Abstract:
:Nicotine exposure during development can alter behavior in adulthood in mice. One route of nicotine administration that can mimic some of the dynamics of human smoking is administration of the drug to pregnant and nursing mice through the drinking water. It is critical to determine if nicotine administration has an impact on maternal behavior as such changes could lead to persistent behavioral alterations in the offspring, independent of the neuropharmacological effects of the drug. While a number of studies have detected nicotine exposure-induced changes, the effects of nicotine administration through the drinking water on maternal behavior in mice have not been examined comprehensively. In the current study we have compared maternal behaviors of C57BL/6J mice exposed to nicotine in the drinking water to behaviors of animals exposed to saccharin (vehicle) in the drinking water for the first 7days after birth of their litters and find no significant between-group differences in any behaviors measured except passive nursing. We have also assessed the effects of nicotine administration through the drinking water on postnatal weight gain of the pups and find no significant differences between groups. Open-field locomotor activity differences between exposed and unexposed offspring in adolescence were also assessed, with transient hyperactivity detected in nicotine-exposed mice. These data suggest that behavioral differences identified between animals exposed to nicotine through maternal drinking water administration are primarily due to the neuropharmacological effects of the drug and not due to effects of exposure on maternal behavior.
journal_name
Physiol Behavjournal_title
Physiology & behaviorauthors
Heath CJ,Horst NK,Picciotto MRdoi
10.1016/j.physbeh.2010.08.021subject
Has Abstractpub_date
2010-12-02 00:00:00pages
764-9issue
5eissn
0031-9384issn
1873-507Xpii
S0031-9384(10)00316-1journal_volume
101pub_type
杂志文章abstract::The electromotor behavior evoked by novel sensory stimuli in the electrogenic teleost fish Gnathonemus petersii was examined. Novelty responses (NRs) consisted of a transient accelerations of the rate of electric organ discharges following a change in sensory input. NRs were basically similar in nontreated and in immo...
journal_title:Physiology & behavior
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更新日期:1999-12-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2018-07-01 00:00:00
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journal_title:Physiology & behavior
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doi:10.1016/0031-9384(88)90209-0
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abstract::Evaluation of the participation of different substantia nigra sites in the sensitization of resistant (R) animals to audiogenic seizures (AS), was performed after series of small (5 mC; n = 28), medium (10 mC; n = 57) and large (15 mC; 3 points of 5 mC each, n = 19) unilateral electrolytic lesions of the substantia ni...
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journal_title:Physiology & behavior
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更新日期:1990-10-01 00:00:00
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journal_title:Physiology & behavior
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更新日期:1995-05-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.physbeh.2011.09.025
更新日期:2012-02-01 00:00:00
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journal_title:Physiology & behavior
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1985-10-01 00:00:00
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更新日期:1992-09-01 00:00:00
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journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(87)90383-0
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pub_type: 杂志文章
doi:10.1016/s0031-9384(96)00247-8
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pub_type: 杂志文章
doi:10.1016/s0031-9384(01)00566-2
更新日期:2001-10-01 00:00:00
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journal_title:Physiology & behavior
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1999-08-01 00:00:00
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journal_title:Physiology & behavior
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journal_title:Physiology & behavior
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journal_title:Physiology & behavior
pub_type: 杂志文章
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更新日期:1983-09-01 00:00:00
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journal_title:Physiology & behavior
pub_type: 杂志文章
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journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(84)90171-9
更新日期:1984-09-01 00:00:00
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pub_type: 杂志文章
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journal_title:Physiology & behavior
pub_type: 杂志文章
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更新日期:1988-01-01 00:00:00
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journal_title:Physiology & behavior
pub_type: 杂志文章
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更新日期:1992-06-01 00:00:00
abstract::In Experiment 1, an SC injection of 14 micrograms CRH greatly suppressed the vocalizing of isolated guinea pig pups 1 h later and produced highly elevated plasma cortisol levels. In Experiment 2, SC injection of 18 international units of ACTH produced similar cortisol elevations, but had a negligible effect on vocaliz...
journal_title:Physiology & behavior
pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:1986-01-01 00:00:00