Abstract：
:Neurogenic orthostatic hypotension (NOH) is characterized by a drop in systolic blood pressure (SBP) ≥20 mmHg or diastolic blood pressure (DBP) ≥10 mmHg within three minutes of upright posture. NOH is common in the elderly population. This group of individuals is at an increased risk for deficits in multiple cognitive domains such as information processing speed (IPS) and attention. The objective of the current study was to investigate the change in IPS and attention during head-up tilt (HUT) in patients with NOH compared to controls. Cognitive function was assessed in the supine and HUT positions using the symbol digit modalities test (SDMT) which assesses IPS and the Stroop Test which measures attention. 40 participants completed the study, 20 controls (age 64.50 ± 9.25) and 20 NOH patients (age 69.55 ± 7.43) with associated conditions of Parkinson's disease (n = 11), multiple systems atrophy (n = 3), early Lewy body dementia (n = 1) and idiopathic NOH (n = 5). NOH patients had no difference in IPS between supine (43.20 ± 15.26) and HUT (42.90 ± 14.33; p = .77). Controls had significantly faster IPS in the HUT position (69.90 ± 12.02) compared to supine (63.55 ± 9.96; p < .001). NOH patients had significantly slower IPS in both the supine and HUT position compared to controls (p < .001). Attention in the HUT position was significantly worse in NOH patients (-14.86 ± 8.96) compared to controls (-8.68 ± 7.13; p = .029). During HUT, NOH patients experienced a significant decrease in mean SBP by -64.11 ± 18.96 from baseline, whereas controls only had a mean decrease of -5.69 ± 7.65. It is evident that NOH patients have impaired IPS and attention compared to controls and likely plays an important role in the morbidity of these individuals.
journal_name
Physiol Behavjournal_title
Physiology & behaviorauthors
Robinson L,Kimpinski Kdoi
10.1016/j.physbeh.2019.112682subject
Has Abstractpub_date
2019-11-01 00:00:00pages
112682eissn
0031-9384issn
1873-507Xpii
S0031-9384(19)30209-4journal_volume
211pub_type
杂志文章abstract：:Testosterone (T) is critical for maintaining male sexual behavior (MSB) in rodents, in part by altering protein synthesis in a well-defined neural circuit. The specific timing of protein synthesis essential for expression of MSB has never been investigated. We administered the protein synthesis inhibitor anisomycin (A...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2011.08.025
更新日期：2012-01-18 00:00:00
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journal_title：Physiology & behavior
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更新日期：1990-06-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2014.03.008
更新日期：2014-05-10 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2020.113140
更新日期：2020-12-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
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更新日期：1986-01-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2013.06.005
更新日期：2013-07-02 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(82)90161-5
更新日期：1982-06-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
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更新日期：2015-12-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(91)90334-k
更新日期：1991-06-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
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更新日期：2016-02-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.physbeh.2012.08.004
更新日期：2012-10-10 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/s0031-9384(02)00875-2
更新日期：2002-11-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/s0031-9384(01)00674-6
更新日期：2002-03-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 更正并重新发布的文章,杂志文章
doi：10.1016/s0031-9384(99)00061-x
更新日期：1999-03-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2015.02.019
更新日期：2015-04-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章,评审
doi：10.1016/j.physbeh.2006.03.034
更新日期：2006-07-30 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2006.04.013
更新日期：2006-07-30 00:00:00
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更新日期：1985-03-01 00:00:00
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更新日期：2016-10-15 00:00:00
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更新日期：1985-02-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章,评审
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更新日期：2020-12-01 00:00:00
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journal_title：Physiology & behavior
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更新日期：1994-10-01 00:00:00
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journal_title：Physiology & behavior
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更新日期：2006-02-28 00:00:00
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journal_title：Physiology & behavior
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更新日期：2010-08-04 00:00:00
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journal_title：Physiology & behavior
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更新日期：1992-09-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章,评审
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更新日期：2002-12-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2006.04.003
更新日期：2006-07-30 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
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更新日期：1988-01-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
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更新日期：1998-11-15 00:00:00
