Abstract:
:The effects of loratadine, a peripherally acting histamine (H1) antagonist, and methysergide, a serotonin (5-HT) antagonist, were evaluated in seven normal-weight, male research volunteers, participating in a placebo-controlled, double-blind, 17-day residential study. Participants received oral loratadine (10 or 20 mg), methysergide (4 or 8 mg), or placebo at 1000 and 1700 hours daily. Active drug was administered on Days 4, 5, 7, 8, 11, 12, 15, and 16; placebo was administered on all other days. Drug and dose order were counterbalanced across participants. Food intake, performance, and subjective ratings were measured repeatedly throughout the day. Loratadine had no effect on food intake, performance, or subjective ratings. In contrast, total caloric intake significantly decreased from approximately 3500 kcal during placebo administration to 3065 kcal on the first but not the second day of methysergide administration. Consumption of carbohydrate (p < 0.055), protein, and fat decreased on the first day of methysergide administration. This decrease in food intake was due to a decrease in meal size; the number of meals consumed was not affected. The proportion of calories derived from carbohydrates significantly increased on the first day of methysergide administration. Methysergide also significantly impaired performance of a psychomotor task on the first day of high-dose administration and increased ratings of several subjective measures, including "Vomiting," "Stomach Pain," and "Miserable." These results suggest that the anorectic effect occurred as a result of the somatic and mood changes produced by methysergide. In addition, the inability of loratadine to affect food intake indicates that antagonism of central histamine receptors may be responsible for the increases in food intake produced by other antihistamines (e.g., diphenhydramine).
journal_name
Physiol Behavjournal_title
Physiology & behaviorauthors
Comer SD,Haney M,Ward AS,Fischman MW,Foltin RWdoi
10.1016/s0031-9384(98)00046-8subject
Has Abstractpub_date
1998-05-01 00:00:00pages
159-64issue
2eissn
0031-9384issn
1873-507Xpii
S0031-9384(98)00046-8journal_volume
64pub_type
临床试验,杂志文章abstract::Pigeons were allowed to feed for 1 h either 2 h after lights on (morning pulse) or 3 h before lights off (evening pulse). Body temperature was measured radiotelemetrically. Faecal excretion, as an index of rate of digestion, was measured using load cells. At 22 degrees C, faecal excretion peaked just after lights-on i...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/s0031-9384(03)00031-3
更新日期:2003-03-01 00:00:00
abstract::Human participants judged the pungency of various concentrations of carbon dioxide presented to one nostril, the other nostril, or both (dichorhinic stimulation). Perceived magnitude grew sharply with concentration over the range explored. The combinatorial rule of bilateral integration followed the Pythagorean theore...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(82)90025-7
更新日期:1982-08-01 00:00:00
abstract::The current study examined the effects of electrolytic median raphe lesions on the performance of several T-maze discrimination tasks. Raphe lesions were found to impair the reversal, but not the acquisition, of a learned position habit, but to be without effect on either the acquisition or reversal of simultaneous br...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(86)90223-4
更新日期:1986-01-01 00:00:00
abstract::Both subjective and objectively measured social status has been associated with multiple health outcomes, including weight status, but the mechanism for this relationship remains unclear. Experimental studies may help identify the causal mechanisms underlying low social standing as a pathway for obesity. Our objective...
journal_title:Physiology & behavior
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.physbeh.2016.04.024
更新日期:2016-08-01 00:00:00
abstract::We studied the effect of intrauterine food restriction (FR) on the immune function, endocrine status and attractiveness of scents of male rat-like hamsters, Cricetulus triton. Work was conducted on field-caught parents from the North China plain and their laboratory-born progeny. Restricted pregnant dams were fed 70% ...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2004.04.008
更新日期:2004-09-15 00:00:00
abstract::Environmental conditions promote weight gain in children and adults, with early nutritional states and the availability of energy condensed/high-fat palatable diets appearing to facilitate the development of obesity. Little is known about the extent to which prenatal and postnatal dietary manipulations alter the respo...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2010.07.018
更新日期:2010-11-02 00:00:00
abstract::Midbrain raphe lesions induced aggressive behavior which was characterized by defensive aggression rather than offensive aggression in nature. Furthermore, raphe-lesioned rats exhibited muricide. This muricide included not only mouse-killing but also mouse-eating behavior. Both dorsal and medial raphe lesioned (dm-R) ...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(77)90166-4
更新日期:1977-07-01 00:00:00
abstract::This study examined the behavioral responses of near-term rat fetuses to a range of chemosensory fluids that resemble constituents of milk or are present in the context of suckling immediately after birth. Milk and dimethyl disulfide (DMDS), a constituent of pup saliva that promotes postnatal nipple attachment, were e...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(92)90411-t
更新日期:1992-10-01 00:00:00
abstract::A novel model to evaluate erectile, ejaculatory, and sexual behavior patterns in conscious mouse is presented. Corpus spongiosum of the penis (CSP) pressure was recorded by using telemetry and was correlated with erectile activity (penile elongations, cups, flips) during reflex induction and spontaneous erections in f...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2007.04.016
更新日期:2007-08-15 00:00:00
abstract::Djungarian and Syrian hamsters were found to exhibit robust water intake following water deprivation, and in response to hyperosmotic and hypovolumetric challenges to body fluids following injections of hypertonic NaCl and polyethylene glycol, respectively. Water intake was not stimulated following peripheral injectio...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(88)90388-5
更新日期:1988-01-01 00:00:00
abstract::To cover their energy demands, prey animals are forced to search for food. However, during foraging they also expose themselves to the risk of becoming the prey of predators. Consequently, in order to increase their fitness foraging animals have to trade-off efficiency of foraging against the avoidance of predation ri...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2015.11.005
更新日期:2016-02-01 00:00:00
abstract::Physical restraint, like many other stressors, can block early pregnancy, but the underlying physiological mechanisms have not been established. Exogenous estrogens in minute doses will also block early pregnancy. In the present study, female rats were exposed to 5 h of restraint daily for the first 5 days after insem...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(92)90446-9
更新日期:1992-07-01 00:00:00
abstract::To test the hypothesis that testosterone (T) sexually differentiates gonadotropin secretion and sexual behavior by inducing synthesis of messenger RNA (mRNA), newborn female rats received intrahypothalamic infusions of saline or cordycepin, an adenosine analogue that preferentially inhibits synthesis of polyadenylated...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(87)90264-2
更新日期:1987-01-01 00:00:00
abstract::We previously reported that in male rats, 24 h of social housing with an associate male rat immediately following fear conditioning attenuated conditioned hyperthermia in response to an auditory conditioned stimulus. In this study, we investigated the time window and threshold of social housing where "social buffering...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2010.10.025
更新日期:2011-02-01 00:00:00
abstract::The present study describes a wheel turn/tail flick paradigm that was designed to simultaneously assess nociceptive thresholds of responses organized at spinal and supraspinal levels of the CNS in the rat. The paradigm involves training rats to perform an operant wheel turn response in order to escape current applied ...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(90)90028-3
更新日期:1990-05-01 00:00:00
abstract::A group of young adult females, who had or had not eaten breakfast, drank either a glucose drink or a placebo. Fasting was associated with poorer performance on the Brown-Petersen task, a test of memory. A glucose drink improved the memory of those who had fasted, although it did not influence those who had eaten brea...
journal_title:Physiology & behavior
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0031-9384(99)00040-2
更新日期:1999-08-01 00:00:00
abstract::Rats weighing 45-50 g were fed 3 diets for 8 wk: a balanced control diet (CD) consisting of 4% fat (polyunsaturated/saturated fatty acids [P/S] ratio 2.9/1) and two fat-rich diets: polyunsaturated (UD)--P/S 7.6/1 and saturated (SD) P/S 0.3/1. After 8 wk feeding on the respective diets, rats were subjected to swimming ...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(94)90342-5
更新日期:1994-11-01 00:00:00
abstract::In earlier work, we found that following lipopolysaccharide (LPS) injection at an ambient temperature (Ta) of 23 degrees C, old rats developed blunted fevers compared with those of young rats. However, the old rats did become febrile if placed in a thermally graded alleyway: they spent more time in the warm end of the...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/s0031-9384(03)00046-5
更新日期:2003-04-01 00:00:00
abstract::Crib-biting in the horse is frequently prevented in the short-term by horse-owners using physical means. Because it has been proposed that crib-biting may function to reduce stress, the effect of prevention of crib-biting and/or eating on the behaviour, heart rate, and plasma cortisol and beta-endorphin concentrations...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/s0031-9384(98)00070-5
更新日期:1998-08-01 00:00:00
abstract::The adult suprachiasmatic nuclei (SCN) express neural cell adhesion molecule (NCAM) that carries polysialic acid (PSA), a carbohydrate polymer which controls plastic cell-cell interactions in neural tissues. Expression of the three major isoforms of NCAM [180 (principal PSA carrier), 140, and 120 kDa) varies with deve...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/s0031-9384(01)00468-1
更新日期:2001-05-01 00:00:00
abstract::Dried bonito dashi is often used in Japanese cuisine with a number of documented positive health effects. Its major taste is thought to be umami, elicited by inosine 5'-monophosphate (IMP) and L-amino acids. Previously we found that lactic acid, a major component of dried bonito dashi, enhanced the contribution of man...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2018.11.016
更新日期:2019-02-01 00:00:00
abstract::Individual differences in open-field activity and emotionality (number of defecations and urinations), voluntary wheel running, voluntary and forced maximal sprint running speed on a photocell-timed racetrack, swimming endurance, and maximal oxygen consumption (VO2max) were studied in 35 random bred male ICR mice. Wit...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(92)90438-8
更新日期:1992-07-01 00:00:00
abstract::Due to previous work where we have demonstrated attenuated febrile responses post-lipopolysaccharide (LPS) in calorie restricted (CR) rodents we aimed to explore metabolic rate and behavioral thermoregulation in these CR animals post-LPS. Male Sprague-Dawley rats fed ad libitum (AL) or restricted to 50% (CR50%) of the...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2012.06.009
更新日期:2012-12-05 00:00:00
abstract::Sea bass, a fish species characterized by its dualistic feeding pattern, was investigated to study the synchronizing effect of light and food on the demand-feeding rhythm. Nocturnal and diurnal sea bass, both in groups and individually, were exposed to restricted-feeding (RF) and light-dark (LD) cycles of different pe...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(95)00116-z
更新日期:1995-10-01 00:00:00
abstract::The present study was designed to characterize and assess the reliability of acute mood responses to maximal exercise in women. All subjects (N = 22; age = 45 +/- 2.5 yr; BMI = 24.3 +/- 0.9 kg/m2) participated in two maximal walking tests spaced approximately one month apart. The abbreviated Profile of Mood States (PO...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(94)00195-b
更新日期:1995-01-01 00:00:00
abstract::There is still controversy surrounding the effectiveness of dietary interventions for autism spectrum disorder (ASD), namely the gluten-free/casein free diet and the ketogenic diet. Additionally, as studies mainly investigated their impact on ASD symptoms and behaviors, much remains unknown about their mechanisms of a...
journal_title:Physiology & behavior
pub_type: 杂志文章,评审
doi:10.1016/j.physbeh.2018.07.014
更新日期:2018-10-01 00:00:00
abstract::A simple device constructed from inexpensive components enables spike activity to be integrated and displayed in a convenient scale (spikes/sec) on a pen recorder. An input voltage threshold detection circuit is employed to eliminate any random baseline noise from being integrated. A pulse output is provided to drive ...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(75)90151-1
更新日期:1975-01-01 00:00:00
abstract::Oxidative damage is one of the hallmarks of the aging process. The current study evaluated effects of two proprietary antioxidant-based ingredients, rosemary extract and spearmint extract containing carnosic acid and rosmarinic acid, respectively, on learning and memory in the SAMP8 mouse model of accelerated aging. T...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2016.08.013
更新日期:2016-10-15 00:00:00
abstract::This study mainly explored the thermal comfort from the perspective of physiology. Three physiological parameters, including skin temperature (local and mean), electrocardiograph (ECG) and electroencephalogram (EEG), were investigated to see how they responded to the ambient temperature and how they were related to th...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2007.09.012
更新日期:2008-01-28 00:00:00
abstract::For this series of experiments, we wanted to investigate issues related to stress and learning. First, we wanted to determine if unpredictable stress might foster generalized fear responses more than predictable stress. Second, we wanted to evaluate how repeated stress might influence a rat's ability to learn what con...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2019.05.017
更新日期:2019-09-01 00:00:00