Abstract：
:Experiments were performed to study the role of angiotensin (Ang) AT1a receptors in dietary sodium-induced changes in blood pressure (BP). We measured light/dark rhythms in BP, heart rate (HR) and drinking behavior in Ang AT1a deficient (AT1a -/-) and wild type (AT1a +/+) mice with arterial telemetric catheters. Mice were given ad libitum access to a high salt diet (8% NaCl, HSD for 8 days) and tap water. The major finding was that the Ang AT1a -/- mice showed enhanced sodium sensitivity. This was seen by a greater percentage increase in BP (+21% vs. +12%) and an earlier onset of BP change (increase on day 5 vs. day 8) in AT1a -/- vs. AT1a +/+. The normal light/dark BP rhythm was abolished in AT1a -/- after 5 days of HSD. HSD produced an increase in water intake (drinking activity and volume consumed) in both groups with no difference in the percentage increase or the light/dark drinking rhythm. HSD produced no changes in plasma osmolality, hematocrit or body weight in either group. Evidence shows that a deficiency of Ang AT1a receptors results in an enhancement in sodium sensitivity along with a disruption of the normal light/dark BP rhythm. The data combined with previous findings suggests that activation of other components of the renin angiotensin system and/or sympathetic pathways may be responsible for the cardiovascular changes in AT1a deficient mice.
journal_name
Physiol Behavjournal_title
Physiology & behaviorauthors
Chen Y,Oroszi TL,Morris Mdoi
10.1016/j.physbeh.2006.03.008subject
Has Abstractpub_date
2006-06-15 00:00:00pages
95-100issue
1-2eissn
0031-9384issn
1873-507Xpii
S0031-9384(06)00101-6journal_volume
88pub_type
杂志文章abstract：:The discovery that pleasant touch is coded by C-tactile fibers has generated considerable research interest and increased understanding of the skin as a channel for social information via cutaneous senses. However, no study has differentiated between the pleasant response to visual and tactile non-human stimulations. ...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2017.12.022
更新日期：2018-03-01 00:00:00
abstract：:The cephalic phase of digestion (CPD) has been extensively investigated in terms of digestion and metabolism. Nevertheless, microcirculatory changes required to prepare peripheral tissues in order to dispose nutrients have never been assessed. In this study, microvascular function has been evaluated to determine its b...
journal_title：Physiology & behavior
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.physbeh.2011.12.004
更新日期：2012-02-28 00:00:00
abstract：:We examined the time course and sex differences of the glucocorticoid response to forced, moderate-intensity treadmill exercise in outbred laboratory house mice. Mice (n = 64 total) were divided into eight groups, each of four males and four females, which were run on a motorized treadmill at 1.0 km/h for either 0, 2,...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/s0031-9384(97)00441-1
更新日期：1998-01-01 00:00:00
abstract：:The sensation of thirst plays an important role in the consumption of water or other fluids to rehydrate the body in order to keep bodily functions working properly. An increase in saliva secretion, wetting the mouth by ingestion of liquids, and cooling and sour components in products can alleviate this sensation alre...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2017.08.007
更新日期：2017-10-15 00:00:00
abstract：:The effect of single and chronic methamphetamine (MAP) administration on ischemia-induced hyperactivity was investigated and the mechanism of ischemia-induced hyperactivity was discussed. Ischemia-induced hyperactivity was recognized 3 h after ischemia. However, ischemia-induced hyperactivity at 1 day after ischemia w...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/s0031-9384(01)00549-2
更新日期：2001-09-01 00:00:00
abstract：:This study was designed to determine the differences between young and elderly people on the perceived intensity and pleasantness of sucrose in foods, in relation to their food intake. First, a group of 35 young subjects (mean age: 22 +/- 2 years) and 29 elderly subjects (mean age: 79 +/- 6 years) judged the intensity...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/s0031-9384(96)00306-x
更新日期：1996-12-01 00:00:00
abstract：:Sex hormones have been reported to dynamically modulate the expression of implicit motives, a concept that has previously been thought to be relatively stable over time. This study investigates to what extent the need for affiliation, power, and achievement, as well as the form of enactment of these needs as measured ...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2013.09.016
更新日期：2014-01-17 00:00:00
abstract：:The effects of amphetamine (5-20 mg/kg) were studied 60 min after injection in mice aged 2, 3, 4 and 6 weeks postpartum. Exploratory behavior as indicated by the "head poke" test was depressed at all ages, but appeared to be relatively uncomplicated by other effects at the 5 mg/kg dose. At 4 and 6 weeks control female...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(86)90261-1
更新日期：1986-01-01 00:00:00
abstract：:Olfactory bulbectomy (OBX) is a well known screening model for depression. Panax quinquefolium (PQ) is known for its therapeutic potential against several psychiatric disorders. Nitric oxide (NO), an intercellular messenger has been suggested to play a crucial role in the pathogenesis of depression. The present study ...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2014.02.037
更新日期：2014-04-22 00:00:00
abstract：:Several studies have shown that growth hormone (GH)-deficient/resistant animals have a prolonged lifespan compared with their normal siblings. Studies in our laboratory have suggested that both Ames dwarf and GH receptor/GH binding protein knockout (GH-R-KO) mice do not experience age-induced cognitive aging at the sa...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2003.10.018
更新日期：2004-02-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/s0031-9384(01)00598-4
更新日期：2001-10-01 00:00:00
abstract：:Environmental conditions promote weight gain in children and adults, with early nutritional states and the availability of energy condensed/high-fat palatable diets appearing to facilitate the development of obesity. Little is known about the extent to which prenatal and postnatal dietary manipulations alter the respo...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2010.07.018
更新日期：2010-11-02 00:00:00
abstract：:Rats adrenalectomized (ADX) on day 11 of life display enhanced brain growth due, at least in part, to a stimulation of cell proliferation and myelinogenesis. The present study investigated some functional consequences of this treatment. Rats were ADX or sham-operated (SHAM) on postnatal day 11 and then tested in adult...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(88)90040-6
更新日期：1988-01-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2016.12.040
更新日期：2017-03-15 00:00:00
abstract：:The aim of this work was to demonstrate the occurrence of oxidative stress during exhaustive exercise and to determine the antioxidant response. Eight voluntary male subjects participated in this study. The exercise was a cycling mountain stage (171 km) and the cyclists took a mean+/-S.E.M. time of 270+/-12 min to com...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2004.07.034
更新日期：2005-01-31 00:00:00
abstract：:Beta,beta'-iminodipropionitrile (IDPN)-induced muscle weakness in rats is a model for motorneuropathy diseases. The effects of oral administration of branched-chain amino acids on the progression of muscle weakness and muscle atrophy induced by the administration of IDPN in the drinking water, were investigated in thi...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/s0031-9384(97)00154-6
更新日期：1997-09-01 00:00:00
abstract：:The coordination and regulation of electrical signals across excitable cells is a complex, dynamic phenomenon requiring, in part, the interaction of ion channels with cellular constituents. The intracellular loops or domains of many ion channel subunits have been shown to specifically bind other cellular components th...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/s0031-9384(02)00912-5
更新日期：2002-12-01 00:00:00
abstract：:Rats were weaned early (Day 15), normally (Day 21) or late (Day 27). When they reached 200 g (+/- 10) they were placed into the activity-stress paradigm. Half the rats in each weaning group were housed in activity-wheel cages and fed only 1 hr each day. The remaining rats served as food-yoked home cage controls and we...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(85)90012-5
更新日期：1985-06-01 00:00:00
abstract：:In Damaraland mole-rats (Fukomys damarensis), non-breeding subordinates contribute to the care of offspring born to the breeding pair in their group by carrying and retrieving young to the nest. In social mole-rats and some cooperative breeders, dominant females show unusually high testosterone levels and it has been ...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2018.03.021
更新日期：2018-09-01 00:00:00
abstract：BACKGROUND:'Low-carb' diets have been suggested to be effective in body weight (BW) management. However, these diets are relatively high in protein as well. OBJECTIVE:To unravel whether body-weight loss and weight-maintenance depends on the high-protein or the 'low-carb' component of the diet. DESIGN:Body-weight (BW)...
journal_title：Physiology & behavior
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.physbeh.2012.08.004
更新日期：2012-10-10 00:00:00
abstract：:Flavor-nutrient learning occurs when the post-ingestive consequences of a food are associated with its flavor. As a signal of the food's energy density, flavor-nutrient associations have the potential to contribute to the regulation of meal size. While all calorie sources (fat, carbohydrate, protein, ethanol) can supp...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2009.03.007
更新日期：2009-06-22 00:00:00
abstract：:Rats exhibit a sensitive period from the time of birth until postnatal day 10 during which they develop preferences for odors even if those odors are paired with a moderately aversive stimulus. It is still unknown whether pre-exposure to an odor produces alterations on intake responses of basic tastants, and on other ...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2014.12.041
更新日期：2015-09-01 00:00:00
abstract：:Sea bass, a fish species characterized by its dualistic feeding pattern, was investigated to study the synchronizing effect of light and food on the demand-feeding rhythm. Nocturnal and diurnal sea bass, both in groups and individually, were exposed to restricted-feeding (RF) and light-dark (LD) cycles of different pe...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(95)00116-z
更新日期：1995-10-01 00:00:00
abstract：BACKGROUND:Sex may influence the relationship between HPA axis functioning and obesity. This has been suggested to be due to sex-specific differences in body composition, body fat distribution and psychological variables. Age and the use of oral contraceptives may also influence the relationship between HPA axis functi...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2012.02.016
更新日期：2012-05-15 00:00:00
abstract：:Mesolimbic dopamine plays a critical role in food-related reward processing and learning. The literature focuses primarily on the nucleus accumbens as the key dopaminergic target in which enhanced dopamine signaling is associated with reward. Here, we demonstrate a novel neurobiological mechanism by which dopamine tra...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2014.02.026
更新日期：2014-09-01 00:00:00
abstract：:Ten Hooded Lister rats were divided from weaning into two groups of five. One group was fed exclusively on a liquid diet in the home cage (Complan-fed subjects), the other group was given normal laboratory chow (Chow-fed subjects). At approximately 60 days of age both groups were reduced to 80% of their ad lib body-we...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(84)90062-3
更新日期：1984-01-01 00:00:00
abstract：:We have investigated the effects of peripherally administered pyruvate and lactate on the intake of high fat (HF) and low fat (LF) diets by a strain of rat either sensitive (Osborne-Mendel, OM) or resistant (SSB/Pl) to high fat-induced obesity. Both pyruvate and lactate inhibited the intake of HF and LF diets by OM ra...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(95)02109-4
更新日期：1996-03-01 00:00:00
abstract：:Pharmacogenetically selected apomorphine-susceptible (APO-SUS) and apomorphine-unsusceptible (APO-UNSUS) rats were trained in a discrimination learning paradigm. After the initial discrimination task was solved, reinforcement contingencies were reversed. No differences between APO-SUS and APO-UNSUS animals were found ...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(92)90278-a
更新日期：1992-08-01 00:00:00
abstract：:The present study describes a wheel turn/tail flick paradigm that was designed to simultaneously assess nociceptive thresholds of responses organized at spinal and supraspinal levels of the CNS in the rat. The paradigm involves training rats to perform an operant wheel turn response in order to escape current applied ...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(90)90028-3
更新日期：1990-05-01 00:00:00
abstract：:In an observational study with a blind observer, rhesus monkeys deficient in omega-3 (omega-3 or n-3) fatty acids initiated more bouts of stereotyped behavior in their home cages than monkeys fed a matched control diet abundant in omega-3 fatty acids. Locomotion bouts were also more frequent in deficient monkeys, but ...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(94)90128-7
更新日期：1994-02-01 00:00:00
