Behavioral analyses of taste function and ingestion in rodent models.

Abstract:

:In 1975, at the start of my junior year in college, I took a course on experimental methods in psychology from Dr. James C. Smith, when he was a Visiting Professor at Penn State University. That experience set me on the professional path of studying the neural bases of taste function and ingestion on which I remain to this day. Along the way, I did my graduate work at Florida State University under the tutelage of Jim, I did my postdoctoral training at the University of Pennsylvania under the supervision of Harvey Grill, and I also worked closely with Ralph Norgren, who was at the Penn State Medical College. This article briefly summarizes some of the lessons I learned from my mentors and highlights a few key research findings arising from my privilege of working with gifted students and postdocs. After close to 40 years of being a student of the gustatory system and ingestive behavior, it is still with the greatest conviction that I believe rigorous analysis of behavior is indispensable to any effort seeking to understand brain function.

journal_name

Physiol Behav

journal_title

Physiology & behavior

authors

Spector AC

doi

10.1016/j.physbeh.2015.04.026

subject

Has Abstract

pub_date

2015-12-01 00:00:00

pages

516-26

issue

Pt B

eissn

0031-9384

issn

1873-507X

pii

S0031-9384(15)00233-4

journal_volume

152

pub_type

历史文章,杂志文章
  • Event related potentials recorded from rats performing a reaction-time task.

    abstract::We recorded evoked potentials during performance of a reaction-time task, in which rats had to release a lever quickly in response to either a visual or an auditory stimulus for a food reward. We found two distinct peaks in their cortical evoked potentials. The first peak appeared at a fixed time after the stimulus, i...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(88)90145-x

    authors: Brenner E,Mirmiran M

    更新日期:1988-01-01 00:00:00

  • Influence of adrenalectomy on the odor detection performance of rats.

    abstract::The influence of adrenalectomy (ADX) on the odor detection performance of male Long-Evans rats was assessed using high-precision olfactometry and a go/no-go operant signal detection task. Nonparametric signal detection measures of sensitivity and responsivity, as well as measures of S+ response latency, the number of ...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(91)90362-r

    authors: Doty RL,Risser JM,Brosvic GM

    更新日期:1991-06-01 00:00:00

  • Restrained eaters show altered brain response to food odor.

    abstract::Do restrained and unrestrained eaters differ in their brain response to food odor? We addressed this question by examining restrained eaters' brain response to food (chocolate) and non-food (geraniol, floral) odors, both when odor was attended to and when ignored. Using olfactory event-related potentials (OERPs), we f...

    journal_title:Physiology & behavior

    pub_type: 临床试验,杂志文章

    doi:10.1016/j.physbeh.2005.10.008

    authors: Kemmotsu N,Murphy C

    更新日期:2006-02-28 00:00:00

  • Spatio-temporal integration in the substrate for self-stimulation of the prefrontal cortex.

    abstract::The number of stimulation pulses required to maintain a half maximal rate of self-stimulation of the prefrontal cortex (PFC) was determined for various currents. Over a restricted range, the effects of decreasing the stimulation frequency could be compensated for by increasing the current. This finding cannot easily b...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(85)90353-1

    authors: Schenk S,Prince C,Shizgal P

    更新日期:1985-08-01 00:00:00

  • Fatty acid responses in taste cells from obesity-prone and -resistant rats.

    abstract::One of the transduction mechanisms for the chemoreception of fat has been proposed to involve the inhibition of delayed rectifying potassium (DRK) channels by polyunsaturated free fatty acids (PUFAs). In the present study we have compared the responsiveness of fungiform taste receptor cells (TRCs) to fatty acids in ob...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2005.08.057

    authors: Gilbertson TA,Liu L,Kim I,Burks CA,Hansen DR

    更新日期:2005-12-15 00:00:00

  • Ratings of perceived recovery and exertion in elite youth soccer players: Interchangeability of 10-point and 100-point scales.

    abstract::The purpose of this study was to examine the interchangeability of a new perceived recovery status scale (PRS) of 100 points through a comparison to the original 10-point version. This study also aimed to test the interchangeability of CR100 scale (Borg's rate of perceived exertion scale) in comparison to the CR10. Tw...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2019.112641

    authors: Clemente FM,Rabbani A,Araújo JP

    更新日期:2019-10-15 00:00:00

  • Behavioral effects of LPS in adult, middle-aged and aged mice.

    abstract::Acute infections lead to alterations in behavior, collectively known as sickness behavior, which includes reduction in locomotion, food ingestion, sexual and social behavior, environmental exploration, and sleep profile. Although generally seen as undesired, sickness behavior represents a conserved strategy for animal...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2008.10.018

    authors: Kinoshita D,Cohn DW,Costa-Pinto FA,de Sá-Rocha LC

    更新日期:2009-02-16 00:00:00

  • Properties of smooth pursuit adaptation induced by theta motion.

    abstract::Current study attempted to determine whether repeated smooth pursuit trials using theta motion, in which the directions of retinal image-motion and object-motion are opposed, yield pursuit adaptation. Adaptation trials consisted of 350 step-ramp trials using theta motion, and pre- and post-trials using first-order mot...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2020.113245

    authors: Miyamoto T,Miura K,Kizuka T,Ono S

    更新日期:2021-02-01 00:00:00

  • Social stress does not alter the expression of sensitization to cocaine.

    abstract::The effects of chronic social stress on behavioral sensitization to cocaine were investigated in the Syrian hamster. Adolescent animals received either 15 mg/kg i.p. of cocaine or saline twice per day for 7 consecutive days. Two weeks following the last injection (young adulthood), they were given a challenge dose of ...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/s0031-9384(02)00727-8

    authors: Trzcińska M,Bergh J,DeLeon K,Stellar JR,Melloni RH Jr

    更新日期:2002-08-01 00:00:00

  • Baroreceptor involvement in classically conditioned heart rate responses of restrained rats.

    abstract::A group (N = 8) of restrained, baroreceptor denervated rats and a sham-operated-control group (n = 8) received discriminated classical conditioning consisting of 30 reinforced trials in which a CS+ was paired with an electric shock US and 30 non-reinforced trials in which a different CS (CS-) was presented alone. The ...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(84)90009-x

    authors: Hatton DC,Foutz SR,Fitzgerald RD

    更新日期:1984-07-01 00:00:00

  • Refeeding after acute food restriction: differential reduction in preference for ethanol and ethanol-paired flavors in selectively bred rats.

    abstract::Rats' voluntary ethanol intake varies with dispositional factors and energy status. The joint influences of these were of interest here. We previously reported that rats selectively bred for high voluntary saccharin intake (HiS) consume more ethanol and express more robust conditioning of preference for flavors paired...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2012.12.001

    authors: Dess NK,Chapman CD,Cousins LA,Monroe DC,Nguyen P

    更新日期:2013-01-17 00:00:00

  • Relation of autogrooming to sexual behavior in male rats.

    abstract::Grooming and penile reflexes were studied in male rats that were restrained in supine position with the penile sheath retracted or were free to copulate with sexually receptive females. In Experiment 1 there was a reliable concordance in supine males between the tendency to groom and the tendency to display penile ref...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(88)90219-3

    authors: Sachs BD,Clark JT,Molloy AG,Bitran D,Holmes GM

    更新日期:1988-01-01 00:00:00

  • Umami and appetite: effects of monosodium glutamate on hunger and food intake in human subjects.

    abstract::Subjects consumed soup (beef consomme) preloads of a fixed size containing different concentrations of monosodium L-glutamate (MSG). Effects on appetite following these preloads, and when no soup was consumed, were assessed in 3 studies. The soups supplemented with MSG were rated as more "pleasant," more "savoury" and...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(90)90230-2

    authors: Rogers PJ,Blundell JE

    更新日期:1990-12-01 00:00:00

  • Allo-parental care in Damaraland mole-rats is female biased and age dependent, though independent of testosterone levels.

    abstract::In Damaraland mole-rats (Fukomys damarensis), non-breeding subordinates contribute to the care of offspring born to the breeding pair in their group by carrying and retrieving young to the nest. In social mole-rats and some cooperative breeders, dominant females show unusually high testosterone levels and it has been ...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2018.03.021

    authors: Zöttl M,Vullioud P,Goddard K,Torrents-Ticó M,Gaynor D,Bennett NC,Clutton-Brock T

    更新日期:2018-09-01 00:00:00

  • Consumption of cocoa flavanols results in an acute improvement in visual and cognitive functions.

    abstract::Cocoa flavanols (CF) influence physiological processes in ways that suggest their consumption may improve aspects of neural function, and previous studies have found positive influences of CF on cognitive performance. In this preliminary study we investigated whether visual, as well as cognitive, function is influence...

    journal_title:Physiology & behavior

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.physbeh.2011.02.013

    authors: Field DT,Williams CM,Butler LT

    更新日期:2011-06-01 00:00:00

  • Concentration-dependent licking of sucrose and sodium chloride in rats with parabrachial gustatory lesions.

    abstract::The medial zone of parabrachial nuclei (PBN) serves as an obligatory synapse in the central gustatory system in rodents. Lesions in the PBN impair taste aversion learning and depletion-induced sodium appetite in rats, and also alter the ingestion of sapid stimuli. Interpretation of these lesion-induced behavioral defi...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(93)90205-t

    authors: Spector AC,Grill HJ,Norgren R

    更新日期:1993-02-01 00:00:00

  • The effect of active hypohydration on cognitive function: A systematic review and meta-analysis.

    abstract::Hypohydration is generally considered to have a negative effect on cognitive function, despite several studies reporting comparable findings between hydration states. Recommendations to avoid moderate dehydration (≥ 2% loss in body mass) are commonly made to athletes, on the provision that this deficit may impair opti...

    journal_title:Physiology & behavior

    pub_type: 杂志文章,meta分析

    doi:10.1016/j.physbeh.2019.03.008

    authors: Goodman SPJ,Moreland AT,Marino FE

    更新日期:2019-05-15 00:00:00

  • Evolutionary insights into the regulation of courtship behavior in male amphibians and reptiles.

    abstract::Comparative studies of species differences and similarities in the regulation of courtship behavior afford an understanding of evolutionary pressures and constraints shaping reproductive processes and the relative contributions of hormonal, genetic, and ecological factors. Here, we review species differences and simil...

    journal_title:Physiology & behavior

    pub_type: 杂志文章,评审

    doi:10.1016/j.physbeh.2004.08.021

    authors: Woolley SC,Sakata JT,Crews D

    更新日期:2004-11-15 00:00:00

  • Changes in the satiating effect of cholecystokinin over repeated trials.

    abstract::The study investigated the reasons for discrepant published results concerning a diminution of the satiating action of cholecystokinin (CCK) when it is administered over several trials. Throughout the experiment, rats were maintained on a schedule in which they were fasted for 5.5 h (except 5 ml of milk), and then giv...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2005.04.023

    authors: Duncan EA,Davita G,Woods SC

    更新日期:2005-07-21 00:00:00

  • Both increases and decreases in energy density lead to sustained changes in preschool children's energy intake over 5 days.

    abstract:BACKGROUND AND OBJECTIVE:To investigate preschool children's ability to self-regulate their energy intake, we assessed their response to increases or decreases in dietary energy density (ED) over 5 consecutive days, a period likely long enough for compensatory behavior. METHODS:Using a crossover design, over 3 periods...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2019.02.042

    authors: Smethers AD,Roe LS,Sanchez CE,Zuraikat FM,Keller KL,Rolls BJ

    更新日期:2019-05-15 00:00:00

  • Analysis of walking locomotion in adult female rats undernourished as sucklings.

    abstract::Suckling rats were undernourished from birth by underfeeding their mothers. They were refed from 3 weeks of age. Detailed analyses were made of the walking locomotion of previously undernourished and well-fed control female rats at 10 weeks, using electronic, computer, and TV techniques. Previously undernourished rats...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(92)90421-w

    authors: Clarke KA,Parker AJ,Smart JL

    更新日期:1992-10-01 00:00:00

  • Modulation of male mouse sociosexual and anxiety-like behaviors by vasopressin receptors.

    abstract::Although the involvement of two types of vasopressin (AVP) receptors, v1a and v1b, in neural regulation of social behavior is well documented in rodents, there is no report on combined actions of them in regulation of social behavior. In this study, we investigated behavioral differences between wild-type (WT) and v1a...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2018.09.016

    authors: Shimizu K,Nakamura K,Yokosuka M,Kondo Y

    更新日期:2018-12-01 00:00:00

  • Chronic nicotine and withdrawal effects on body weight and food and water consumption in female rats.

    abstract::Female rats were used to examine the effects of chronic nicotine administration and withdrawal on food and water consumption and body weight. Rats with chronic nicotine pellet implants consumed significantly less food and water than controls for the first five days and then gradually returned to control levels of cons...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(87)90370-2

    authors: Levin ED,Morgan MM,Galvez C,Ellison GD

    更新日期:1987-01-01 00:00:00

  • Heart rate response of the rat fetus and neonate to a chemosensory stimulus.

    abstract::Resting heart rate (HR) and HR responses of fetal and neonatal rats are described before and after intraoral infusion of isotonic saline or lemon solution. Stable measurements of resting HR were obtained for fetuses over the last three days of gestation (E19, E20, E21) and pups on the day of birth (P0) and four subseq...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(91)90496-b

    authors: Smotherman WP,Robinson SR,Ronca AE,Alberts JR,Hepper PG

    更新日期:1991-07-01 00:00:00

  • Fluoxetine-maintained obese humans: effect on food intake and body weight.

    abstract::The effects of fluoxetine on food intake, body weight, and mood of obese individuals was examined in a 16-week inpatient/outpatient study. Six male and eight female obese volunteers began the study (four male and five females completed all phases of the study). They lived in a residential laboratory during three one-w...

    journal_title:Physiology & behavior

    pub_type: 临床试验,杂志文章

    doi:10.1016/s0031-9384(99)00020-7

    authors: Ward AS,Comer SD,Haney M,Fischman MW,Foltin RW

    更新日期:1999-07-01 00:00:00

  • Schisantherin A recovers Aβ-induced neurodegeneration with cognitive decline in mice.

    abstract::Schisantherin A (STA) is a main bioactive lignan isolated from Schisandra chinensis (Turcz.) Baill., which has been widely used as a tonic in traditional Chinese medicine for many years. Lots of studies have reported that STA exhibited anti-inflammatory and antioxidant effects. This paper was designed to investigate t...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2014.04.046

    authors: Li X,Zhao X,Xu X,Mao X,Liu Z,Li H,Guo L,Bi K,Jia Y

    更新日期:2014-06-10 00:00:00

  • Stripes disrupt odour attractiveness to biting horseflies: battle between ammonia, CO₂, and colour pattern for dominance in the sensory systems of host-seeking tabanids.

    abstract::As with mosquitoes, female tabanid flies search for mammalian hosts by visual and olfactory cues, because they require a blood meal before being able to produce and lay eggs. Polarotactic tabanid flies find striped or spotted patterns with intensity and/or polarisation modulation visually less attractive than homogene...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2013.06.013

    authors: Blahó M,Egri A,Száz D,Kriska G,Akesson S,Horváth G

    更新日期:2013-07-02 00:00:00

  • Effects of aerobic training, resistance training, or both on brain-derived neurotrophic factor in adolescents with obesity: The hearty randomized controlled trial.

    abstract::Brain derived neurotrophic factor (BDNF) is a protein that plays a critical role in modulating cognition in animals and humans. Aerobic exercise often increases BDNF in adults, but effects of this exercise modality and others among adolescents remain uncertain. This study examined the effects of aerobic training, resi...

    journal_title:Physiology & behavior

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.physbeh.2018.04.026

    authors: Goldfield GS,Kenny GP,Prud'homme D,Holcik M,Alberga AS,Fahnestock M,Cameron JD,Doucette S,Hadjiyannakis S,Tulloch H,Tremblay MS,Walsh J,Guerin E,Gunnell KE,D'Angiulli A,Sigal RJ

    更新日期:2018-07-01 00:00:00

  • Gustatory changes associated with the menstrual cycle.

    abstract::We studied changes in the palatability and gustatory functions as they correlate with the menstrual cycle in 30 healthy females with regular menstrual cycles. The gustatory function was investigated by conducting electrogustometry and by the filter-paper disk method with taste solutions in the follicular and luteal ph...

    journal_title:Physiology & behavior

    pub_type: 临床试验,杂志文章

    doi:10.1016/s0031-9384(98)00307-2

    authors: Kuga M,Ikeda M,Suzuki K

    更新日期:1999-04-01 00:00:00

  • Genetic obestiy: estrogenic influences on the body weight and food intake of lean and obese adult Zucker (fa/fa) rats.

    abstract::The effects of chronic estrogen withdrawal and subsequent hormone replacement on the feeding and body weight of adult lean and genetically obese Zucker rats were investigated. Following confirmation of a delay in the vaginal canalization of the fatty rat, subgroups of each genotype received either ovariectomy or sham ...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(79)90130-6

    authors: Gale SK,Van Itallie TB

    更新日期:1979-07-01 00:00:00