Abstract：
:Appetite and eating are not only controlled by energy needs, but also by extrinsic factors that are not directly related to energy balance. Environmental signals that acquire motivational properties through associative learning-learned cues-can override homeostatic signals and stimulate eating in sated states, or inhibit eating in states of hunger. Such influences are important, as environmental factors are believed to contribute to the increased susceptibility to overeating and the rise in obesity in the developed world. Similarly, environmental and social factors contribute to the onset and maintenance of anorexia nervosa and other eating disorders through interactions with the individual genetic background. Nevertheless, how learning enables environmental signals to control feeding, and the underlying brain mechanisms are poorly understood. We developed two rodent models to study how learned cues are integrated with homeostatic signals within functional forebrain networks, and how these networks are modulated by experience. In one model, a cue previously paired with food when an animal was hungry induces eating in sated rats. In the other model, food-deprived rats inhibit feeding when presented with a cue that signals danger, a tone previously paired with footshocks. Here evidence will be reviewed that the forebrain network formed by the amygdala, lateral hypothalamus and medial prefrontal cortex mediates cue-driven feeding, while a parallel amygdalar circuitry mediates suppression of eating by the fear cue. Findings from the animal models may be relevant for understanding aspects of human appetite and eating, and maladaptive mechanisms that could lead to overeating and anorexia.
journal_name
Physiol Behavjournal_title
Physiology & behaviorauthors
Petrovich GDdoi
10.1016/j.physbeh.2011.04.059subject
Has Abstractpub_date
2011-09-26 00:00:00pages
582-9issue
4eissn
0031-9384issn
1873-507Xpii
S0031-9384(11)00218-6journal_volume
104pub_type
杂志文章,评审abstract：OBJECTIVE:Larger food portions lead to increased intake but the mechanism behind this effect is unclear. We investigated the effect of portion size on bite size, eating rate, deceleration rate, and meal duration. DESIGN AND METHODS:Thirty-seven overweight women attended 5 visits after a 3 h fast and consumed a 229, 30...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2014.11.041
更新日期：2015-02-01 00:00:00
abstract：:Sleep, waking, and EEG power spectra were investigated in rats with spinal 5,6-dihydroxytryptamine (5,6-DHT) lesions, following 20 mg/kg zimeldine or vehicle IP injections. 5,6-DHT selectively lesioned the descending serotonergic pathways. Lesion alone did not change sleep and waking stages compared to baseline, excep...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(94)00370-k
更新日期：1995-05-01 00:00:00
abstract：:Environmental enrichment is intended to improve the welfare of laboratory animals. However, regarding male mice, numerous studies indicate an increase in aggressive behavior due to cage structuring. On the one hand, this might be a problem concerning animal welfare. On the other hand, enrichment is though to hamper en...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2004.05.009
更新日期：2004-10-15 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章,评审
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更新日期：2002-07-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2004.01.003
更新日期：2004-03-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章,评审
doi：10.1016/s0031-9384(01)00496-6
更新日期：2001-06-01 00:00:00
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pub_type： 杂志文章
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更新日期：1983-06-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2012.06.017
更新日期：2012-09-10 00:00:00
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pub_type： 杂志文章
doi：10.1016/s0031-9384(01)00638-2
更新日期：2002-02-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/s0031-9384(98)00243-1
更新日期：1999-01-01 00:00:00
abstract：:The effects of self and cross-adaptation of acetic acid and HCl solutions on the perception of sourness, were investigated using a filter paper method. In contrast to acetic acid and to pH-buffered acetic acid solutions, self-adaptation could not be obtained with HCl. In fact the sourness of the HCl test-stimulus afte...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(87)90111-9
更新日期：1987-01-01 00:00:00
abstract：:The effects of vomeronasal organ removal (VNX) on male mouse urine marking and aggressive behaviors were investigated. In three different stimulus conditions VNX male marking rates were about half that of sham-operated males. Aggressive behavior was tested by pairing males with male-urine-swabbed castrate males. Only ...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(86)90300-8
更新日期：1986-01-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 临床试验,杂志文章
doi：10.1016/s0031-9384(98)00046-8
更新日期：1998-05-01 00:00:00
abstract：:We examined the physiological and psychological status of men and women who spent the summer (n=100) and/or winter (n=85) seasons in Antarctica at McMurdo (latitude 78.48 S, elevation 12 m) and South Pole (latitude 90 S, elevation 3880 m) stations to determine whether there were any significant differences by severity...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2007.06.008
更新日期：2007-12-05 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/s0031-9384(97)00150-9
更新日期：1997-07-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(92)90068-d
更新日期：1992-05-01 00:00:00
abstract：:In 1975, at the start of my junior year in college, I took a course on experimental methods in psychology from Dr. James C. Smith, when he was a Visiting Professor at Penn State University. That experience set me on the professional path of studying the neural bases of taste function and ingestion on which I remain to...
journal_title：Physiology & behavior
pub_type： 历史文章,杂志文章
doi：10.1016/j.physbeh.2015.04.026
更新日期：2015-12-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(89)90245-x
更新日期：1989-08-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.physbeh.2020.112831
更新日期：2020-05-15 00:00:00
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pub_type： 杂志文章
doi：10.1016/s0031-9384(01)00554-6
更新日期：2001-09-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/s0031-9384(01)00575-3
更新日期：2001-11-01 00:00:00
abstract：:Twenty-four-day old weanling male and female rats were either lesioned in the septal area, gonadectomized, lesioned and gonadectomized, or untreated. Tests for reactivity to electric shock were conducted at 26 and at 40 days of age. Neither males nor females showed any effect of the lesions are measured by flinch and ...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(77)90046-4
更新日期：1977-11-01 00:00:00
abstract：:Cocoa flavanols (CF) influence physiological processes in ways that suggest their consumption may improve aspects of neural function, and previous studies have found positive influences of CF on cognitive performance. In this preliminary study we investigated whether visual, as well as cognitive, function is influence...
journal_title：Physiology & behavior
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.physbeh.2011.02.013
更新日期：2011-06-01 00:00:00
abstract：:Cage stocking density can be manipulated by changing in cage size and group size in the cage. The effects of these two factors were investigated in three developmental stages in male rats: juvenile, post-pubertal, and adult. An open-field test was conducted to measure exploratory behavior which was influenced by level...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2005.01.008
更新日期：2005-03-16 00:00:00
abstract：:The palatability of a diet is an important determinant of energy intake. Due to a high palatability, a relatively high energy density, and a weak effect on satiation, the consumption of high-fat foods induces passive overfeeding. It is well known that a high-fat diet often leads to a loss of portion control of tasty f...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2005.12.014
更新日期：2006-08-30 00:00:00
abstract：:Jumping is a simple exercise determined by several biomechanical and physiological factors. Measures of vertical jump height are common and easy to administer tests of lower limb muscle power that are carried out with several types of equipment. This study aimed to validate and address the usefulness of the combinatio...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2020.113144
更新日期：2020-12-01 00:00:00
abstract：:The effects of chronic social stress on behavioral sensitization to cocaine were investigated in the Syrian hamster. Adolescent animals received either 15 mg/kg i.p. of cocaine or saline twice per day for 7 consecutive days. Two weeks following the last injection (young adulthood), they were given a challenge dose of ...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/s0031-9384(02)00727-8
更新日期：2002-08-01 00:00:00
abstract：:The medial preoptic area of the anterior hypothalamus (MPOA/AH) and the dorsolateral tegmentum (DLT) play an important role in the control of sexual behavior. Unilateral lesions of the MPOA/AH (medial preoptic area of the anterior hypothalamus) combined with unilateral lesions of the contralateral DLT result in defici...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/s0031-9384(98)00146-2
更新日期：1998-08-01 00:00:00
abstract：:This study aimed to investigate whether co-ingestion of carbohydrate and protein during exercise affect the post-exercise ad libitum food intake. Twelve healthy active male participants (mean±SD, age: 20±1; height: 176±6cm; weight: 63.6±5.3kg; VO2peak: 51.2±7.1ml/kg/min) completed three main experimental trials in a r...
journal_title：Physiology & behavior
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.physbeh.2017.07.030
更新日期：2017-10-01 00:00:00
abstract：:Cranially mounted differential preamplifiers allowed visual unit activity, EEGs and sustained potential shifts to be monitored from the tectum of freely moving toads (Bufo bufo). Alert behavior was elicited by a moving visual stimulus. Movement of the stimulus in the receptive field of a unit elicited its activity and...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(84)90264-6
更新日期：1984-03-01 00:00:00
