Abstract:
:Leptin is a protein that is produced primarily in fat tissue and is thought to be a lipostatic feedback signal for the regulation of body fat stores. The purpose of this study was to determine the behavioral specificity of i.c.v.-administered mouse leptin in rats and to assess the effects on meal patterns. Using a modified two-bottle paradigm we examined the putative aversive response to i.c.v. doses of 1, 5, 7, 10, and 30 microg of mouse leptin. Artificial CSF and intraperitoneal lithium chloride served as negative and positive controls, respectively. Saccharin consumption in all leptin treatments was not significantly different from the negative control. Following a recovery period, rats from the same group were used to assess the effects of a 30-microg i.c.v. dose on cumulative food intake and meal patterns using a computer-based system for acquisition of feeding data. Leptin (i.c.v.) significantly increased intermeal interval and decreased meal size. We, therefore, conclude that mouse leptin, at doses up to 30 microg i.c.v., is not aversive in the rat, and that leptin has a multiphasic effect on meal patterns.
journal_name
Physiol Behavjournal_title
Physiology & behaviorauthors
Hulsey MG,Lu H,Wang T,Martin RJ,Baile CAdoi
10.1016/s0031-9384(98)00180-2subject
Has Abstractpub_date
1998-12-01 00:00:00pages
445-55issue
3eissn
0031-9384issn
1873-507Xpii
S0031-9384(98)00180-2journal_volume
65pub_type
杂志文章abstract::Specific areas of feline central gray (CG) modulate affective aggression elicited by hypothalamic stimulation and produce analgesia, possibly mediated by enkephalins. Despite correlations between opiates and aggressive behavior suggested previously, their relationship has not been clearly demonstrated. The goal of thi...
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journal_title:Physiology & behavior
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journal_title:Physiology & behavior
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journal_title:Physiology & behavior
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更新日期:1996-06-01 00:00:00
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journal_title:Physiology & behavior
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journal_title:Physiology & behavior
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1990-01-01 00:00:00
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journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(89)90228-x
更新日期:1989-05-01 00:00:00
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journal_title:Physiology & behavior
pub_type: 杂志文章
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