Influence of aerobic fitness, activity level, and smoking history on the acute thermic effect of nicotine.


:Individual variability in sensitivity to the acute thermic effects of nicotine has been difficult to study because of methodological limitations in the use of smoking to manipulate nicotine dose. This study examined the influence of smoking history, body composition, and, in a subset of subjects, aerobic fitness and physical activity on the thermic effect of nicotine using a measured-dose nasal spray procedure. Following overnight fasting and smoking abstinence, 38 healthy male smokers were intermittently administered a nicotine dose corrected for body weight (15 micrograms/kg, approx. 1.1 mg for average subject) or placebo on separate occasions in a within-subjects study. Indirect calorimetry was used to assess resting energy expenditure (REE) before and after dosing. Acute thermic response to nicotine ranged from -4.3 to +10.8 kcal/h (-5.4% to +12.6% of REE). Thermic response to nicotine was correlated significantly with aerobic fitness (r = 0.58, p < 0.005), physical activity (r = 0.44, p < 0.05), and number of pack-years of smoking (r = 0.43, p < 0.01). Thermic response was marginally correlated with percent body fat (r = -0.23, p < 0.10), but not with body weight (r = 0.04), percent of ideal weight for height (r = -0.10), or lean body mass (r = 0.05). These results indicate that male smokers higher in fitness and activity and with greater smoking exposure histories may experience greater increases in energy expenditure as a result of nicotine intake via smoking. Consequently, variability in these characteristics could help account for some of the variability in weight gain after stopping smoking.


Physiol Behav


Physiology & behavior


Perkins KA,Sexton JE




Has Abstract


1995-06-01 00:00:00














  • Gender differences in smiling: An evolutionary neuroandrogenic theory.

    abstract::Studies have found that, under a wide variety of social circumstances, females are more likely than males to smile. The present article offers a theoretical explanation for this difference based on the premise that testosterone (along with other sex hormones) has evolved the tendency to alter brain functioning in ways...

    journal_title:Physiology & behavior

    pub_type: 杂志文章,评审


    authors: Ellis L

    更新日期:2006-07-30 00:00:00

  • Regulation of milk ingestion in the infant rat.

    abstract::The aim of this study was to differentiate between maternal and offspring factors involved in the control of milk ingestion. Specifically, we investigated: (1) the temporal pattern of milk ingestion in fasted and non-fasted sucklings; (2) the amount of milk released as compared to that of milk available; and (3) the r...

    journal_title:Physiology & behavior

    pub_type: 杂志文章


    authors: Lau C,Henning SJ

    更新日期:1984-11-01 00:00:00

  • The effects of subdiaphragmatic vagotomy on circadian corticosterone rhythmicity in rats with continuous or restricted food access.

    abstract::Plasma corticosteroid circadian periodicity was determined in three groups of individual adult male rats. Categories were: post-subdiaphragmatic vagotomy, sham-operated, and controls. Blood was sampled every 4 hours over a 48-hour period with ad lib feeding and after a 13-day period on daytime (0930--1330) restriction...

    journal_title:Physiology & behavior

    pub_type: 杂志文章


    authors: Moreira AC,Krieger DT

    更新日期:1982-05-01 00:00:00

  • Distinct substrates influence the acquisition of self-stimulation of the hippocampus and the prefrontal cortex.

    abstract::Self-stimulation (SS) of both the medial prefrontal cortex (MPFC) and the dorsolateral hippocampus (HPC) is known to develop slowly, over a period of days. In both cases, the acquisition of bar-pressing can be markedly hastened by delivery of noncontingent electrical stimulation for several days prior to SS training. ...

    journal_title:Physiology & behavior

    pub_type: 杂志文章


    authors: Robertson A,Laferrière A,Milner PM

    更新日期:1986-01-01 00:00:00

  • Short-term effects of a novel fat emulsion on appetite and food intake.

    abstract::The objective of the study was to confirm the satiety/energy intake effect of a novel fat emulsion (Olibra) versus placebo in the short term. A randomized, double-blind, placebo-controlled, crossover design was used. 41 subjects participated in the study (n=21: junior-normal weight: age 23.7+/-2.8 years; BMI: 22.0+/-1...

    journal_title:Physiology & behavior

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Diepvens K,Steijns J,Zuurendonk P,Westerterp-Plantenga MS

    更新日期:2008-09-03 00:00:00

  • Testosterone, facial symmetry and cooperation in the prisoners' dilemma.

    abstract::Recent research has analyzed how individual characteristics, like the exposure to different hormones and symmetry, affect decision-making and strategic behaviour. The present article investigates the effect of symmetry, of exposure to testosterone (T) in utero and during puberty and of current T on cooperation in a Pr...

    journal_title:Physiology & behavior

    pub_type: 杂志文章


    authors: Sanchez-Pages S,Turiegano E

    更新日期:2010-03-03 00:00:00

  • Changes of brain serotonin and muricide behavior following chronic administration of theophylline in rats.

    abstract::Temporal modification of amygdaloid serotonin (5HT) content and the resultant muricide behavior, compared to isolated and olfactory bulbectomized rats, were studied after chronic theophylline administration. Theophylline raised amygdaloid 5HT after Day 28 and amygdaloid 5-hydroxyindoleacetic acid (5HIAA), its deaminat...

    journal_title:Physiology & behavior

    pub_type: 杂志文章


    authors: Sakata T,Fuchimoto H,Kodama J,Fukushima M

    更新日期:1975-10-01 00:00:00

  • Protective effect of n-butanol extract from Alpinia oxyphylla on learning and memory impairments.

    abstract::Alzheimer's disease (AD) is one of the major neurological diseases of the elderly. How to safely and effectively remove the toxic Aβ42 peptide through blood-brain barrier (BBB) is considered to be an effective method for the prevention and treatment of AD. The compounds whose molecule weight is less than 400 Da and th...

    journal_title:Physiology & behavior

    pub_type: 杂志文章


    authors: Shi SH,Zhao X,Liu AJ,Liu B,Li H,Wu B,Bi KS,Jia Y

    更新日期:2015-02-01 00:00:00

  • Simultaneous measurement of endogenous steroid hormones and their metabolites with LC-MS/MS in faeces of a New World primate species, Cebus capucinus.

    abstract::We developed and validated a method to measure steroid hormones with liquid chromatography-tandem mass spectrometry (LC-MS/MS) in faecal samples of white-faced capuchins. The method includes the measurement of adrenal and gonadal hormones such as cortisol, testosterone, estrone, progesterone and a number of their faec...

    journal_title:Physiology & behavior

    pub_type: 杂志文章


    authors: Weltring A,Schaebs FS,Perry SE,Deschner T

    更新日期:2012-01-18 00:00:00

  • Acoustic startle and open-field behavior in mice bred for magnitude of swim analgesia.

    abstract::Acoustic startle response (ASR) and open-field activity was examined in the 46th generation of mice that have been selectively bred for high analgesia (HA) and for low analgesia (LA) induced by 3-min swimming in 20 degrees C water. These lines were earlier found to differ in brain opioid receptor density and in the ex...

    journal_title:Physiology & behavior

    pub_type: 杂志文章


    authors: Błaszczyk JW,Tajchert K,Lapo I,Sadowski B

    更新日期:2000-09-15 00:00:00

  • Changes in the sexual behavior and testosterone levels of male rats in response to daily interactions with estrus females.

    abstract::Male rat sexual behavior has been intensively studied over the past 100 years, but few studies have examined how sexual behavior changes over the course of several days of interactions. In this experiment, adult male rats in the experimental group (n=12) were given daily access to estrus females for 30 min per day for...

    journal_title:Physiology & behavior

    pub_type: 杂志文章


    authors: Shulman LM,Spritzer MD

    更新日期:2014-06-22 00:00:00

  • Comparison of two isometric handgrip protocols on sympathetic arousal in women.

    abstract::Isometric handgrip is commonly used in stress research because the task reliably increases sympathetic arousal. Various handgrip protocols have been used; they vary in handgrip strength, duration of grip, and the number of cycles of handgrip and rest. However, most protocols require the calibration of a maximum volunt...

    journal_title:Physiology & behavior

    pub_type: 杂志文章


    authors: Nielsen SE,Mather M

    更新日期:2015-04-01 00:00:00

  • Exogenous oxytocin attenuates suckling-induced prolactin release but not maternal or infant behavior in lactating rats.

    abstract::The influence of exogenous oxytocin (OT) on maternal and infant behavior over 60 min of suckling, which followed 6 h of isolation, was investigated on Day 12 of lactation in rats. Mothers administered 1 IU of OT or saline through an indwelling atrial catheter and their litters indicated a similar nursing and suckling ...

    journal_title:Physiology & behavior

    pub_type: 杂志文章


    authors: Yamamuro Y,Sensui N

    更新日期:1998-03-01 00:00:00

  • Yolk testosterone levels and offspring phenotype correlate with parental age in a precocial bird.

    abstract::Parents, and particularly mothers, can influence their offspring's development in non-genetic ways. Maternal effects can occur during the mothering phase as well as during the embryonic phase. Prenatal maternal effects in birds can be mediated by yolk steroid hormones that influence subsequent offspring development. S...

    journal_title:Physiology & behavior

    pub_type: 杂志文章


    authors: Guibert F,Richard-Yris MA,Lumineau S,Kotrschal K,Möstl E,Houdelier C

    更新日期:2012-01-18 00:00:00

  • Altered T-lymphocyte response following aggressive encounters in mice.

    abstract::Intermale aggression is a natural form of psychosocial stress that can alter a variety of physiological functions, including immune function. In Experiment 1, daily fighting between pairs of previously isolated male mice differentially altered immunological measures of T-cell responsiveness in dominant and submissive ...

    journal_title:Physiology & behavior

    pub_type: 杂志文章


    authors: Hardy CA,Quay J,Livnat S,Ader R

    更新日期:1990-06-01 00:00:00

  • Central amylin acts as an adiposity signal to control body weight and energy expenditure.

    abstract::The pancreatic B-cell hormone amylin has been proposed to be both a satiation signal and an adiposity signal. The effects of peripheral amylin on energy balance are well investigated, but the effects of central amylin are less clear. We determined the effects of low doses of amylin administered into the 3rd cerebral v...

    journal_title:Physiology & behavior

    pub_type: 杂志文章


    authors: Wielinga PY,Löwenstein C,Muff S,Munz M,Woods SC,Lutz TA

    更新日期:2010-08-04 00:00:00

  • Alarm pheromone enhances stress-induced hyperthermia in rats.

    abstract::Behavioral and physiological effects of alarm pheromones emanating from stressed conspecific animals were investigated. Experimentally naive male Wistar rats were exposed to the test chambers containing alarm pheromones, which had been released by other rats receiving foot shocks in the same chamber beforehand. Along ...

    journal_title:Physiology & behavior

    pub_type: 杂志文章


    authors: Kikusui T,Takigami S,Takeuchi Y,Mori Y

    更新日期:2001-01-01 00:00:00

  • Circulating levels of endocannabinoids respond acutely to voluntary exercise, are altered in mice selectively bred for high voluntary wheel running, and differ between the sexes.

    abstract::The endocannabinoid system serves many physiological roles, including in the regulation of energy balance, food reward, and voluntary locomotion. Signaling at the cannabinoid type 1 receptor has been specifically implicated in motivation for rodent voluntary exercise on wheels. We studied four replicate lines of high ...

    journal_title:Physiology & behavior

    pub_type: 杂志文章


    authors: Thompson Z,Argueta D,Garland T Jr,DiPatrizio N

    更新日期:2017-03-01 00:00:00

  • Water intake of Djungarian and Syrian hamsters treated with various dipsogenic stimuli.

    abstract::Djungarian and Syrian hamsters were found to exhibit robust water intake following water deprivation, and in response to hyperosmotic and hypovolumetric challenges to body fluids following injections of hypertonic NaCl and polyethylene glycol, respectively. Water intake was not stimulated following peripheral injectio...

    journal_title:Physiology & behavior

    pub_type: 杂志文章


    authors: Rowland NE

    更新日期:1988-01-01 00:00:00

  • Heat and social rank impact behavior and physiology of PRRS-virus-infected pigs.

    abstract::Changes in thermal environment can invoke a stress response in pigs, which in turn can potentially impact their immune system and disease susceptibility. We investigated effects of heat stress and social rank on behavior, immune responsiveness, and performance of pigs challenged with porcine reproductive and respirato...

    journal_title:Physiology & behavior

    pub_type: 杂志文章


    authors: Sutherland MA,Niekamp SR,Johnson RW,Van Alstine WG,Salak-Johnson JL

    更新日期:2007-01-30 00:00:00

  • Relationships between human thirst, hunger, drinking, and feeding.

    abstract::There is a widely held view that hunger prompts feeding to ensure energy needs are met, while thirst cues drinking to address hydration requirements. However, recent changes in the nature of the food supply and eating patterns have raised questions about the functionality of these relationships with respect to maintai...

    journal_title:Physiology & behavior

    pub_type: 杂志文章,评审


    authors: McKiernan F,Houchins JA,Mattes RD

    更新日期:2008-08-06 00:00:00

  • Learned suppression of intake based on anticipated calories: cross-nutrient comparisons.

    abstract::Following training with distinctively flavored solutions which differ in calories and thus in their postingestive effects, rats demonstrate flavor-postingestive consequence learning by preferentially consuming one of the flavors in two-bottle tests (both flavors presented in nutrient-identical solutions). The directio...

    journal_title:Physiology & behavior

    pub_type: 杂志文章


    authors: Warwick ZS,Bowen KJ,Synowski SJ

    更新日期:1997-12-01 00:00:00

  • Accumulating evidence supports a taste component for free fatty acids in humans.

    abstract::The requisite criteria for what constitutes a taste primary have not been established. Recent advances in understanding of the mechanisms and functions of taste have prompted suggestions for an expanded list of unique taste sensations, including fat, or more specifically, free fatty acids (FFA). A set of criteria are ...

    journal_title:Physiology & behavior

    pub_type: 杂志文章,评审


    authors: Mattes RD

    更新日期:2011-09-26 00:00:00

  • Modulation of plasma glucose by the medial preoptic area in freely moving rats.

    abstract::The effect of norepinephrine (NE) injection into the medial preoptic area (MPOA) on plasma glucose was studied in freely moving male rats. The rats were implanted with chronic jugular catheters for blood sampling and with unilateral intracerebral cannulas placed just above the MPOA. Blood samples were taken immediatel...

    journal_title:Physiology & behavior

    pub_type: 杂志文章


    authors: De Castro MG,Foscolo RB,Reis AM,Coimbra CC

    更新日期:1997-02-01 00:00:00

  • Snacking: A cause for concern.

    abstract::Snacking, like any dietary behavior, can be practiced in a manner that is healthful or not. The case presented in this critical review of the literature is that snacking is problematic, primarily due to its contribution to positive energy balance and promotion of overweight/obesity. There is strong evidence that snack...

    journal_title:Physiology & behavior

    pub_type: 杂志文章,评审


    authors: Mattes RD

    更新日期:2018-09-01 00:00:00

  • Physiological responses to central and peripheral injections of compound 48/80 and histamine in chicks.

    abstract::Mast cells are a type of immune cell widely distributed in the body of vertebrates. Mast cells have many granules that contain several bioactive molecules such as histamine, and these molecules are released through degranulation when the mast cell receives certain stimuli. Because the number of mast cells increases du...

    journal_title:Physiology & behavior

    pub_type: 杂志文章


    authors: Tachibana T,Hirai M,Tomita A,Ishimaru Y,Khan MSI,Makino R,Cline MA

    更新日期:2019-11-01 00:00:00

  • A selective serotonin reuptake inhibitor reduces REM sleep in the homing pigeon.

    abstract::Avian and mammalian 'rapid eye movement' sleep (REM sleep) resemble each other in several aspects. However, the question of whether REM sleep has a shared evolutionary ancestry in birds and mammals has yet to be thoroughly explored. The brain regions and neurotransmitter systems involved in the generation of mammalian...

    journal_title:Physiology & behavior

    pub_type: 杂志文章


    authors: Fuchs T,Siegel JJ,Burgdorf J,Bingman VP

    更新日期:2006-03-30 00:00:00

  • The effects of early dietary experience on subsequent protein selection in the rat.

    abstract::Two series of experiments were designed to investigate the effects of protein composition of the first solid food consumed by young rat pups on their subsequent protein intake after weaning. In the first series of experiments, pups were allowed access to the maternal diet between 17 and 21 days of age, then weaned to ...

    journal_title:Physiology & behavior

    pub_type: 杂志文章


    authors: Morris P,Anderson GH

    更新日期:1986-01-01 00:00:00

  • Effect of low frequency electrical stimulation on seizure-induced short- and long-term impairments in learning and memory in rats.

    abstract::Kindled seizures can impair learning and memory. In the present study the effect of low-frequency electrical stimulation (LFS) on kindled seizure-induced impairment in spatial learning and memory was investigated and followed up to one month. Animals were kindled by electrical stimulation of hippocampal CA1 area in a ...

    journal_title:Physiology & behavior

    pub_type: 杂志文章


    authors: Esmaeilpour K,Sheibani V,Shabani M,Mirnajafi-Zadeh J

    更新日期:2017-01-01 00:00:00

  • Antipsychotic drug and body weight set-point.

    abstract:OBJECTIVE:Antipsychotic (AP) drugs frequently induce weight gain. The present study aimed at exploring a potential association between antipsychotic-induced weight gain and delayed negative alliesthesia for sweet stimuli. RESEARCH METHODS AND PROCEDURES:The study aimed at recruiting patients undergoing AP treatment, h...

    journal_title:Physiology & behavior

    pub_type: 临床试验,杂志文章


    authors: Khazaal Y,Chatton A,Claeys F,Ribordy F,Zullino D,Cabanac M

    更新日期:2008-09-03 00:00:00