Dietary interventions for autism spectrum disorder: New perspectives from the gut-brain axis.

Abstract:

:There is still controversy surrounding the effectiveness of dietary interventions for autism spectrum disorder (ASD), namely the gluten-free/casein free diet and the ketogenic diet. Additionally, as studies mainly investigated their impact on ASD symptoms and behaviors, much remains unknown about their mechanisms of action and physiological effects. Given the recent surge of global interest in the gut-brain axis and its involvement in ASD, we underline the importance of understanding the physiological effects of such restrictive diets that remove certain nutritional items from one's diet. Some evidence has emerged with findings of the gut-microbial, inflammatory, and neuronal effects of these diets. We propose probiotics as a potential alternative that can serve similar biological purposes as these elimination diets and outline different physiological routes whereby probiotics can lead to improvements for individuals with ASD. We hope that future research can delineate the complete physiological effects of these diets. Such knowledge can guide the creation of more informed interventions, which conserve the components resulting in positive behavioral change while being less restrictive and devoid of the harmful effects of limiting certain nutrients.

journal_name

Physiol Behav

journal_title

Physiology & behavior

authors

Doenyas C

doi

10.1016/j.physbeh.2018.07.014

subject

Has Abstract

pub_date

2018-10-01 00:00:00

pages

577-582

eissn

0031-9384

issn

1873-507X

pii

S0031-9384(18)30508-0

journal_volume

194

pub_type

杂志文章,评审
  • Differences in intestinal microbial metabolites in laying hens with high and low levels of repetitive feather-pecking behavior.

    abstract::Feather pecking in laying hens is a serious behavioral problem and is often associated with feather eating. There is some evidence that ingested feathers affect gut function. The aim of the present study was to explore whether differences in intestinal microbial metabolites in laying hens with high and low levels of r...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2012.12.017

    authors: Meyer B,Zentek J,Harlander-Matauschek A

    更新日期:2013-02-17 00:00:00

  • Parent-child mealtime interactions associated with toddlers' refusals of novel and familiar foods.

    abstract::Parents' feeding practices have been associated with children's dietary quality and food acceptance, but previous studies have largely relied exclusively on questionnaires to assess both parent and child behavior. The current study explored the relationships between parents' reported and observed feeding practices and...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2017.03.001

    authors: Fries LR,Martin N,van der Horst K

    更新日期:2017-07-01 00:00:00

  • Viral depletion of calcitonin receptors in the area postrema: A proof-of-concept study.

    abstract::The area postrema (AP), located in the caudal hindbrain, is one of the primary binding sites for the endocrine satiation hormone amylin. Amylin is co-secreted with insulin from pancreatic ß-cells and binds to heterodimeric receptors that consist of a calcitonin core receptor (CTR) paired with receptor-activity modifyi...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2020.112992

    authors: Coester B,Foll CL,Lutz TA

    更新日期:2020-09-01 00:00:00

  • Effect of the serotonin agonist buspirone on behaviour and hypothalamic-pituitary-adrenal axis in confident and fearful mink.

    abstract::Behavioural and hypothalamic-pituitary-adrenal (HPA) axis responses were investigated in farm mink (Mustela vison) selected for either confident or fearful behaviour for nine generations. Two groups of 2-year-old confident (n=12) and fearful (n=12) female mink were given the serotonin (5-HT) 1A receptor agonist buspir...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/s0031-9384(02)00964-2

    authors: Malmkvist J,Hansen SW,Damgaard BM

    更新日期:2003-02-01 00:00:00

  • The neural code for taste in the brain stem: response profiles.

    abstract::In the study of the neural code for taste, two theories have dominated the literature: the across neuron pattern (ANP), and the labeled line theories. Both of these theories are based on the observations that taste cells are multisensitive across a variety of different taste stimuli. Given a fixed array of taste stimu...

    journal_title:Physiology & behavior

    pub_type: 信件,评审

    doi:10.1016/s0031-9384(00)00191-8

    authors: Di Lorenzo PM

    更新日期:2000-04-01 00:00:00

  • Beta-endorphin-like immunoreactivity levels in the hypothalamus, the periaqueductal grey and the pituitary of the DBA mouse: determination by ELISA and relationship to nociception.

    abstract::The present paper describes the development and application of an enzyme-linked immunosorbent assay (ELISA) for the assessment of beta-endorphin-like immunoreactivity (beta-ELIR) level in the hypothalamus, the periaqueductal grey (PAG) and the pituitary of DBA/2 mice that were subjected to mild social stress (aggressi...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(89)90315-6

    authors: Külling P,Siegfried B,Frischknecht HR,Messiha FS,Pasi A

    更新日期:1989-07-01 00:00:00

  • Effect of viscosity on appetite and gastro-intestinal hormones.

    abstract::In previous studies we showed that higher viscosity resulted in lower ad libitum intake and that eating rate is an important factor. In this study we aimed to explore the effect of viscosity on the gastro-intestinal hormones ghrelin, CCK-8 and GLP-1. Thirty-two subjects (22+/-2 y, BMI 21.9+/-2.2 kg/m(2)) participated ...

    journal_title:Physiology & behavior

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.physbeh.2009.02.001

    authors: Zijlstra N,Mars M,de Wijk RA,Westerterp-Plantenga MS,Holst JJ,de Graaf C

    更新日期:2009-04-20 00:00:00

  • A new method for aversive Pavlovian conditioning of heart rate in rhesus monkeys.

    abstract::Aversive Pavlovian conditioning is an important tool used to investigate neurobiological mechanisms underlying the acquisition and expression of fear. Most studies have used nonprimate species employing electrical shock as the unconditioned stimulus (US). Although important advances have been made in understanding the...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(96)00145-x

    authors: Kalin NH,Shelton SE,Davidson RJ,Lynn DE

    更新日期:1996-10-01 00:00:00

  • Effects of cocaine-induced seizures during pregnancy in the rabbit.

    abstract::The effects of chronic administration of cocaine to pregnant rabbits on maternal seizures and on pregnancy outcome were studied. Cocaine (2, 3 or 4 mg/kg/injection) or saline was administered, I.V., twice daily, from gestation Day 8 (G8) to G29. There were no significant differences in maternal weight gain or pregnanc...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/s0031-9384(97)00170-4

    authors: Murphy EH,Chon J,Darvish-Sefat F,Diven K,Schumann M,Shumsky JS

    更新日期:1997-09-01 00:00:00

  • Ingestion in the satiated rat: role of alpha and beta receptors in mediating effects of hypothalamic adrenergic stimulation.

    abstract::Anterior perifornical hypothalamic injection of l-norepinephrine in satiated rats elicits a brief, vigorous drinking response followed within a minute or two by a vigorous feeding response. These adrenergically elicited responses, which bear striking similarities to a rat's naturally motivated ingestive behaviors, wer...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(75)90066-9

    authors: Leibowitz SF

    更新日期:1975-06-01 00:00:00

  • Gonadal ERα/β, AR and TRPV1 gene expression: modulation by pain and morphine treatment in male and female rats.

    abstract::The results of several studies strongly indicate a bidirectional relationship among gonadal hormones and pain. While gonadal hormones play a key role in pain modulation, they have been found to be affected by pain therapies in different experimental and clinical conditions. However, the effects of pain and pain therap...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2012.12.014

    authors: Vodo S,Arcelli D,Fiorenzani P,Meriggiola MC,Butkevich I,Di Canio C,Mikhailenko V,Aloisi AM

    更新日期:2013-02-17 00:00:00

  • Impaired social motivation and increased aggression in rats subchronically exposed to phencyclidine.

    abstract::Phencyclidine (PCP) treatment induces social withdrawal in the rat model of schizophrenia but little is known about the qualitative adequacy of behaviors displayed during interactions. Affiliative, avoidance, and aggressive behaviors were examined in rats 20 h after the 1st, the 8th, and the 15th injection of 10 mg/kg...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2008.11.002

    authors: Audet MC,Goulet S,Doré FY

    更新日期:2009-03-02 00:00:00

  • Neonatal capsaicin treatment attenuates sensory-induced analgesia and nociception.

    abstract::Neonatal capsaicin treatment (50 mg/kg SC in two-day-old rats) increased thermal pain thresholds in both sexes when measured at different ages, decreased the responsiveness of adult females to specific noxious stimulation, and differentially decreased the magnitude of vaginocervical stimulation (VS)-produced analgesia...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(91)90412-h

    authors: Masters DB,Komisaruk BR

    更新日期:1991-11-01 00:00:00

  • Monoamine metabolism and its responses to food deprivation in the brain of Zucker rats.

    abstract::Monoamines and their metabolites levels were simultaneously measured by high-performance liquid chromatography in brain regions of lean and fatty Zucker rats when fed ad lib and deprived of food for 72 hr to evaluate each monoamine metabolism. Metabolite/monoamine ratios were shown for brevity to represent its metabol...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(88)90311-3

    authors: Tsujii S,Nakai Y,Fukata J,Nakaishi S,Takahashi H,Usui T,Imura H,Ikeda H,Matsuo T

    更新日期:1988-01-01 00:00:00

  • Differential heart rate variability and physiological responses associated with accumulated short- and long-term stress in rodents.

    abstract::In this study, we tested the hypothesis that chronic stress has cumulative effects over time on heart rate variability (HRV) and physiological responses in a rodent model of chronic mild stress. Rats were exposed to either short-term (2weeks) or long-term (4weeks) stress, followed by a 1-week recovery period. Controls...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2016.12.036

    authors: Park SE,Park D,Song KI,Seong JK,Chung S,Youn I

    更新日期:2017-03-15 00:00:00

  • Thirst and fluid intake following graded hypohydration levels in humans.

    abstract::The relationship among changes in thirst sensations, blood variables, and differential fluid intake in hypohydrated humans was examined. Seven subjects were hypohydrated by 0%, 3%, 5%, and 7% of their body weight on four separate trials which were systematically randomized between subjects. Hypohydration levels were a...

    journal_title:Physiology & behavior

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/0031-9384(87)90212-5

    authors: Engell DB,Maller O,Sawka MN,Francesconi RN,Drolet L,Young AJ

    更新日期:1987-01-01 00:00:00

  • Oil enriched diets and behavioral parameters in rats' recovery from early undernutrition.

    abstract::The effect of oil enriched diets on sexual and exploratory behavior has been studied in male rats undernourished in utero and during lactation. At 20 days of age, for a period of 4 months, these animals were fed with 3 different diets: standard diet, standard diet enriched with 7% soybean oil, and standard diet enrich...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/s0031-9384(97)00150-9

    authors: Fernandez S,Gonzalez C,Patterson AM

    更新日期:1997-07-01 00:00:00

  • Flavour-specific anticipatory hunger reinforced by either carbohydrate or protein.

    abstract::Recent evidence indicates that rats can learn to avoid aversive consequences of several hours of food deprivation by eating more of food having orosensory characteristics that predict a protracted fast. Two new studies tested if macronutrient composition of a flavoured meal before the reinforcing fast influences this ...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2006.02.007

    authors: Thibault L,Booth DA

    更新日期:2006-06-15 00:00:00

  • Effect of viscosity on learned satiation.

    abstract::A higher viscosity of a food leads to a longer orosensory stimulation. This may facilitate the learned association between sensory signals and metabolic consequences. In the current study we investigated the effect of viscosity on learned satiation. In two intervention groups a low viscosity (LV) yogurt (n=24) and a h...

    journal_title:Physiology & behavior

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.physbeh.2009.04.018

    authors: Mars M,Hogenkamp PS,Gosses AM,Stafleu A,De Graaf C

    更新日期:2009-08-04 00:00:00

  • Emotional reactivity in mice, a case of nongenetic heredity?

    abstract::Nongenetic heredity cases have been described in man, as well as in animals, and relationships between parents and offspring seem to play an important role in this transmission. In mice, mothering type could be nongenetically heritable by a latent learning close to mechanism. As mothering style clearly influences emot...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/s0031-9384(01)00566-2

    authors: Calatayud F,Belzung C

    更新日期:2001-10-01 00:00:00

  • The role of the midbrain reticular formation in the expression of two opposing nigral denervation syndromes.

    abstract::The present study investigated the role of the midbrain reticular formation (MRF) in the expression of opposing locomotor asymmetries elicited from the medial and lateral substantia nigra pars compacta (SNC). It was found that unilateral MRF lesions produced ipsiversive circling that was potentiated by amphetamine. La...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(85)90406-8

    authors: Vaccarino FJ,Franklin KB,Prupas D

    更新日期:1985-11-01 00:00:00

  • Does touch matter? The impact of stroking versus non-stroking maternal touch on cardio-respiratory processes in mothers and infants.

    abstract::The beneficial effects of touch in development were already observed in different types of skin-to-skin care. In the current study, we aimed at studying potential underlying mechanisms of these effects in terms of parasympatho-inhibitory regulation. We examined the specific impact of affective maternal stroking versus...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2019.04.024

    authors: Van Puyvelde M,Gorissen AS,Pattyn N,McGlone F

    更新日期:2019-08-01 00:00:00

  • Auditory-evoked brainstem responses in the torpid deermouse.

    abstract::This study examined auditory-evoked brainstem responses (ABR) in the deermouse (Peromyscus maniculatus) during torpor and arousal. The ABR of the euthermic deermouse consisted of five waves occurring in a time frame of 10 ms. During torpor, ABR wave I could be elicited at slow, but not fast stimulation rates indicatin...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(95)02019-5

    authors: Katbamna B,Thodi C,Senturia JB

    更新日期:1996-01-01 00:00:00

  • Fluoxetine-maintained obese humans: effect on food intake and body weight.

    abstract::The effects of fluoxetine on food intake, body weight, and mood of obese individuals was examined in a 16-week inpatient/outpatient study. Six male and eight female obese volunteers began the study (four male and five females completed all phases of the study). They lived in a residential laboratory during three one-w...

    journal_title:Physiology & behavior

    pub_type: 临床试验,杂志文章

    doi:10.1016/s0031-9384(99)00020-7

    authors: Ward AS,Comer SD,Haney M,Fischman MW,Foltin RW

    更新日期:1999-07-01 00:00:00

  • Salt consumption increases blood pressure and abolishes the light/dark rhythm in angiotensin AT1a receptor deficient mice.

    abstract::Experiments were performed to study the role of angiotensin (Ang) AT1a receptors in dietary sodium-induced changes in blood pressure (BP). We measured light/dark rhythms in BP, heart rate (HR) and drinking behavior in Ang AT1a deficient (AT1a -/-) and wild type (AT1a +/+) mice with arterial telemetric catheters. Mice ...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2006.03.008

    authors: Chen Y,Oroszi TL,Morris M

    更新日期:2006-06-15 00:00:00

  • Acute and chronic administration of immunomodulators induces anorexia in Zucker rats.

    abstract::To investigate the possible involvement of leptin signaling in lipopolysaccharide (LPS) anorexia, we compared the anorectic effect of LPS in genetically obese (fa/fa) Zucker rats and in their lean (Fa/?) counterparts. The effects of interleukin-1beta (IL-1beta) and muramyl dipeptide (MDP) were also tested. LPS [100 mi...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2004.11.003

    authors: Lugarini F,Hrupka BJ,Schwartz GJ,Plata-Salaman CR,Langhans W

    更新日期:2005-01-31 00:00:00

  • Affect asymmetry and comfort food consumption.

    abstract::It is proposed that the emotional triggers of comfort food consumption can reliably be predicted by factors tied to affect asymmetry whereby negative affects dominate one's experience, decision making and behaviors in some instances while positive emotions prevail in others. Specifically, we relate three of these fact...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2005.08.023

    authors: Dubé L,LeBel JL,Lu J

    更新日期:2005-11-15 00:00:00

  • Level searching: a new assay of sexual motivation in the male rat.

    abstract::Mendelson and Gorzalka recently described a bilevel chamber for the evaluation of rodent sexual behavior. In initial studies it was observed that during 5 min adaptation periods prior to the introduction of a sexually receptive female rat, male rats with prior sexual experience in these chambers would move from level ...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(89)90136-4

    authors: Mendelson SD,Pfaus JG

    更新日期:1989-02-01 00:00:00

  • Neuroendocrine-associated behavioral patterns in the male Asian elephant (Elephas maximus).

    abstract::Steroid-responsive behaviors have been reported in various species; however, the reports thus far on the male Asian elephant (bull) during musth are few in number and most have been conducted on single captive animals for short time periods. The purpose of this investigation was to perform a longitudinal study on ster...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/s0031-9384(96)00563-x

    authors: Dickerman RD,Zachariah NY,Fouraker M,McConathy WJ

    更新日期:1997-05-01 00:00:00

  • Peripheral atropinization does not change meal size controlled by prepyloric mechanisms.

    abstract::To investigate the role of gastric contractility in the prepyloric control of meal size, we administered atropine methyl nitrate (3 mg/kg,ip) or saline prior to 30-min tests on 3 separate days in which 0.8 M sucrose was ingested by rats after 1 h of food deprivation. Ingested 0.8 M sucrose accumulated in the stomach a...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(95)02132-9

    authors: Rauhofer EA,Greenberg D,Smith GP

    更新日期:1996-02-01 00:00:00