Abstract:
:To investigate the possible involvement of leptin signaling in lipopolysaccharide (LPS) anorexia, we compared the anorectic effect of LPS in genetically obese (fa/fa) Zucker rats and in their lean (Fa/?) counterparts. The effects of interleukin-1beta (IL-1beta) and muramyl dipeptide (MDP) were also tested. LPS [100 microg/kg body weight (BW)], IL-1beta (2 microg/kg BW) and MDP (2.2 mg/kg BW) injected intraperitoneally (i.p.) at lights out reduced food intake similarly in obese and lean rats. LPS injection at 500 or 1000 microg/kg BW (i.p.) also reduced food intake and BW similarly in obese and lean rats, but obese regained BW faster than lean rats. LPS (2.45 microg or 9.8 microg/h/rat) administered chronically with i.p. implanted osmotic pumps reduced food intake similarly on experimental day 1, regardless of the genotype. After day 3, the lean rats' anorectic response and recovery were dose-dependent, whereas the anorectic response in obese rats was minimally affected by dose (significant dose effect only on day 3). Again, obese rats regained lost BW faster than lean rats. These results do not support a role for leptin as the sole mediator of anorexia induced by bacterial products (LPS and MDP) and IL-1beta.
journal_name
Physiol Behavjournal_title
Physiology & behaviorauthors
Lugarini F,Hrupka BJ,Schwartz GJ,Plata-Salaman CR,Langhans Wdoi
10.1016/j.physbeh.2004.11.003subject
Has Abstractpub_date
2005-01-31 00:00:00pages
165-73issue
1eissn
0031-9384issn
1873-507Xpii
S0031-9384(04)00474-3journal_volume
84pub_type
杂志文章abstract::Impaired nonshivering thermogenesis and lowered rectal temperatures (Tre) are hallmarks that appear early in the postnatal ontogeny of the genetically obese (ob/ob) mouse. Adult obese mice compensate behaviorally for these impairments and do not defend their low Tres. We predicted that, because young mice primarily re...
journal_title:Physiology & behavior
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journal_title:Physiology & behavior
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journal_title:Physiology & behavior
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journal_title:Physiology & behavior
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abstract::For a better understanding of the encoding of odor quality in the olfactory system, it is critical to determine how electrophysiological responses to odorants are reflected in the behavioral responses to these odorants. In this article, we use a simple behavioral paradigm to show that the behavioral responses to simil...
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journal_title:Physiology & behavior
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journal_title:Physiology & behavior
pub_type: 杂志文章
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更新日期:1984-04-01 00:00:00
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abstract::The green anole, Anolis carolinensis, is the most thoroughly studied North American lizard species, yet little is known about the circadian system of this species. Studies in several lizard species, including Anolis, support the hypothesis that the pineal organ is the site of a major circadian pacemaker that controls ...
journal_title:Physiology & behavior
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doi:10.1016/0031-9384(92)90292-a
更新日期:1992-08-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/0031-9384(93)90018-b
更新日期:1993-01-01 00:00:00
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doi:10.1016/j.physbeh.2016.06.016
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更新日期:1995-09-01 00:00:00
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更新日期:1982-04-01 00:00:00
abstract::Evaluation of the participation of different substantia nigra sites in the sensitization of resistant (R) animals to audiogenic seizures (AS), was performed after series of small (5 mC; n = 28), medium (10 mC; n = 57) and large (15 mC; 3 points of 5 mC each, n = 19) unilateral electrolytic lesions of the substantia ni...
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journal_title:Physiology & behavior
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更新日期:2017-10-15 00:00:00
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