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Sexual experience blocks the ability of clitoral stimulation to induce a conditioned place preference in the rat.

Abstract：

:We have previously established the rewarding value of clitoral stimulation (CLS) through the demonstration that manual, distributed, CLS induces a significant conditioned place preference (CPP) and conditioned partner preference in naïve, hormonally primed and non-hormonally primed rats. The present experiment asks whether previous sexual experience might inhibit the ability of clitoral stimulation to induce a conditioned place preference. Female Long-Evans rats were ovariectomized and treated with 10 μg of estradiol benzoate (EB) 48 h and 500 μg of progesterone (P) 4h prior to receiving either 0, 1, or 5 consecutive copulatory sessions with a sexually vigorous male. Each copulatory session ended when females received at least 1 ejaculation. Females then experienced 10 alternating trials of distributed CLS or no CLS paired with one side of a non-biased CPP box under the same hormone-priming regimen. Females that experienced 5 consecutive copulatory sessions did not develop a significant place preference indicated by both a preference score (the proportion of time spent in the reinforced chamber) and a difference score (time in the non-reinforced chamber minus the time in the reinforced chamber) compared prior to and following the 10 conditioning trials. This suggests that repeated copulatory experience might induce a desensitization of the genitosensory circuit since copulation includes both clitoral, and vaginocervical stimulation from mounts plus intromissions. Alternatively, repeated sexual experience prior to conditioning may generate a UCS pre-exposure effect that cannot be altered when manual clitoral stimulation is paired with a new environment.

journal_name

Physiol Behav

journal_title

Physiology & behavior

authors

Parada M,Jafari N,Pfaus JG

doi

10.1016/j.physbeh.2013.06.005

subject

Has Abstract

pub_date

2013-07-02 00:00:00

pages

97-102

eissn

0031-9384

issn

1873-507X

pii

S0031-9384(13)00191-1

journal_volume

119

pub_type

杂志文章

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