Abstract:
:Brain derived neurotrophic factor (BDNF) is a protein that plays a critical role in modulating cognition in animals and humans. Aerobic exercise often increases BDNF in adults, but effects of this exercise modality and others among adolescents remain uncertain. This study examined the effects of aerobic training, resistance training, and combined training on resting serum BDNF levels in adolescents with overweight and obesity. After a 4-week pre-randomization treatment, 304 post-pubertal, adolescents with overweight or obesity (70% females) aged 14-18 years were randomized to one of four groups for 22 weeks: aerobic training (N = 75), resistance training (N = 78), combined aerobic and resistance training (N = 75), or non-exercising control (N = 76). All participants received dietary counseling targeting a daily energy deficit of 250 kcal. The exercise prescription was 4 times per week, progressing to 45 min/session for the aerobic and resistance groups and 90 min/session for the combined group. Resting serum BDNF levels were measured at baseline and 6-months. Results showed that in both intention-to-treat (ITT) and per protocol (≥70% adherence to prescribed sessions) analyses, there were no significant within- or between-group changes in BDNF. Findings indicate that aerobic training, resistance training or their combination did change serum BDNF levels in adolescents with overweight and obesity. TRIAL REGISTRATION:ClinicalTrials.Gov NCT00195858 http://clinicaltrials.gov/show/NCT00195858, September 12, 2005 (Funded by the Canadian Institutes of Health Research).
journal_name
Physiol Behavjournal_title
Physiology & behaviorauthors
Goldfield GS,Kenny GP,Prud'homme D,Holcik M,Alberga AS,Fahnestock M,Cameron JD,Doucette S,Hadjiyannakis S,Tulloch H,Tremblay MS,Walsh J,Guerin E,Gunnell KE,D'Angiulli A,Sigal RJdoi
10.1016/j.physbeh.2018.04.026subject
Has Abstractpub_date
2018-07-01 00:00:00pages
138-145eissn
0031-9384issn
1873-507Xpii
S0031-9384(18)30207-5journal_volume
191pub_type
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journal_title:Physiology & behavior
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journal_title:Physiology & behavior
pub_type: 临床试验,杂志文章,随机对照试验
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