks of inflations. Despite equivalent body weights and daily caloric consumption, RGD animals had significantly decreased leptin levels (p<0.05), and tended to have increased fasting arcuate NPY levels (p=0.08), which were suppressed more than control animals following food intake (control and RGD decreases from baseline were 184.95% and 257.42%, respectively). NPY expression in the nucleus of the solitary tract followed a similar pattern. These data demonstrate that the act of regularly distending the stomach can have effects on the regulation of energy balance that are independent from those related to caloric consumption, and may be related to disorders such as BN, BED, and certain types of obesity in which meal termination is impaired.

journal_name

Physiol Behav

journal_title

Physiology & behavior

authors

Hargrave SL,Kinzig KP

doi

10.1016/j.physbeh.2011.11.006

subject

Has Abstract

pub_date

2012-02-28 00:00:00

pages

975-81

issue

4

eissn

0031-9384

issn

1873-507X

pii

S0031-9384(11)00526-9

journal_volume

105

pub_type

杂志文章

相关文献

PHYSIOLOGY & BEHAVIOR文献大全
  • The role of the midbrain reticular formation in the expression of two opposing nigral denervation syndromes.

    abstract：:The present study investigated the role of the midbrain reticular formation (MRF) in the expression of opposing locomotor asymmetries elicited from the medial and lateral substantia nigra pars compacta (SNC). It was found that unilateral MRF lesions produced ipsiversive circling that was potentiated by amphetamine. La...

    journal_title：Physiology & behavior

    pub_type： 杂志文章

    doi：10.1016/0031-9384(85)90406-8

    authors： Vaccarino FJ,Franklin KB,Prupas D

    更新日期：1985-11-01 00:00:00

  • Baseline transition sleep and associated sleep episodes are related to the learning ability of rats.

    abstract：:The EEGs of 18 adult male Wistar rats were recorded during a baseline session lasting 7 h (day 1). The following day, rats were trained for a 2-way active avoidance task in an automated shuttle-box. A retention test was scheduled on the third day. On the basis of the number of avoidances scored during the training and...

    journal_title：Physiology & behavior

    pub_type： 杂志文章

    doi：10.1016/s0031-9384(96)00302-2

    authors： Vescia S,Mandile P,Montagnese P,Romano F,Cataldo G,Cotugno M,Giuditta A

    更新日期：1996-12-01 00:00:00

  • Amylin decreases meal size in rats.

    abstract：:Adult male rats were intraperitoneally (i.p.) injected with 1.0 microgram/kg amylin at the beginning of the dark phase in 24 h food deprived or undeprived rats, and a computerized system measured feeding behavior. In food deprived rats, amylin reduced the size of the first postdeprivation meal without affecting intram...

    journal_title：Physiology & behavior

    pub_type： 杂志文章

    doi：10.1016/0031-9384(95)02067-5

    authors： Lutz TA,Geary N,Szabady MM,Del Prete E,Scharrer E

    更新日期：1995-12-01 00:00:00

  • Taste aversion in rats induced by forced swimming, voluntary running, forced running, and lithium chloride injection treatments.

    abstract：:The present experiment compared the strengths of taste aversion learning in rats induced by forced swimming in a water pool (5, 15, 30, or 60 min), voluntary running in an activity wheel (15, 30, 60, or 120 min), forced running in a motorized wheel (60 min at the speed of 8 m/min), optional running in the apparatus co...

    journal_title：Physiology & behavior

    pub_type： 杂志文章

    doi：10.1016/j.physbeh.2006.04.013

    authors： Masaki T,Nakajima S

    更新日期：2006-07-30 00:00:00

  • Serotonin involvement in the electroacupuncture- and moxibustion-induced gastric emptying in rats.

    abstract：OBJECTIVE:Electroacupuncture (EA) as well as moxibustion stimulation has been reported to produce an excitatory effect on the gastrointestinal motility of the rat. Serotonergic neurons of the mioenteric and submucous plexus are major participants in the gastrointestinal physiology. Here, we compared the outcomes of the...

    journal_title：Physiology & behavior

    pub_type： 杂志文章

    doi：10.1016/j.physbeh.2004.07.003

    authors： Sugai GC,Freire Ade O,Tabosa A,Yamamura Y,Tufik S,Mello LE

    更新日期：2004-10-15 00:00:00

  • Cold water stress analgesia in rats: differential effects of naltrexone.

    abstract：:Cold water swim (CWS, 2 degrees C, 3.5 min) decreases the responsiveness to nociceptive stimuli in rats. The influence of various parameters of the CWS condition on stress-induced analgesia were evaluated by means of naltrexone effects. Naltrexone dose-dependently (but significantly only at high doses--21 mg/kg) parti...

    journal_title：Physiology & behavior

    pub_type： 杂志文章

    doi：10.1016/0031-9384(84)90308-1

    authors： Girardot MN,Holloway FA

    更新日期：1984-04-01 00:00:00

  • Sexual differentiation of odor and partner preference in the rat.

    abstract：:Previous studies have shown that adult male rats, in which brain estrogen formation was inhibited neonatally by SC administration of the aromatase inhibitor 1,4, 6-androstatriene-3,17-dione (ATD), show an altered sexual partner preference. When tested in a three-compartment box, such gonadally intact ATD males approac...

    journal_title：Physiology & behavior

    pub_type： 杂志文章

    doi：10.1016/s0031-9384(96)80023-0

    authors： Bakker J,Van Ophemert J,Slob AK

    更新日期：1996-08-01 00:00:00

  • Relationships between human thirst, hunger, drinking, and feeding.

    abstract：:There is a widely held view that hunger prompts feeding to ensure energy needs are met, while thirst cues drinking to address hydration requirements. However, recent changes in the nature of the food supply and eating patterns have raised questions about the functionality of these relationships with respect to maintai...

    journal_title：Physiology & behavior

    pub_type： 杂志文章,评审

    doi：10.1016/j.physbeh.2008.04.007

    authors： McKiernan F,Houchins JA,Mattes RD

    更新日期：2008-08-06 00:00:00

  • Mediation of male mouse urine marking and aggression by the vomeronasal organ.

    abstract：:The effects of vomeronasal organ removal (VNX) on male mouse urine marking and aggressive behaviors were investigated. In three different stimulus conditions VNX male marking rates were about half that of sham-operated males. Aggressive behavior was tested by pairing males with male-urine-swabbed castrate males. Only ...

    journal_title：Physiology & behavior

    pub_type： 杂志文章

    doi：10.1016/0031-9384(86)90300-8

    authors： Maruniak JA,Wysocki CJ,Taylor JA

    更新日期：1986-01-01 00:00:00

  • Untangling the effects of hunger, anxiety, and nausea on energy intake during intravenous cholecystokinin octapeptide (CCK-8) infusion.

    abstract：:Infusions of cholecystokinin (CCK) may exert their effects on appetite by inducing feelings of nausea or anxiety. In this double blind, placebo controlled crossover study, the impact of these effects on appetite were examined. Fifteen male subjects received a 20 min i.v. infusion of cholecystokinin octapeptide (CCK-8)...

    journal_title：Physiology & behavior

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：10.1016/s0031-9384(98)00169-3

    authors： Greenough A,Cole G,Lewis J,Lockton A,Blundell J

    更新日期：1998-11-15 00:00:00

  • Circadian rhythms and patterns of running-wheel activity, feeding and drinking behaviors of old male rats.

    abstract：:Running-wheel activity of 7 young adult male rats (3 to 6.5 months of age) and 11 old male rats (22 to 34 months of age), feeding behavior of 10 each of young adult and old male rats and drinking behavior of 6 each of young adult and old male rats were recorded. Circadian rhythms were lost in 2, 6 and 1 old rats respe...

    journal_title：Physiology & behavior

    pub_type： 杂志文章

    doi：10.1016/0031-9384(84)90380-9

    authors： Peng MT,Kang M

    更新日期：1984-10-01 00:00:00

  • Characteristics in aggressive behavior induced by midbrain raphe lesions in rats.

    abstract：:Midbrain raphe lesions induced aggressive behavior which was characterized by defensive aggression rather than offensive aggression in nature. Furthermore, raphe-lesioned rats exhibited muricide. This muricide included not only mouse-killing but also mouse-eating behavior. Both dorsal and medial raphe lesioned (dm-R) ...

    journal_title：Physiology & behavior

    pub_type： 杂志文章

    doi：10.1016/0031-9384(77)90166-4

    authors： Yamamoto T,Ueki S

    更新日期：1977-07-01 00:00:00

  • The circadian rhythm of cortisol in the saliva of young pigs.

    abstract：:Single and population-mean cosinor analyses document a circadian rhythm in salivary cortisol of pigs (p < 0.001). The midline estimated statistic of rhythm, the MESOR (M), is 1.50 +/- 0.07 ng/ml. For the group of 14 pigs studied there was a predictable variation of 64% around this mean in salivary cortisol within a da...

    journal_title：Physiology & behavior

    pub_type： 杂志文章

    doi：10.1016/0031-9384(96)00107-2

    authors： Ekkel ED,Dieleman SJ,Schouten WG,Portela A,Cornélissen G,Tielen MJ,Halberg F

    更新日期：1996-09-01 00:00:00

  • Modeling neural oscillations.

    abstract：:A brief review of oscillatory activity in neurons and networks is given. Conditions required for neural oscillations are provided. Three mathematical methods for studying the coupling between neural oscillators are described: (i) weak coupling, (ii) firing time maps, and (iii) leaky integrate-and-fire methods. Several...

    journal_title：Physiology & behavior

    pub_type： 杂志文章,评审

    doi：10.1016/s0031-9384(02)00898-3

    authors： Ermentrout GB,Chow CC

    更新日期：2002-12-01 00:00:00

  • Testosterone, facial symmetry and cooperation in the prisoners' dilemma.

    abstract：:Recent research has analyzed how individual characteristics, like the exposure to different hormones and symmetry, affect decision-making and strategic behaviour. The present article investigates the effect of symmetry, of exposure to testosterone (T) in utero and during puberty and of current T on cooperation in a Pr...

    journal_title：Physiology & behavior

    pub_type： 杂志文章

    doi：10.1016/j.physbeh.2009.11.013

    authors： Sanchez-Pages S,Turiegano E

    更新日期：2010-03-03 00:00:00

  • Learning from spiny lobsters about chemosensory coding of mixtures.

    abstract：:Studies of the peripheral olfactory system of the Caribbean spiny lobster Panulirus argus and related decapod crustaceans have helped us understand mechanisms of coding of mixtures, some of which are discussed in this review. Although the number of cells in the lobster's olfactory system is much lower than in vertebra...

    journal_title：Physiology & behavior

    pub_type： 杂志文章,评审

    doi：10.1016/s0031-9384(00)00202-x

    authors： Derby CD

    更新日期：2000-04-01 00:00:00

  • Snacking: A cause for concern.

    abstract：:Snacking, like any dietary behavior, can be practiced in a manner that is healthful or not. The case presented in this critical review of the literature is that snacking is problematic, primarily due to its contribution to positive energy balance and promotion of overweight/obesity. There is strong evidence that snack...

    journal_title：Physiology & behavior

    pub_type： 杂志文章,评审

    doi：10.1016/j.physbeh.2018.02.010

    authors： Mattes RD

    更新日期：2018-09-01 00:00:00

  • Behavioral and physiological responses of dairy goats to food thwarting.

    abstract：:Eight Nubian dairy goat does in one experiment, and eight Alpine dairy goat does in a second experiment, were randomly allotted to food-thwarted or fed groups in a crossover experimental design. Food thwarting was hypothesized to produce an emotional state analogous to frustration. After a 1-week training period durin...

    journal_title：Physiology & behavior

    pub_type： 杂志文章

    doi：10.1016/0031-9384(92)90145-r

    authors： Carbonaro DA,Friend TH,Dellmeier GR,Nuti LC

    更新日期：1992-02-01 00:00:00

  • Taste dimensions of monosodium glutamate (MSG) in a food system: role of glutamate in young American subjects.

    abstract：:Freshly cooked chicken broth was prepared with several concentrations (0.06-0.32 M) of added NaCl. In the first study, subjects were presented with pairs of samples, each having the same concentration of NaCl (salt) but one of which contained 0.01 M monosodium glutamate (MSG). The subjects preferred the sample with ad...

    journal_title：Physiology & behavior

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0031-9384(98)00160-7

    authors： Okiyama A,Beauchamp GK

    更新日期：1998-08-01 00:00:00

  • Dual 24-hour feeding response to 2DG in rats: daytime increase and nighttime decrease.

    abstract：:Thirty-six rats were injected IP with 2DG (0, 250, or 500 mg/kg) at 7-day intervals, once at light onset (7 a.m.) and once at dark onset (7 p.m.), and postinjection food intake was monitored for 24 hours. Five hundred mg/kg 2DG caused food intake to rise above control levels during the first 6 hours of daylight, regar...

    journal_title：Physiology & behavior

    pub_type： 杂志文章

    doi：10.1016/0031-9384(89)90179-0

    authors： Thompson CI,Fleming RL,Franken KA,Hornback DA,Boha SP

    更新日期：1989-01-01 00:00:00

  • Heat and social rank impact behavior and physiology of PRRS-virus-infected pigs.

    abstract：:Changes in thermal environment can invoke a stress response in pigs, which in turn can potentially impact their immune system and disease susceptibility. We investigated effects of heat stress and social rank on behavior, immune responsiveness, and performance of pigs challenged with porcine reproductive and respirato...

    journal_title：Physiology & behavior

    pub_type： 杂志文章

    doi：10.1016/j.physbeh.2006.08.029

    authors： Sutherland MA,Niekamp SR,Johnson RW,Van Alstine WG,Salak-Johnson JL

    更新日期：2007-01-30 00:00:00

  • A mouse model of alcoholism.

    abstract：:A model of alcoholism should demonstrate self-administration of alcohol by the animal and a withdrawal syndrome when the animal no longer has access to the drug. A mouse model is described that meets these criteria and enables the induction of "alcoholism" in a large number of animals within a short period of time. Mi...

    journal_title：Physiology & behavior

    pub_type： 杂志文章

    doi：10.1016/0031-9384(82)90333-x

    authors： Rijk H,Crabbe JC,Rigter H

    更新日期：1982-11-01 00:00:00

  • Effects of light intensity on passive avoidance behavior of male and female Wistar rats.

    abstract：:Groups of intact male and female Wistar rats were exposed to a standard passive avoidance procedure. The intensity of the light bulb illuminating the platform during adaptation, pre- and post-shock trials was manipulated (5, 25 or 75 W). Entrance latencies during pre-shock trials were longer for males than for females...

    journal_title：Physiology & behavior

    pub_type： 杂志文章

    doi：10.1016/0031-9384(86)90084-3

    authors： van Haaren F,van de Poll NE

    更新日期：1986-01-01 00:00:00

  • Gonadal ERα/β, AR and TRPV1 gene expression: modulation by pain and morphine treatment in male and female rats.

    abstract：:The results of several studies strongly indicate a bidirectional relationship among gonadal hormones and pain. While gonadal hormones play a key role in pain modulation, they have been found to be affected by pain therapies in different experimental and clinical conditions. However, the effects of pain and pain therap...

    journal_title：Physiology & behavior

    pub_type： 杂志文章

    doi：10.1016/j.physbeh.2012.12.014

    authors： Vodo S,Arcelli D,Fiorenzani P,Meriggiola MC,Butkevich I,Di Canio C,Mikhailenko V,Aloisi AM

    更新日期：2013-02-17 00:00:00

  • The effect of feeding on defecation behaviour in pigs.

    abstract：:The effect of eating on defecation behaviour was investigated in four 20-30 kg pigs. Rectal distention stimulation was performed pre- and postprandially at 10 cm from the anus with a 5 cm latex balloon. Volume was increased in steps of 10 ml up to 200 ml of air or until balloon defecation. Dependent measures were volu...

    journal_title：Physiology & behavior

    pub_type： 杂志文章

    doi：10.1016/0031-9384(92)90190-d

    authors： Musial F,Crowell MD,French AW

    更新日期：1992-03-01 00:00:00

  • Influence of aerobic fitness, activity level, and smoking history on the acute thermic effect of nicotine.

    abstract：:Individual variability in sensitivity to the acute thermic effects of nicotine has been difficult to study because of methodological limitations in the use of smoking to manipulate nicotine dose. This study examined the influence of smoking history, body composition, and, in a subset of subjects, aerobic fitness and p...

    journal_title：Physiology & behavior

    pub_type： 临床试验,杂志文章

    doi：10.1016/0031-9384(94)00381-e

    authors： Perkins KA,Sexton JE

    更新日期：1995-06-01 00:00:00

  • Protective effect of n-butanol extract from Alpinia oxyphylla on learning and memory impairments.

    abstract：:Alzheimer's disease (AD) is one of the major neurological diseases of the elderly. How to safely and effectively remove the toxic Aβ42 peptide through blood-brain barrier (BBB) is considered to be an effective method for the prevention and treatment of AD. The compounds whose molecule weight is less than 400 Da and th...

    journal_title：Physiology & behavior

    pub_type： 杂志文章

    doi：10.1016/j.physbeh.2014.11.016

    authors： Shi SH,Zhao X,Liu AJ,Liu B,Li H,Wu B,Bi KS,Jia Y

    更新日期：2015-02-01 00:00:00

  • Efficacy of fasting calorie restriction on quality of life among aging men.

    abstract：:Calorie restriction (CR) has been promoted to increase longevity. Previous studies have indicated that CR can negatively affect mood and therefore the effect of CR on mood and quality of life (QOL) becomes crucial when considering the feasibility of CR in humans. We conducted a three month clinical trial on CR (reduct...

    journal_title：Physiology & behavior

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.physbeh.2011.07.007

    authors： Teng NI,Shahar S,Manaf ZA,Das SK,Taha CS,Ngah WZ

    更新日期：2011-10-24 00:00:00

  • Long-term changes in open field behaviour following a single social defeat in rats can be reversed by sleep deprivation.

    abstract：:The long-term consequences of a single social defeat on open field behaviour in rats were studied, with special emphasis on the time course of stress-induced changes. Animals were subjected to social defeat by placing them into the territory of an aggressive male conspecific for 1 h. After the defeat session experimen...

    journal_title：Physiology & behavior

    pub_type： 杂志文章

    doi：10.1016/0031-9384(95)02271-6

    authors： Meerlo P,Overkamp GJ,Benning MA,Koolhaas JM,Van den Hoofdakker RH

    更新日期：1996-07-01 00:00:00

  • Prolonged ethanol consumption influences shuttle box and passive avoidance performance in rats.

    abstract：:Rats were chronically maintained on an ethanol liquid diet for 16 days. Three weeks after cessation of ethanol intake, animals were tested for the acquisition of shuttle box avoidance and the retention of passive avoidance behaviour. Alcohol consuming rats showed a significant impairment of acquisition in the shuttle ...

    journal_title：Physiology & behavior

    pub_type： 杂志文章

    doi：10.1016/0031-9384(85)90099-x

    authors： Guaza C,Borrell J

    更新日期：1985-02-01 00:00:00